دورية أكاديمية
أعرض في EDS

Abnormal fetal muscle forces result in defects in spinal curvature and alterations in vertebral segmentation and shape.

التفاصيل البيبلوغرافية
العنوان: Abnormal fetal muscle forces result in defects in spinal curvature and alterations in vertebral segmentation and shape.
المؤلفون: Rolfe RA; Department of Bioengineering, Imperial College London, Prince Consort Road, SW72AZ, London, United Kingdom., Bezer JH; Department of Bioengineering, Imperial College London, Prince Consort Road, SW72AZ, London, United Kingdom., Kim T; Department of Bioengineering, Imperial College London, Prince Consort Road, SW72AZ, London, United Kingdom., Zaidon AZ; Department of Bioengineering, Imperial College London, Prince Consort Road, SW72AZ, London, United Kingdom., Oyen ML; Department of Engineering, University of Cambridge, Cambridge, United Kingdom., Iatridis JC; Department of Orthopaedics, Icahn School of Medicine at Mount Sinai, New York, New York 10029., Nowlan NC; Department of Bioengineering, Imperial College London, Prince Consort Road, SW72AZ, London, United Kingdom.
المصدر: Journal of orthopaedic research : official publication of the Orthopaedic Research Society [J Orthop Res] 2017 Oct; Vol. 35 (10), pp. 2135-2144. Date of Electronic Publication: 2017 May 12.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 8404726 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-527X (Electronic) Linking ISSN: 07360266 NLM ISO Abbreviation: J Orthop Res Subsets: MEDLINE
أسماء مطبوعة: Publication: 2006- : Hoboken, NJ : Wiley
Original Publication: New York, N.Y. : Raven Press, [c1983-
مواضيع طبية MeSH: Fetal Movement*, Spine/*embryology, Animals ; Chick Embryo ; Paralysis
مستخلص: The incidence of congenital spine deformities, including congenital scoliosis, kyphosis, and lordosis, may be influenced by the in utero mechanical environment, and particularly by fetal movements at critical time-points. There is a limited understanding of the influence of fetal movements on spinal development, despite the fact that mechanical forces have been shown to play an essential role in skeletal development of the limb. This study investigates the effects of muscle forces on spinal curvature, vertebral segmentation, and vertebral shape by inducing rigid or flaccid paralysis in the embryonic chick. The critical time-points for the influence of fetal movements on spinal development were identified by varying the time of onset of paralysis. Prolonged rigid paralysis induced severe defects in the spine, including curvature abnormalities, posterior and anterior vertebral fusions, and altered vertebral shape, while flaccid paralysis did not affect spinal curvature or vertebral segmentation. Early rigid paralysis resulted in more severe abnormalities in the spine than later rigid paralysis. The findings of this study support the hypothesis that the timing and nature of fetal muscle activity are critical influences on the normal development of the spine, with implications for the understanding of congenital spine deformities. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:2135-2144, 2017.
(© 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.)
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معلومات مُعتمدة: R01 AR064157 United States AR NIAMS NIH HHS
فهرسة مساهمة: Keywords: chick immobilization; congenital spine deformities; development; flaccid paralysis; muscle forces; rigid paralysis
تواريخ الأحداث: Date Created: 20170113 Date Completed: 20171020 Latest Revision: 20181113
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC5523455
DOI: 10.1002/jor.23518
PMID: 28079273
قاعدة البيانات: MEDLINE
الوصف
تدمد:1554-527X
DOI:10.1002/jor.23518