دورية أكاديمية
أعرض في EDS

CXCL12 protects pancreatic β-cells from oxidative stress by a Nrf2-induced increase in catalase expression and activity.

التفاصيل البيبلوغرافية
العنوان: CXCL12 protects pancreatic β-cells from oxidative stress by a Nrf2-induced increase in catalase expression and activity.
المؤلفون: Dinić S; Department of Molecular Biology, Institute for Biological Research, University of Belgrade., Grdović N, Uskoković A, Đorđević M, Mihailović M, Jovanović JA, Poznanović G, Vidaković M
المصدر: Proceedings of the Japan Academy. Series B, Physical and biological sciences [Proc Jpn Acad Ser B Phys Biol Sci] 2016; Vol. 92 (9), pp. 436-454.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Japan Academy Country of Publication: Japan NLM ID: 9318162 Publication Model: Print Cited Medium: Internet ISSN: 1349-2896 (Electronic) Linking ISSN: 03862208 NLM ISO Abbreviation: Proc Jpn Acad Ser B Phys Biol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Ueno Park, Tokyo : Japan Academy,
مواضيع طبية MeSH: Catalase/*metabolism , Chemokine CXCL12/*pharmacology , Cytoprotection/*drug effects , Insulin-Secreting Cells/*cytology , Insulin-Secreting Cells/*enzymology , NF-E2-Related Factor 2/*metabolism , Oxidative Stress/*drug effects, Animals ; Antioxidants/metabolism ; Base Sequence ; Cell Line ; Cell Line, Tumor ; Humans ; Hydrogen Peroxide/toxicity ; Insulin-Secreting Cells/drug effects ; Male ; Models, Biological ; Phosphorylation/drug effects ; Promoter Regions, Genetic/genetics ; Protein Binding ; Rats, Wistar ; Transcription Factors/metabolism
مستخلص: Due to intrinsically low levels of antioxidant enzyme expression and activity, insulin producing pancreatic β-cells are particularly susceptible to free radical attack. In diabetes mellitus, which is accompanied by high levels of oxidative stress, this feature of β-cells significantly contributes to their damage and dysfunction. In light of the documented pro-survival effect of chemokine C-X-C Ligand 12 (CXCL12) on pancreatic β-cells, we examined its potential role in antioxidant protection. We report that CXCL12 overexpression enhanced the resistance of rat insulinoma (Rin-5F) and primary pancreatic islet cells to hydrogen peroxide (H 2 O 2 ). CXCL12 lowered the levels of DNA damage and lipid peroxidation and preserved insulin expression. This effect was mediated through an increase in catalase (CAT) activity. By activating downstream p38, Akt and ERK kinases, CXCL12 facilitated Nrf2 nuclear translocation and enhanced its binding to the CAT gene promoter, inducing constitutive CAT expression and activity that was essential for protecting β-cells from H 2 O 2 .
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المشرفين على المادة: 0 (Antioxidants)
0 (CXCL12 protein, human)
0 (Chemokine CXCL12)
0 (NF-E2-Related Factor 2)
0 (Nfe2l2 protein, rat)
0 (Transcription Factors)
BBX060AN9V (Hydrogen Peroxide)
EC 1.11.1.6 (Catalase)
تواريخ الأحداث: Date Created: 20161115 Date Completed: 20170327 Latest Revision: 20181113
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC5328787
DOI: 10.2183/pjab.92.436
PMID: 27840391
قاعدة البيانات: MEDLINE
الوصف
تدمد:1349-2896
DOI:10.2183/pjab.92.436