دورية أكاديمية
Does fall in serum glutathione predict the long-term outcome to concurrent chemoradiation for cervical cancer patients?
| العنوان: | Does fall in serum glutathione predict the long-term outcome to concurrent chemoradiation for cervical cancer patients? |
|---|---|
| المؤلفون: | Narasappa MG; Department of Radiotherapy, Sri Devaraj Urs Medical College, Kolar, Karnataka, India., Gururajachar JM; Department of Radiotherapy, M.S.Ramaiah Medical College, Bengaluru, Karnataka, India., Chokkanna VK; Department of Biochemistry, M.S.Ramaiah Medical College, Bengaluru, Karnataka, India., Somashekar M; Department of Radiotherapy, M.S.Ramaiah Medical College, Bengaluru, Karnataka, India. |
| المصدر: | Journal of cancer research and therapeutics [J Cancer Res Ther] 2016 Jul-Sep; Vol. 12 (3), pp. 1167-1171. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Medknow Publications Country of Publication: India NLM ID: 101249598 Publication Model: Print Cited Medium: Internet ISSN: 1998-4138 (Electronic) Linking ISSN: 19984138 NLM ISO Abbreviation: J Cancer Res Ther Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Mumbai, India : Medknow Publications |
| مواضيع طبية MeSH: | Glutathione/*blood , Uterine Cervical Neoplasms/*blood , Uterine Cervical Neoplasms/*mortality, Adult ; Aged ; Chemoradiotherapy ; Combined Modality Therapy ; Female ; Follow-Up Studies ; Humans ; Middle Aged ; Neoplasm Grading ; Neoplasm Staging ; Prognosis ; Treatment Outcome ; Uterine Cervical Neoplasms/therapy |
| مستخلص: | Background: Wide variations are seen in clinical practice with respect to response to concurrent chemo radiation among cervical cancer patients. Fall in serum glutathione (GSH) level directly correlates with early response to treatment. Whether this early response translates to a better long term outcome is the subject of this prospective study. Materials and Methods: Thirty eight women with cervical cancer were treated with concurrent chemo radiation followed by brachytherapy. Serum GSH was measured before and after two fractions of radiation and first chemotherapy. Patients were followed for a median follow up of four years. Fall in GSH was correlated with response at six weeks and disease status at four years. Results: Median fall in serum GSH was 171.16 µg per ml. Fall in GSH was 170.42, 103.54 and 37.25 µg per ml (P value of <0.0001, 0.05 and 0.18) in patients showing complete response, partial response and no response respectively. Among 26 patients who had no disease at six weeks, 22 women remained disease free at four years (P < 0.0001), two recurred (P < 0.05) and two died of other causes respectively. Non bulky tumours and patients more than 50 years of age showed a fall of 190.69, 265.17 µg per ml respectively. Conclusion: Greater fall in serum GSH predicts better early response as well as long term disease control. |
| المشرفين على المادة: | GAN16C9B8O (Glutathione) |
| تواريخ الأحداث: | Date Created: 20170106 Date Completed: 20170316 Latest Revision: 20170316 |
| رمز التحديث: | 20231215 |
| DOI: | 10.4103/0973-1482.197562 |
| PMID: | 28054530 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1998-4138 |
|---|---|
| DOI: | 10.4103/0973-1482.197562 |