دورية أكاديمية
أعرض في EDS

Luteolin-7-diglucuronide attenuates isoproterenol-induced myocardial injury and fibrosis in mice.

التفاصيل البيبلوغرافية
العنوان: Luteolin-7-diglucuronide attenuates isoproterenol-induced myocardial injury and fibrosis in mice.
المؤلفون: Ning BB; Clinical Research Institute of Integrative Medicine, and Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China., Zhang Y; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China., Wu DD; Clinical Research Institute of Integrative Medicine, and Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China., Cui JG; Clinical Research Institute of Integrative Medicine, and Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China., Liu L; Clinical Research Institute of Integrative Medicine, and Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China., Wang PW; Clinical Research Institute of Integrative Medicine, and Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China., Wang WJ; Clinical Research Institute of Integrative Medicine, and Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China., Zhu WL; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China., Chen Y; Clinical Research Institute of Integrative Medicine, and Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China., Zhang T; Clinical Research Institute of Integrative Medicine, and Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China.
المصدر: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2017 Mar; Vol. 38 (3), pp. 331-341. Date of Electronic Publication: 2017 Jan 23.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol Sin Subsets: MEDLINE
أسماء مطبوعة: Publication: 2009- : New York : Nature Publishing Group
Original Publication: Beijing, China : Science Press, c2000-
مواضيع طبية MeSH: Antioxidants/*pharmacology , Cardiomyopathies/*drug therapy , Cardiotonic Agents/*pharmacology , Glucuronates/*pharmacology , Luteolin/*pharmacology , Myocardium/*pathology, Animals ; Antioxidants/therapeutic use ; Cardiomyopathies/chemically induced ; Cardiomyopathies/pathology ; Cardiotonic Agents/therapeutic use ; Extracellular Matrix Proteins/genetics ; Extracellular Matrix Proteins/metabolism ; Fibrosis/chemically induced ; Fibrosis/pathology ; Fibrosis/prevention & control ; Glucuronates/isolation & purification ; Glucuronates/therapeutic use ; Isoproterenol ; Lamiaceae/chemistry ; Luteolin/isolation & purification ; Luteolin/therapeutic use ; Mice, Inbred C57BL ; MicroRNAs/metabolism ; Necrosis/chemically induced ; Necrosis/drug therapy ; Necrosis/pathology
مستخلص: Myocardial injury and ensuing fibrotic alterations impair normal heart architecture and cause cardiac dysfunction. Oxidative stress has been recognized as a key player in the pathogenesis of cardiac injury and progression of cardiac dysfunction, and promoting fibrosis. In the current study we investigated whether luteolin-7-diglucuronide (L7DG), a naturally occurring antioxidant found in edible plants, could attenuate isoproterenol (ISO)-induced myocardial injury and fibrosis in mice and the underlying mechanisms. Myocardial injury and fibrosis were induced in mice via injection of ISO (5 mg·kg -1 ·d -1 , ip) for 5 or 10 d. Two treatment regimens (pretreatment and posttreatment) were employed to administer L7DG (5-40 mg·kg -1 ·d -1 , ip) into the mice. After the mice were euthanized, morphological examinations of heart sections revealed that both L7DG pretreatment and posttreatment regimens significantly attenuated ISO-induced myocardial injury and fibrosis. But the pretreatment regimen caused better protection against ISO-induced myocardial fibrosis than the posttreatment regimen. Furthermore, L7DG pretreatment blocked ISO-stimulated expression of the genes (Cyba, Cybb, Ncf1, Ncf4 and Rac2) encoding the enzymatic subunits of NADPH oxidase, which was the primary source of oxidant production in mammalian cells. Moreover, L7DG pretreatment significantly suppressed ISO-stimulated expression of collagen genes Col1a1, Col1a2, Col3a1, and Col12a1 and non-collagen extracellular matrix genes fibrillin-1, elastin, collagen triple helix repeat containing 1 and connective tissue growth factor. In addition, L7DG pretreatment almost reversed ISO-altered expression of microRNAs that were crosstalking with TGFβ-mediated fibrosis, including miR-29c-3p, miR-29c-5p, miR-30c-3p, miR-30c-5p and miR-21. The current study demonstrated for the first time that L7DG is pharmacologically effective in protecting the heart against developing ISO-induced injury and fibrosis, justifying further evaluation of L7DG as a cardioprotective agent to treat related cardiovascular diseases.
References: Circ Res. 2007 Mar 30;100(6):894-903. (PMID: 17332431)
Am J Respir Cell Mol Biol. 2015 Feb;52(2):217-31. (PMID: 25029475)
Cell Signal. 2015 Feb;27(2):215-27. (PMID: 25451078)
Mol Cell. 2010 May 14;38(3):323-32. (PMID: 20471939)
Am J Pathol. 1989 Apr;134(4):879-93. (PMID: 2705508)
Arch Pathol. 1972 Apr;93(4):356-65. (PMID: 5017287)
Biochem Biophys Res Commun. 2014 Jun 20;449(1):55-61. (PMID: 24814704)
Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18255-60. (PMID: 17108080)
Circ Res. 2009 Jan 30;104(2):138-40. (PMID: 19179664)
Planta Med. 2001 Feb;67(1):24-8. (PMID: 11270716)
Basic Res Cardiol. 1992;87 Suppl 1:303-9. (PMID: 1497574)
Circulation. 2008 Sep 2;118(10 ):1011-20. (PMID: 18725488)
Fibrogenesis Tissue Repair. 2013 Mar 01;6(1):5. (PMID: 23448358)
Cardiovasc Hematol Disord Drug Targets. 2013 Aug;13(2):165-72. (PMID: 23988004)
Circ Res. 2013 Sep 27;113(8):997-1003. (PMID: 23960241)
Circ Res. 2009 Jan 30;104(2):170-8, 6p following 178. (PMID: 19096030)
AMA Arch Pathol. 1959 Apr;67(4):443-55. (PMID: 13636626)
Annu Rev Biochem. 2010;79:351-79. (PMID: 20533884)
Fibrogenesis Tissue Repair. 2012 Sep 03;5(1):15. (PMID: 22943504)
Fibrogenesis Tissue Repair. 2012 Jun 06;5(Suppl 1):S24. (PMID: 23259531)
Nat Rev Cardiol. 2014 Nov;11(11):655-63. (PMID: 25200283)
Eur J Cell Biol. 2008 Sep;87(8-9):601-15. (PMID: 18342983)
Circ Res. 2007 Mar 30;100(6):826-33. (PMID: 17322174)
Plant Foods Hum Nutr. 2008 Sep;63(3):93-7. (PMID: 18498054)
J Biol Chem. 2013 Apr 12;288(15):10418-26. (PMID: 23426367)
Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13027-32. (PMID: 18723672)
Arterioscler Thromb Vasc Biol. 2012 Feb;32(2):361-9. (PMID: 22095988)
Ann N Y Acad Sci. 1969 Jan 31;156(1):294-308. (PMID: 4400975)
Circulation. 2006 Jun 13;113(23):2733-43. (PMID: 16754804)
Nat Rev Immunol. 2004 Mar;4(3):181-9. (PMID: 15039755)
Circ Res. 1989 Sep;65(3):657-70. (PMID: 2527639)
Pharmacol Ther. 2001 Feb;89(2):187-206. (PMID: 11316520)
J Mol Cell Cardiol. 1985 Apr;17(4):291-306. (PMID: 3894676)
Circ Res. 1994 Jul;75(1):105-13. (PMID: 8013068)
Am J Physiol Heart Circ Physiol. 2005 Sep;289(3):H982-91. (PMID: 15849235)
Front Immunol. 2012 Apr 10;3:71. (PMID: 22566952)
J Clin Invest. 2010 Oct;120(10):3520-9. (PMID: 20811150)
J Am Coll Cardiol. 2006 Nov 21;48(10):1977-85. (PMID: 17112987)
J Pharm Pharmacol. 2009 Nov;61(11):1529-36. (PMID: 19903379)
المشرفين على المادة: 0 (Antioxidants)
0 (Cardiotonic Agents)
0 (Extracellular Matrix Proteins)
0 (Glucuronates)
0 (MicroRNAs)
0 (luteolin 7-diglucuronide)
KUX1ZNC9J2 (Luteolin)
L628TT009W (Isoproterenol)
تواريخ الأحداث: Date Created: 20170124 Date Completed: 20170321 Latest Revision: 20181113
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC5342667
DOI: 10.1038/aps.2016.142
PMID: 28112175
قاعدة البيانات: MEDLINE
الوصف
تدمد:1745-7254
DOI:10.1038/aps.2016.142