دورية أكاديمية
أعرض في EDS

Characterisation of the opposing effects of G6PD deficiency on cerebral malaria and severe malarial anaemia.

التفاصيل البيبلوغرافية
العنوان: Characterisation of the opposing effects of G6PD deficiency on cerebral malaria and severe malarial anaemia.
المؤلفون: Clarke GM; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.; MRC Centre for Genomics and Global Health, University of Oxford, Oxford, United Kingdom., Rockett K; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.; MRC Centre for Genomics and Global Health, University of Oxford, Oxford, United Kingdom.; The Wellcome Trust Sanger Institute, Cambridge, United Kingdom., Kivinen K; The Wellcome Trust Sanger Institute, Cambridge, United Kingdom., Hubbart C; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom., Jeffreys AE; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom., Rowlands K; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom., Jallow M; Medical Research Council Unit The Gambia, Fajara, Gambia.; Edward Francis Small Teaching Hospital, Independence Drive, Banjul, Gambia., Conway DJ; Medical Research Council Unit The Gambia, Fajara, Gambia.; Department of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom., Bojang KA; Medical Research Council Unit The Gambia, Fajara, Gambia., Pinder M; Medical Research Council Unit The Gambia, Fajara, Gambia., Usen S; Medical Research Council Unit The Gambia, Fajara, Gambia., Sisay-Joof F; Medical Research Council Unit The Gambia, Fajara, Gambia., Sirugo G; Medical Research Council Unit The Gambia, Fajara, Gambia., Toure O; Malaria Research and Training Centre, University of Bamako, Bamako, Mali., Thera MA; Malaria Research and Training Centre, University of Bamako, Bamako, Mali., Konate S; Malaria Research and Training Centre, University of Bamako, Bamako, Mali., Sissoko S; Malaria Research and Training Centre, University of Bamako, Bamako, Mali., Niangaly A; Malaria Research and Training Centre, University of Bamako, Bamako, Mali., Poudiougou B; Malaria Research and Training Centre, University of Bamako, Bamako, Mali., Mangano VD; University of Rome La Sapienza, Rome, Italy., Bougouma EC; Centre National de Recherche et de Formation sur le Paludisme (CNRFP), Ouagadougou, Burkina Faso., Sirima SB; Centre National de Recherche et de Formation sur le Paludisme (CNRFP), Ouagadougou, Burkina Faso., Modiano D; University of Rome La Sapienza, Rome, Italy., Amenga-Etego LN; Navrongo Health Research Centre, Navrongo, Ghana., Ghansah A; Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana., Koram KA; Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana., Wilson MD; Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana., Enimil A; Komfo Anoyke Teaching Hospital, Kumasi, Ghana., Evans J; Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.; Kumasi Centre for Collaborative Research, Kumasi, Ghana., Amodu OK; University of Ibadan, Ibadan, Nigeria., Olaniyan S; University of Ibadan, Ibadan, Nigeria., Apinjoh T; Department of Biochemistry and Molecular Biology, University of Buea, Buea, Cameroon., Mugri R; Department of Medical Laboratory Sciences, University of Buea, Buea, Cameroon., Ndi A; Department of Medical Laboratory Sciences, University of Buea, Buea, Cameroon., Ndila CM; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Uyoga S; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Macharia A; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Peshu N; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Williams TN; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.; Department of Medicine, Faculty of Medicine, Imperial College, London, United Kingdom., Manjurano A; Joint Malaria Programme, Kilimanjaro Christian Medical College, Moshi, Tanzania.; Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom., Sepúlveda N; Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom., Clark TG; Department of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom.; Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom., Riley E; Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom., Drakeley C; Joint Malaria Programme, Kilimanjaro Christian Medical College, Moshi, Tanzania.; Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom., Reyburn H; Joint Malaria Programme, Kilimanjaro Christian Medical College, Moshi, Tanzania.; Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom., Nyirongo V; Malawi-Liverpool Wellcome Trust Clinical Research Programme, University of Malawi, Blantyre, Malawi., Kachala D; Oxford University Clinical Research Unit, University of Oxford, Ho Chi Minh City, Vietnam., Molyneux M; Malawi-Liverpool Wellcome Trust Clinical Research Programme, University of Malawi, Blantyre, Malawi.; Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, United Kingdom., Dunstan SJ; The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Australia., Phu NH; Oxford University Clinical Research Unit, University of Oxford, Ho Chi Minh City, Vietnam.; Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam., Quyen NN; Oxford University Clinical Research Unit, University of Oxford, Ho Chi Minh City, Vietnam., Thai CQ; Oxford University Clinical Research Unit, University of Oxford, Ho Chi Minh City, Vietnam.; Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam., Hien TT; Oxford University Clinical Research Unit, University of Oxford, Ho Chi Minh City, Vietnam.; Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam.; Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea., Manning L; Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea., Laman M; Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea., Siba P; Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea., Karunajeewa H; University of Western Australia, Perth, Australia., Allen S; Swansea University, Swansea, United Kingdom., Allen A; Weatherall Institute of Molecular Medicine, Oxford University, Oxford, United Kingdom., Davis TM; University of Western Australia, Perth, Australia., Michon P; Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea.; Faculty of Medicine and Health Sciences, Divine Word University, Madang, Papua New Guinea., Mueller I; Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea.; Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.; Barcelona Centre for International Health Research, Barcelona, Spain., Molloy SF; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom., Campino S; The Wellcome Trust Sanger Institute, Cambridge, United Kingdom., Kerasidou A; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.; Nuffield Department of Population Health, The Ethox Centre, University of Oxford, Oxford, United Kingdom., Cornelius VJ; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.; MRC Centre for Genomics and Global Health, University of Oxford, Oxford, United Kingdom., Hart L; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom., Shah SS; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, United States., Band G; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.; MRC Centre for Genomics and Global Health, University of Oxford, Oxford, United Kingdom., Spencer CC; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom., Agbenyega T; Komfo Anoyke Teaching Hospital, Kumasi, Ghana.; Kwame Nkrumah University of Science and Technology, Kumasi, Ghana., Achidi E; Department of Medical Laboratory Sciences, University of Buea, Buea, Cameroon., Doumbo OK; Malaria Research and Training Centre, University of Bamako, Bamako, Mali., Farrar J; Oxford University Clinical Research Unit, University of Oxford, Ho Chi Minh City, Vietnam.; Nuffield Department of Clinical Medicine, Center for Tropical Medicine, Oxford University, Oxford, United Kingdom., Marsh K; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Taylor T; Blantyre Malaria Project at the College of Medicine, University of Malawi, Blantyre, Malawi., Kwiatkowski DP; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.; MRC Centre for Genomics and Global Health, University of Oxford, Oxford, United Kingdom.; The Wellcome Trust Sanger Institute, Cambridge, United Kingdom.
مؤلفون مشاركون: MalariaGEN Consortium; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.; The Wellcome Trust Sanger Institute, Cambridge, United Kingdom.
المصدر: ELife [Elife] 2017 Jan 09; Vol. 6. Date of Electronic Publication: 2017 Jan 09.
نوع المنشور: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Cambridge, UK : eLife Sciences Publications, Ltd., 2012-
مواضيع طبية MeSH: Anemia/*epidemiology , Glucosephosphate Dehydrogenase Deficiency/*complications , Malaria, Cerebral/*epidemiology , Malaria, Falciparum/*epidemiology, Alleles ; Anemia/pathology ; Case-Control Studies ; Glucosephosphate Dehydrogenase/genetics ; Humans ; Malaria, Cerebral/pathology ; Malaria, Falciparum/pathology ; Risk Assessment
مستخلص: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is believed to confer protection against Plasmodium falciparum malaria, but the precise nature of the protective effecthas proved difficult to define as G6PD deficiency has multiple allelic variants with different effects in males and females, and it has heterogeneous effects on the clinical outcome of P. falciparum infection. Here we report an analysis of multiple allelic forms of G6PD deficiency in a large multi-centre case-control study of severe malaria, using the WHO classification of G6PD mutations to estimate each individual's level of enzyme activity from their genotype. Aggregated across all genotypes, we find that increasing levels of G6PD deficiency are associated with decreasing risk of cerebral malaria, but with increased risk of severe malarial anaemia. Models of balancing selection based on these findings indicate that an evolutionary trade-off between different clinical outcomes of P. falciparum infection could have been a major cause of the high levels of G6PD polymorphism seen in human populations.
Competing Interests: JF: Director of the Wellcome Trust, one of the three founding funders of eLife. The other authors declare that no competing interests exist.
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معلومات مُعتمدة: G0600718 United Kingdom MRC_ Medical Research Council; G0600230 United Kingdom MRC_ Medical Research Council; 204911/Z/16/Z United Kingdom WT_ Wellcome Trust; MC_UP_A900_1118 United Kingdom MRC_ Medical Research Council; 084538 United Kingdom WT_ Wellcome Trust; G19/9 United Kingdom MRC_ Medical Research Council; MR/M006212/1 United Kingdom MRC_ Medical Research Council; United Kingdom WT_ Wellcome Trust
فهرسة مساهمة: Keywords: G6PD deficiency; epidemiology; evolutionary biology; genetic association; genomics; global health; human; infectious disease; selection
المشرفين على المادة: EC 1.1.1.49 (Glucosephosphate Dehydrogenase)
تواريخ الأحداث: Date Created: 20170110 Date Completed: 20180209 Latest Revision: 20230126
رمز التحديث: 20230127
مُعرف محوري في PubMed: PMC5222559
DOI: 10.7554/eLife.15085
PMID: 28067620
قاعدة البيانات: MEDLINE
الوصف
تدمد:2050-084X
DOI:10.7554/eLife.15085