دورية أكاديمية
Sex differences in plaque characteristics by intravascular imaging in patients with coronary artery disease.
| العنوان: | Sex differences in plaque characteristics by intravascular imaging in patients with coronary artery disease. |
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| المؤلفون: | Ten Haaf ME; Department of Cardiology, VU University Medical Center Amsterdam, Amsterdam, the Netherlands., Rijndertse M, Cheng JM, de Boer SP, Garcia-Garcia HM, van Geuns RM, Regar E, Lenzen MJ, Appelman Y, Boersma E |
| المصدر: | EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology [EuroIntervention] 2017 Jun 20; Vol. 13 (3), pp. 320-328. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Société Europa édition Country of Publication: France NLM ID: 101251040 Publication Model: Print Cited Medium: Internet ISSN: 1969-6213 (Electronic) Linking ISSN: 1774024X NLM ISO Abbreviation: EuroIntervention Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Toulouse : Société Europa édition, c2005- |
| مواضيع طبية MeSH: | Sex Characteristics*, Coronary Artery Disease/*diagnostic imaging , Plaque, Atherosclerotic/*diagnostic imaging, Acute Coronary Syndrome/diagnostic imaging ; Aged ; Coronary Angiography/methods ; Coronary Artery Disease/etiology ; Female ; Humans ; Male ; Middle Aged ; Plaque, Atherosclerotic/complications ; Risk Factors ; Spectroscopy, Near-Infrared/methods ; Ultrasonography, Interventional/methods |
| مستخلص: | Aims: We aimed to study sex differences in coronary plaque burden and plaque composition in patients with coronary artery disease (CAD). Methods and Results: Virtual histology intravascular ultrasound (VH-IVUS) and near-infrared spectroscopy (NIRS) imaging of a non-culprit coronary artery was performed in 178 (23.5%) women and 581 (76.5%) men who underwent invasive management of stable angina pectoris (SAP) or acute coronary syndrome (ACS). Women were older and had a worse cardiovascular risk profile than men, but less extended angiographic coronary disease. Irrespective of the presenting diagnosis, women had lower VH-IVUS-derived plaque burden than men (38.1% vs. 40.5% in SAP, and 35.9% vs. 38.8% in ACS). Standardised (mean 211 vs. 263 mm3 in SAP, and 199 vs. 245 mm3 in ACS) total plaque volume was lower in women. Volumes of fibrous tissue, fibro-fatty tissue, necrotic core and dense calcium were also lower in women. NIRS-derived lipid core burden index (LCBI) was lower in women, in particular in SAP (mean LCBI in the worst 4 mm 220 vs. 240). The observed differences remained significant after adjustment for clinical characteristics. Conclusions: Women had more favourable plaque characteristics than men, despite their worse risk profile. Long-term follow-up studies are required to evaluate the clinical consequences. |
| تواريخ الأحداث: | Date Created: 20161122 Date Completed: 20180329 Latest Revision: 20180329 |
| رمز التحديث: | 20240628 |
| DOI: | 10.4244/EIJ-D-16-00361 |
| PMID: | 27867141 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1969-6213 |
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| DOI: | 10.4244/EIJ-D-16-00361 |