دورية أكاديمية
Effect of infusion of monoclonal antibodies to tumour necrosis factor-receptor super family 25 on graft rejection in allo-immune mice receiving autologous marrow transplantation.
| العنوان: | Effect of infusion of monoclonal antibodies to tumour necrosis factor-receptor super family 25 on graft rejection in allo-immune mice receiving autologous marrow transplantation. |
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| المؤلفون: | Gorczynski RM; Transplant Research Division, University Health Network and Toronto General Hospital, Toronto, ON, Canada.; Department of Immunology and Surgery, University of Toronto, Toronto, ON, Canada., Sadozai H; Transplant Research Division, University Health Network and Toronto General Hospital, Toronto, ON, Canada., Zhu F; Transplant Research Division, University Health Network and Toronto General Hospital, Toronto, ON, Canada., Khatri I; Transplant Research Division, University Health Network and Toronto General Hospital, Toronto, ON, Canada. |
| المصدر: | Immunology [Immunology] 2017 Apr; Vol. 150 (4), pp. 418-431. Date of Electronic Publication: 2016 Dec 22. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 0374672 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2567 (Electronic) Linking ISSN: 00192805 NLM ISO Abbreviation: Immunology Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford : Blackwell Scientific Publications |
| مواضيع طبية MeSH: | Bone Marrow Transplantation*, Antibodies, Monoclonal/*therapeutic use , Graft Rejection/*prevention & control , Immunotherapy/*methods , T-Lymphocytes, Regulatory/*immunology, Allografts/immunology ; Animals ; Cells, Cultured ; Graft Rejection/immunology ; Graft Survival ; Humans ; Immune Tolerance ; Isoantibodies/blood ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Receptors, Tumor Necrosis Factor, Member 25/immunology ; Transplantation, Homologous |
| مستخلص: | Significant barriers to transplantation exist for individuals who are pre-sensitized to donor antigen and have high titres of donor-reactive antibody. We report the effect of autologous bone marrow transplantation (BMTx) after myeloablation in pre-sensitized mice along with the use of monoclonal antibodies (mAbs) to tumour necrosis factor-receptor super family 25 (TNFRSF25), expressed on regulatory T (Treg) cells. C57BL/6 mice, which had been sensitized earlier with BALB/c skin allografts, received secondary BALB/c grafts after the primary grafts had been rejected. Subsequently, recipient mice underwent myeloablation with cyclophosphamide and busulphan and were injected with T-cell-depleted bone marrow from CD45.1 congenic donors (BMTx). Recipient mice underwent immunosuppressive treatment with rapamycin. A subgroup of mice was also treated with mAbs to TNFRSF25. Control mice were pre-sensitized mice that received cyclophosphamide and busulphan followed by rapamycin. BMTx-treated mice had significantly prolonged skin graft survival versus control mice. These mice also showed attenuated donor-specific mixed lymphocyte co-culture responses relative to controls, increased splenic Treg cells and markedly diminished serum anti-donor IgG. Infusion of anti-TNFRSF25 mAbs further augmented graft survival and increased graft-infiltrating Treg cells. These mAbs also expanded murine and human Treg cells in vitro with the capacity to attenuate mixed lymphocyte co-cultures using fresh peripheral blood mononuclear cells. Overall, this study delineates the roles of autologous BMTx and anti-TNFRSF25 mAbs in expanding Treg cells and attenuating alloimmune responses in pre-sensitized mice. (© 2016 John Wiley & Sons Ltd.) |
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| معلومات مُعتمدة: | Canada CIHR |
| فهرسة مساهمة: | Keywords: bone marrow transplantation; donor-reactive antibodies; myeloablation; regulatory T cells; tumour necrosis factor-receptor super family 25 |
| المشرفين على المادة: | 0 (Antibodies, Monoclonal) 0 (Isoantibodies) 0 (Receptors, Tumor Necrosis Factor, Member 25) 0 (Tnfrsf25 protein, mouse) |
| تواريخ الأحداث: | Date Created: 20161119 Date Completed: 20170531 Latest Revision: 20181113 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC5343351 |
| DOI: | 10.1111/imm.12693 |
| PMID: | 27859243 |
| قاعدة البيانات: | MEDLINE |
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