دورية أكاديمية
أعرض في EDS

cipC is important for Aspergillus fumigatus virulence.

التفاصيل البيبلوغرافية
العنوان: cipC is important for Aspergillus fumigatus virulence.
المؤلفون: Canela HM; Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil., Takami LA; Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil., da Silva Ferreira ME; Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil.
المصدر: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica [APMIS] 2017 Feb; Vol. 125 (2), pp. 141-147.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Munksgaard Country of Publication: Denmark NLM ID: 8803400 Publication Model: Print Cited Medium: Internet ISSN: 1600-0463 (Electronic) Linking ISSN: 09034641 NLM ISO Abbreviation: APMIS Subsets: MEDLINE
أسماء مطبوعة: Publication: Copenhagen : Munksgaard
Original Publication: Copenhagen : Munksgaard, c1988-
مواضيع طبية MeSH: Aspergillosis/*pathology , Aspergillus fumigatus/*pathogenicity , Fungal Proteins/*metabolism , Virulence Factors/*metabolism, Animals ; Aspergillosis/microbiology ; Aspergillus fumigatus/genetics ; Aspergillus fumigatus/growth & development ; Disease Models, Animal ; Female ; Fungal Proteins/genetics ; Gene Deletion ; Mice, Inbred BALB C ; Virulence ; Virulence Factors/genetics
مستخلص: Aspergillus fumigatus is the main causative agent of invasive aspergillosis, a disease that affects immunocompromised patients and has a high mortality rate. We previously observed that the transcription of a cipC-like gene was increased when A. fumigatus encountered an increased CO 2 concentration, as occurs during the infection process. CipC is a protein of unknown function that might be associated with fungal pathogenicity. In this study, the cipC gene was disrupted in A. fumigatus to evaluate its importance for fungal pathogenicity. The gene was replaced, and the germination, growth phenotype, stress responses, and virulence of the resultant mutant were assessed. Although cipC was not essential, its deletion attenuated A. fumigatus virulence in a low-dose murine infection model, suggesting the involvement of the cipC gene in the virulence of this fungus. This study is the first to disrupt the cipC gene in A. fumigatus.
(© 2017 APMIS. Published by John Wiley & Sons Ltd.)
فهرسة مساهمة: Keywords: Aspergillus fumigatus; cipC; invasive aspergillosis; pathogenicity; virulence
المشرفين على المادة: 0 (Fungal Proteins)
0 (Virulence Factors)
تواريخ الأحداث: Date Created: 20170126 Date Completed: 20170207 Latest Revision: 20170207
رمز التحديث: 20221213
DOI: 10.1111/apm.12648
PMID: 28120495
قاعدة البيانات: MEDLINE
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