دورية أكاديمية
A Novel Porcine Circovirus Distantly Related to Known Circoviruses Is Associated with Porcine Dermatitis and Nephropathy Syndrome and Reproductive Failure.
| العنوان: | A Novel Porcine Circovirus Distantly Related to Known Circoviruses Is Associated with Porcine Dermatitis and Nephropathy Syndrome and Reproductive Failure. |
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| المؤلفون: | Palinski R; Department of Diagnostic Medicine and Pathobiology, Kansas State University, Manhattan, Kansas, USA., Piñeyro P; College of Veterinary Medicine, Iowa State University, Ames, Iowa, USA., Shang P; Department of Diagnostic Medicine and Pathobiology, Kansas State University, Manhattan, Kansas, USA., Yuan F; Department of Diagnostic Medicine and Pathobiology, Kansas State University, Manhattan, Kansas, USA., Guo R; Department of Diagnostic Medicine and Pathobiology, Kansas State University, Manhattan, Kansas, USA., Fang Y; Department of Diagnostic Medicine and Pathobiology, Kansas State University, Manhattan, Kansas, USA., Byers E; Smithfield Hog Production, Warsaw, North Carolina, USA., Hause BM; Department of Diagnostic Medicine and Pathobiology, Kansas State University, Manhattan, Kansas, USA hausebm@gmail.com.; Kansas State Veterinary Diagnostic Laboratory, Kansas State University, Manhattan, Kansas, USA. |
| المصدر: | Journal of virology [J Virol] 2016 Dec 16; Vol. 91 (1). Date of Electronic Publication: 2016 Dec 16 (Print Publication: 2017). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0113724 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1098-5514 (Electronic) Linking ISSN: 0022538X NLM ISO Abbreviation: J Virol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Washington Dc : American Society For Microbiology Original Publication: Baltimore, American Society for Microbiology. |
| مواضيع طبية MeSH: | Genome, Viral* , Phylogeny*, Abortion, Spontaneous/*epidemiology , Circovirus/*genetics , Dermatitis/*epidemiology , Porcine Postweaning Multisystemic Wasting Syndrome/*epidemiology , Swine Diseases/*epidemiology, Abortion, Spontaneous/mortality ; Abortion, Spontaneous/pathology ; Abortion, Spontaneous/virology ; Acute Disease ; Animals ; Antigens, Viral/genetics ; Antigens, Viral/immunology ; Canada/epidemiology ; Capsid/chemistry ; Capsid/immunology ; Capsid Proteins/genetics ; Capsid Proteins/immunology ; Circovirus/classification ; Circovirus/immunology ; Circovirus/isolation & purification ; Dermatitis/mortality ; Dermatitis/pathology ; Dermatitis/virology ; Female ; Fetus ; Immunologic Surveillance ; Kidney/pathology ; Kidney/virology ; Lung/pathology ; Lung/virology ; Lymph Nodes/pathology ; Lymph Nodes/virology ; North Carolina/epidemiology ; Porcine Postweaning Multisystemic Wasting Syndrome/mortality ; Porcine Postweaning Multisystemic Wasting Syndrome/pathology ; Porcine Postweaning Multisystemic Wasting Syndrome/virology ; RNA-Dependent RNA Polymerase/genetics ; RNA-Dependent RNA Polymerase/immunology ; Skin/pathology ; Skin/virology ; Survival Analysis ; Swine ; Swine Diseases/mortality ; Swine Diseases/pathology ; Swine Diseases/virology |
| مستخلص: | Porcine circovirus-associated disease (PCVAD) is clinically manifested by postweaning multisystemic wasting syndrome (PMWS), respiratory and enteric disease, reproductive failure, and porcine dermatitis and nephropathy syndrome (PDNS). Porcine circovirus 2 (PCV2) is an essential component of PCVAD, although an etiologic role in PDNS is not well established. Here, a novel circovirus, designated porcine circovirus 3 (PCV3), was identified in sows that died acutely with PDNS-like clinical signs. The capsid and replicase proteins of PCV3 are only 37% and 55% identical to PCV2 and bat circoviruses, respectively. Aborted fetuses from sows with PDNS contained high levels of PCV3 (7.57 × 10 7 genome copies/ml), and no other viruses were detected by PCR and metagenomic sequencing. Immunohistochemistry (IHC) analysis of sow tissue samples identified PCV3 antigen in skin, kidney, lung, and lymph node samples localized in typical PDNS lesions, including necrotizing vasculitis, glomerulonephritis, granulomatous lymphadenitis, and bronchointerstitial pneumonia. Further study of archived PDNS tissue samples that were negative for PCV2 by IHC analysis identified 45 of 48 that were PCV3 positive by quantitative PCR (qPCR), with 60% of a subset also testing positive for PCV3 by IHC analysis. Analysis by qPCR of 271 porcine respiratory disease diagnostic submission samples identified 34 PCV3-positive cases (12.5%), and enzyme-linked immunosorbent assay detection of anti-PCV3 capsid antibodies in serum samples found that 46 (55%) of 83 samples tested were positive. These results suggest that PCV3 commonly circulates within U.S. swine and may play an etiologic role in reproductive failure and PDNS. Because of the high economic impact of PCV2, this novel circovirus warrants further studies to elucidate its significance and role in PCVAD. Importance: While porcine circovirus 2 (PCV2) was first identified in sporadic cases of postweaning multisystemic wasting syndrome in Canada in the early 1990s, an epidemic of severe systemic disease due to PCV2 spread worldwide in the ensuing decade. Despite being effectively controlled by commercial vaccines, PCV2 remains one of the most economically significant viruses of swine. Here, a novel porcine circovirus (PCV3) that is distantly related to known circoviruses was identified in sows with porcine dermatitis and nephropathy syndrome (PDNS) and reproductive failure. PCV2, which has previously been associated with these clinical presentations, was not identified. High levels of PCV3 nucleic acid were observed in aborted fetuses by quantitative PCR, and PCV3 antigen was localized in histologic lesions typical of PDNS in sows by immunohistochemistry (IHC) analysis. PCV3 was also identified in archival PDNS diagnostic samples that previously tested negative for PCV2 by IHC analysis. The emergence of PCV3 warrants further investigation. (Copyright © 2016 American Society for Microbiology.) |
| References: | Virology. 2014 Nov;468-470:303-10. (PMID: 25217712) Arch Virol. 1998;143(9):1723-44. (PMID: 9787657) Virology. 2003 Jan 5;305(1):168-80. (PMID: 12504550) Arch Virol. 2007;152(5):1035-44. (PMID: 17219018) J Vet Diagn Invest. 2002 Nov;14(6):449-56. (PMID: 12423025) J Gen Virol. 2015 Oct;96(10):2994-8. (PMID: 26219947) Vet Pathol. 2009 Jul;46(4):707-16. (PMID: 19276045) Vet Microbiol. 2009 Nov 18;139(3-4):347-50. (PMID: 19570625) J Virol. 2012 Nov;86(22):12469. (PMID: 23087125) Acta Pathol Microbiol Immunol Scand Suppl. 1985;287:1-47. (PMID: 3000134) J Gen Virol. 2015 Jul;96(Pt 7):1830-41. (PMID: 25711965) Nucleic Acids Res. 1992 Jul 11;20(13):3279-85. (PMID: 1630899) Virus Res. 2009 Oct;145(1):151-6. (PMID: 19540280) PLoS One. 2015 Mar 19;10(3):e0121998. (PMID: 25789939) Vet Pathol. 1998 Jul;35(4):303-7. (PMID: 9684976) Vet Microbiol. 2015 Nov 18;180(3-4):186-95. (PMID: 26390821) Vet Rec. 1993 Feb 20;132(8):199. (PMID: 8451806) Vet Microbiol. 2004 Feb 4;98(2):175-83. (PMID: 14741131) J Virol Methods. 2014 Jun;201:68-72. (PMID: 24589514) Vet Microbiol. 2004 Feb 4;98(2):137-49. (PMID: 14741126) Proc Natl Acad Sci U S A. 2005 Sep 6;102(36):12891-6. (PMID: 16118271) Vet Microbiol. 2010 Jul 29;144(1-2):203-9. (PMID: 20097019) J Vet Med Sci. 2000 Jun;62(6):627-33. (PMID: 10907690) Vet Microbiol. 2004 Nov 30;104(1-2):113-7. (PMID: 15530745) Vet Rec. 1998 May 2;142(18):483-6. (PMID: 9612914) Arch Virol. 2001;146(4):835-42. (PMID: 11402869) PLoS One. 2014 Aug 22;9(8):e105909. (PMID: 25147946) Clin Diagn Lab Immunol. 2005 Jan;12(1):180-6. (PMID: 15643004) Vaccine. 2009 Feb 11;27(7):1002-7. (PMID: 19100807) J Gen Virol. 2015 Apr;96(Pt 4):915-20. (PMID: 25535324) J Gen Virol. 2005 Mar;86(Pt 3):631-5. (PMID: 15722523) Vet Microbiol. 2004 Apr 19;99(3-4):203-14. (PMID: 15066723) Vet Rec. 1998 Apr 25;142(17):467-8. (PMID: 9602519) Can Vet J. 2007 Mar;48(3):267-8. (PMID: 17436902) Anim Health Res Rev. 2010 Dec;11(2):217-34. (PMID: 21087576) J Gen Virol. 2016 Sep;97(9):2316-22. (PMID: 27324162) J Vet Diagn Invest. 2007 Jul;19(4):368-75. (PMID: 17609345) Virus Genes. 2014 Aug;49(1):1-10. (PMID: 25011695) J Vet Intern Med. 2009 Nov-Dec;23(6):1151-63. (PMID: 19780932) Vet Q. 2002 Sep;24(3):109-24. (PMID: 12400999) J Gen Virol. 2016 Feb;97(2):281-6. (PMID: 26581410) J Comp Pathol. 2000 Jan;122(1):9-24. (PMID: 10627387) Am J Vet Res. 2008 Dec;69(12):1615-22. (PMID: 19046009) J Gen Virol. 2004 Feb;85(Pt 2):293-304. (PMID: 14769887) Res Vet Sci. 2012 Dec;93(3):1231-40. (PMID: 22884005) J Gen Virol. 2011 Apr;92(Pt 4):768-72. (PMID: 21177928) J Comp Pathol. 1999 Jan;120(1):59-78. (PMID: 10098016) Virology. 2001 Aug 1;286(2):354-62. (PMID: 11485403) Can Vet J. 2007 Aug;48(8):811-9. (PMID: 17824323) Vet Rec. 1997 Dec 6;141(23):600-1. (PMID: 9429277) Emerg Infect Dis. 2013 Apr;19(4):534-41. (PMID: 23628223) Virology. 2003 May 25;310(1):41-9. (PMID: 12788629) J Biotechnol. 2016 Feb 20;220:78-85. (PMID: 26795354) Arch Virol. 2000;145(11):2421-9. (PMID: 11205128) Virology. 2001 Jan 20;279(2):392-400. (PMID: 11162795) J Vet Diagn Invest. 2000 Mar;12(2):151-3. (PMID: 10730945) Anim Health Res Rev. 2011 Jun;12(1):47-65. (PMID: 21676340) Vet Pathol. 1998 Mar;35(2):108-16. (PMID: 9539364) Virology. 2001 Jun 20;285(1):91-9. (PMID: 11414809) J Virol. 2010 Feb;84(4):1674-82. (PMID: 20007276) Can Vet J. 1998 Jan;39(1):44-51. (PMID: 9442952) Virology. 2007 Jan 20;357(2):175-85. (PMID: 16963096) J Comp Pathol. 1999 Jul;121(1):1-11. (PMID: 10373289) J Gen Virol. 2001 Nov;82(Pt 11):2805-9. (PMID: 11602793) Res Vet Sci. 2004 Dec;77(3):265-8. (PMID: 15276779) Virus Res. 2012 Mar;164(1-2):33-42. (PMID: 22005075) Vet Rec. 2001 Oct 6;149(14):412-7. (PMID: 11678213) Arch Virol. 2012 Jun;157(6):1173-6. (PMID: 22426897) Vet Rec. 2000 Jul 22;147(4):115. (PMID: 10955884) Vet Microbiol. 2011 Dec 15;153(3-4):229-39. (PMID: 21684696) Virus Res. 2012 Mar;164(1-2):10-9. (PMID: 22056845) Vet Rec. 1993 Jan 9;132(2):47. (PMID: 8442343) Vaccine. 2008 Feb 20;26(8):1063-71. (PMID: 18237827) PLoS One. 2012;7(7):e41463. (PMID: 22829951) Vet J. 2003 Nov;166(3):251-6. (PMID: 14550736) J Vet Diagn Invest. 1998 Jan;10(1):3-10. (PMID: 9526853) |
| فهرسة مساهمة: | Keywords: abortion; porcine circovirus; porcine dermatitis and nephropathy syndrome |
| المشرفين على المادة: | 0 (Antigens, Viral) 0 (Capsid Proteins) EC 2.7.7.48 (RNA-Dependent RNA Polymerase) |
| تواريخ الأحداث: | Date Created: 20161101 Date Completed: 20170515 Latest Revision: 20201209 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC5165205 |
| DOI: | 10.1128/JVI.01879-16 |
| PMID: | 27795441 |
| قاعدة البيانات: | MEDLINE |
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