دورية أكاديمية
Pelvic lymphadenectomy and transperineal interstitial implantation of IR 192 combined with external beam radiotherapy for bulky stage C prostatic carcinoma.
| العنوان: | Pelvic lymphadenectomy and transperineal interstitial implantation of IR 192 combined with external beam radiotherapy for bulky stage C prostatic carcinoma. |
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| المؤلفون: | Brindle JS; Dept of Radiation Oncology, MedCenter One, Bismarck, ND 58501., Martinez A, Schray M, Edmundson G, Benson RC, Zincke H, Diokno A, Gonzalez J |
| المصدر: | International journal of radiation oncology, biology, physics [Int J Radiat Oncol Biol Phys] 1989 Nov; Vol. 17 (5), pp. 1063-6. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier, Inc Country of Publication: United States NLM ID: 7603616 Publication Model: Print Cited Medium: Print ISSN: 0360-3016 (Print) Linking ISSN: 03603016 NLM ISO Abbreviation: Int J Radiat Oncol Biol Phys Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York, NY : Elsevier, Inc Original Publication: Elmsford, N. Y., Pergamon Press. |
| مواضيع طبية MeSH: | Brachytherapy*/adverse effects , Lymph Node Excision*, Iridium Radioisotopes/*therapeutic use , Pelvis/*surgery , Prostatic Neoplasms/*radiotherapy, Adult ; Aged ; Combined Modality Therapy ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Prostatic Neoplasms/mortality ; Prostatic Neoplasms/surgery |
| مستخلص: | From January 1983 until June 1987, 51 patients with locally advanced prostatic carcinoma (47 Stage C, 4 bulky B2) were treated at Mayo Clinic (33 patients) and at William Beaumont Hospital (18 patients) with (a) 5 Gy delivered pre-operatively in one fraction, (b) pelvic lymphadenectomy and (c) interstitial implantation of the prostate with Ir 192 seeds via a perineal template (the Martinez Universal Perineal Interstitial Template) to deliver 35 Gy, and (d) 30.6 Gy external beam therapy in 17 fractions to prostate only fields. Initial clinical response has been excellent. Local control, with a median follow-up of 45 months, has been 100% by clinical exam and 84.5% pathologically in the subset biopsied. Disease-free actuarial survival at 5 years is 89%. Major toxicity has been limited to the rectum, but a modification of the brachytherapy technique has reduced this sharply. We conclude that bulky Stage C prostatic carcinoma can be successfully treated by this aggressive combination of modalities with acceptable toxicity. |
| المشرفين على المادة: | 0 (Iridium Radioisotopes) |
| تواريخ الأحداث: | Date Created: 19891101 Date Completed: 19891130 Latest Revision: 20190708 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/0360-3016(89)90156-9 |
| PMID: | 2808040 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0360-3016 |
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| DOI: | 10.1016/0360-3016(89)90156-9 |