دورية أكاديمية
أعرض في EDS

Primary transoral robotic surgery with concurrent neck dissection for early stage oropharyngeal squamous cell carcinoma implemented at a Danish head and neck cancer center: a phase II trial on feasibility and tumour margin status.

التفاصيل البيبلوغرافية
العنوان: Primary transoral robotic surgery with concurrent neck dissection for early stage oropharyngeal squamous cell carcinoma implemented at a Danish head and neck cancer center: a phase II trial on feasibility and tumour margin status.
المؤلفون: Rubek N; Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. Niclas.rubek@regionh.dk., Channir HI; Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Charabi BW; Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Lajer CB; Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Kiss K; Department of Pathology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Nielsen HU; Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Bentzen J; Department of Oncology, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark., Friborg J; Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., von Buchwald C; Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
المصدر: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery [Eur Arch Otorhinolaryngol] 2017 May; Vol. 274 (5), pp. 2229-2237. Date of Electronic Publication: 2017 Jan 03.
نوع المنشور: Clinical Trial, Phase II; Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer International Country of Publication: Germany NLM ID: 9002937 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1434-4726 (Electronic) Linking ISSN: 09374477 NLM ISO Abbreviation: Eur Arch Otorhinolaryngol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Heidelberg : Springer International, c1990-
مواضيع طبية MeSH: Robotic Surgical Procedures*, Carcinoma, Squamous Cell/*surgery , Oropharyngeal Neoplasms/*surgery, Aged ; Antineoplastic Agents/therapeutic use ; Carcinoma, Squamous Cell/drug therapy ; Carcinoma, Squamous Cell/pathology ; Carcinoma, Squamous Cell/radiotherapy ; Cisplatin/therapeutic use ; Combined Modality Therapy ; Denmark ; Feasibility Studies ; Female ; Humans ; Male ; Middle Aged ; Neck Dissection/methods ; Neoplasm Recurrence, Local/radiotherapy ; Neoplasm Recurrence, Local/surgery ; Neoplasm Staging ; Oropharyngeal Neoplasms/drug therapy ; Oropharyngeal Neoplasms/pathology ; Oropharyngeal Neoplasms/radiotherapy
مستخلص: There is an increasing incidence of oropharyngeal squamous cell carcinoma (OPSCC) in the western world due to human papillomavirus (HPV). According to the Danish Head and Neck Cancer Group guidelines, the current recommended treatment of patients with OPSCC in Denmark is primary radiation therapy (RT) with or without concomitant chemotherapy. This is the first study in Scandinavia from a head and neck cancer centre that aims to demonstrate the feasibility of performing primary transoral robotic surgery (TORS) and concurrent neck dissection for patients with early stage OPSCC. Between September 2014 and January 2016, 30 consecutive patients with clinical T1-T2, N0-N1 OPSCC underwent primary TORS and concurrent neck dissection. The patients were offered postoperative adjuvant therapy according to pathological risk parameters: pT >2, T-site margin <2 mm, pN >1 or extracapsular extension (ECE). Concomitant chemotherapy was offered to patients with the presence of ECE or involved margins. Twenty-nine patients had negative margins on T-site after primary resection. Only one patient had a close margin of 1 mm. Unilateral neck dissection was performed in 21 patients while nine patients underwent bilateral neck dissection. Due to an upstaging following surgery, 13 patients were referred to adjuvant therapy. Four of these patients received RT and two patients received concomitant chemo-radiation (CCR) therapy. Seven patients declined the recommended adjuvant therapy one of whom later developed an N-site recurrence and received salvage surgery with postoperative RT. In summary, 43% of the patients were referred to adjuvant therapy following primary surgery which was mainly due to N-site stage migration and ECE. Primary TORS and concurrent neck dissection is a safe and feasible procedure that may be an alternative to primary RT and CCR in a selected group of patients with early stage OPSCC.
References: Oncotarget. 2016 Nov 1;7(44):71761-71772. (PMID: 27708214)
Acta Otolaryngol. 2015;135(10):1051-7. (PMID: 26073750)
Oral Oncol. 2014 Aug;50(8):696-703. (PMID: 24917389)
Head Neck. 2015 Nov;37(11):1618-24. (PMID: 24955923)
JAMA Otolaryngol Head Neck Surg. 2015 Dec;141(12 ):1043-1051. (PMID: 26402479)
Laryngoscope. 2010 Sep;120(9):1749-55. (PMID: 20717944)
BMC Cancer. 2013 Mar 20;13:133. (PMID: 23514246)
Int J Cancer. 2015 May 1;136(9):2196-203. (PMID: 25283302)
Head Neck. 2015 Mar;37(3):381-5. (PMID: 24431059)
Laryngoscope. 2014 Sep;124(9):2096-102. (PMID: 24729006)
Clin Otolaryngol. 2016 Aug;41(4):371-85. (PMID: 26292983)
Laryngoscope. 2011 Mar;121(3):541-4. (PMID: 21344431)
JAMA Otolaryngol Head Neck Surg. 2015 Jun;141(6):499-504. (PMID: 25834991)
Laryngoscope. 2012 Sep;122 Suppl 2:S13-33. (PMID: 22926949)
Int J Cancer. 2016 Dec 1;139(11):2598-605. (PMID: 27537425)
Head Neck. 2016 Apr;38(4):589-600. (PMID: 25488048)
Arch Otolaryngol Head Neck Surg. 2012 Jul;138(7):628-34. (PMID: 22801885)
JAMA Otolaryngol Head Neck Surg. 2013 Nov;139(11):1099-108. (PMID: 23576186)
Arch Otolaryngol Head Neck Surg. 2007 Dec;133(12):1220-6. (PMID: 18086963)
Cancer. 2012 Jul 15;118(14):3519-30. (PMID: 22086669)
BMC Cancer. 2015 Aug 27;15:602. (PMID: 26311526)
Eur Arch Otorhinolaryngol. 2015 Feb;272(2):463-71. (PMID: 24643851)
Eur Arch Otorhinolaryngol. 2015 Jan;272(1):175-83. (PMID: 24609641)
Curr Opin Otolaryngol Head Neck Surg. 2015 Apr;23(2):139-47. (PMID: 25692629)
Br J Cancer. 2015 Jun 30;113(1):131-4. (PMID: 26042932)
J Surg Oncol. 2015 Aug;112(2):155-63. (PMID: 26171771)
Eur J Surg Oncol. 2015 Dec;41(12):1603-14. (PMID: 26461255)
Otolaryngol Head Neck Surg. 2015 Nov;153(5):758-69. (PMID: 26124261)
فهرسة مساهمة: Keywords: Human papillomavirus; Margin status; Oropharyngeal squamous cell carcinoma; Prospective trial; Transoral robotic surgery
المشرفين على المادة: 0 (Antineoplastic Agents)
Q20Q21Q62J (Cisplatin)
تواريخ الأحداث: Date Created: 20170105 Date Completed: 20170531 Latest Revision: 20181202
رمز التحديث: 20221213
DOI: 10.1007/s00405-016-4433-3
PMID: 28050651
قاعدة البيانات: MEDLINE
الوصف
تدمد:1434-4726
DOI:10.1007/s00405-016-4433-3