دورية أكاديمية
أعرض في EDS

Predictors of polycyclic aromatic hydrocarbon exposure and internal dose in inner city Baltimore children.

التفاصيل البيبلوغرافية
العنوان: Predictors of polycyclic aromatic hydrocarbon exposure and internal dose in inner city Baltimore children.
المؤلفون: Peters KO; Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA., Williams AL; Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA., Abubaker S; Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA., Curtin-Brosnan J; Department of Pediatrics, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA., McCormack MC; Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.; Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA., Peng R; Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA., Breysse PN; Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA., Matsui EC; Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.; Department of Pediatrics, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA., Hansel NN; Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.; Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA., Diette GB; Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.; Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA., Strickland PT; Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
المصدر: Journal of exposure science & environmental epidemiology [J Expo Sci Environ Epidemiol] 2017 May; Vol. 27 (3), pp. 290-298. Date of Electronic Publication: 2016 Dec 14.
نوع المنشور: Comparative Study; Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101262796 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-064X (Electronic) Linking ISSN: 15590631 NLM ISO Abbreviation: J Expo Sci Environ Epidemiol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York, NY : Nature Pub. Group, c2006-
مواضيع طبية MeSH: Air Pollutants/*adverse effects , Air Pollutants/*urine , Air Pollution/*adverse effects , Glucuronates/*urine , Polycyclic Aromatic Hydrocarbons/*adverse effects , Pyrenes/*urine, Black or African American/statistics & numerical data ; Air Pollution/analysis ; Air Pollution, Indoor/analysis ; Asthma ; Baltimore ; Child ; Child, Preschool ; Cities ; Cohort Studies ; Creatinine/urine ; Environmental Monitoring ; Female ; Humans ; Linear Models ; Male ; Nicotine/analysis ; Particulate Matter ; Polycyclic Aromatic Hydrocarbons/urine ; Seasons ; Sex Distribution ; Surveys and Questionnaires
مستخلص: Polycyclic aromatic hydrocarbons (PAHs), the by-products of incomplete combustion of organic materials, are commonly found on particulate matter (PM) and have been associated with the development of asthma and asthma exacerbation in urban populations. We examined time spent in the home and outdoors as predictors of exposures to airborne PAHs and measured urinary 1-hydroxypyrene-glucuronide (1-OHPG) as internal dose of PAHs in 118 children aged 5-12 years from Baltimore, MD. During weeklong periods (Saturday-Saturday) in each of four seasons: daily activities were assessed using questionnaires, indoor air nicotine and PM concentrations were monitored, and urine specimens were collected on Tuesday (day 3) and Saturday (day 7) for measurement of 1-OHPG. Time spent in non-smoking homes was associated with significantly decreased 1-OHPG concentration in urine (β=-0.045, 95% CI (-0.076, -0.013)), and secondhand smoke (SHS) exposures modified these associations, with higher urinary 1-OHPG concentrations in children spending time in smoking homes than non-smoking homes (P-value for interaction=0.012). Time spent outdoors was associated with increased urinary 1-OHPG concentrations (β=0.097, 95% CI (0.037, 0.157)) in boys only. Our results suggest that SHS and ambient (outdoor) air pollution contribute to internal dose of PAHs in inner city children.
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معلومات مُعتمدة: P01 ES018176 United States ES NIEHS NIH HHS; P50 ES015903 United States ES NIEHS NIH HHS; P50 ES018176 United States ES NIEHS NIH HHS; T42OH008428 United States ACL ACL HHS
المشرفين على المادة: 0 (1-hydroxypyrene-glucuronide)
0 (Air Pollutants)
0 (Glucuronates)
0 (Particulate Matter)
0 (Polycyclic Aromatic Hydrocarbons)
0 (Pyrenes)
6M3C89ZY6R (Nicotine)
AYI8EX34EU (Creatinine)
تواريخ الأحداث: Date Created: 20161215 Date Completed: 20171020 Latest Revision: 20240619
رمز التحديث: 20240619
مُعرف محوري في PubMed: PMC5516642
DOI: 10.1038/jes.2016.57
PMID: 27966668
قاعدة البيانات: MEDLINE
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