دورية أكاديمية
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A theoretical and experimental study of calcium, iron, zinc, cadmium, and sodium ions absorption by aspartame.

التفاصيل البيبلوغرافية
العنوان: A theoretical and experimental study of calcium, iron, zinc, cadmium, and sodium ions absorption by aspartame.
المؤلفون: Mahnam K; Biology Department, Faculty of Sciences, Shehrekord University, Shahrekord, Iran. karimmahnam93@gmail.com., Raisi F; Biology Department, Faculty of Sciences, Payam Nour University, Isfahan, Iran.
المصدر: Journal of biological physics [J Biol Phys] 2017 Mar; Vol. 43 (1), pp. 87-103. Date of Electronic Publication: 2017 Feb 01.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Kluwer Country of Publication: Netherlands NLM ID: 0417731 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-0689 (Electronic) Linking ISSN: 00920606 NLM ISO Abbreviation: J Biol Phys Subsets: MEDLINE
أسماء مطبوعة: Publication: Dordrecht : Kluwer
Original Publication: Blacksburg, Va., University Publications.
مواضيع طبية MeSH: Absorption, Physicochemical* , Molecular Dynamics Simulation*, Aspartame/*chemistry , Metals/*chemistry, Cadmium/chemistry ; Calcium/chemistry ; Iron/chemistry ; Molecular Conformation ; Sodium/chemistry ; Spectrometry, Fluorescence ; Spectrophotometry, Ultraviolet ; Spectrum Analysis ; Static Electricity ; Zinc/chemistry
مستخلص: Aspartame (L-Aspartyl-L-phenylalanine methyl ester) is a sweet dipeptide used in some foods and beverages. Experimental studies show that aspartame causes osteoporosis and some illnesses, which are similar to those of copper and calcium deficiency. This raises the issue that aspartame in food may interact with cations and excrete them from the body. This study aimed to study aspartame interaction with calcium, zinc, iron, sodium, and cadmium ions via molecular dynamics simulation (MD) and spectroscopy. Following a 480-ns molecular dynamics simulation, it became clear that the aspartame is able to sequester Fe 2+ , Ca 2+ , Cd 2+ , and Zn 2+ ions for a long time. Complexation led to increasing UV-Vis absorption spectra and emission spectra of the complexes. This study suggests a potential risk of cationic absorption of aspartame. This study suggests that purification of cadmium-polluted water by aspartame needs a more general risk assessment.
References: Biochim Biophys Acta. 2005 Dec 20;1710(2-3):67-77. (PMID: 16289369)
Environ Sci Technol. 2007 Nov 15;41(22):7609-20. (PMID: 18075065)
J Clin Endocrinol Metab. 1998 Jan;83(1):165-8. (PMID: 9435435)
J Phys Chem B. 2009 Oct 22;113(42):14035-42. (PMID: 19778061)
Carbohydr Res. 2003 May 23;338(11):1217-22. (PMID: 12747864)
Am J Clin Nutr. 1984 Oct;40(4):786-93. (PMID: 6486085)
Int J Environ Res Public Health. 2010 Apr;7(4):1342-65. (PMID: 20617034)
J Biomol Struct Dyn. 2015;33(11):2347-59. (PMID: 26006175)
Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):7063-8. (PMID: 12740433)
BMC Res Notes. 2012 Jul 23;5:367. (PMID: 22824207)
Biopolymers. 2001;60(2):134-52. (PMID: 11455547)
Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W665-7. (PMID: 15215472)
Res Pharm Sci. 2014 Jan-Feb;9(1):69-82. (PMID: 25598801)
Biophys J. 2005 Aug;89(2):768-81. (PMID: 15894639)
Osteoporos Int. 2006 Dec;17(12):1726-33. (PMID: 16983459)
Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4627-31. (PMID: 10781068)
Nature. 2005 May 5;435(7038):42. (PMID: 15875011)
J Mol Graph. 1996 Feb;14(1):33-8, 27-8. (PMID: 8744570)
Acc Chem Res. 2013 Apr 16;46(4):885-93. (PMID: 23214924)
Crit Rev Toxicol. 2007;37(8):629-727. (PMID: 17828671)
Eur J Pediatr. 1989 Aug;148(8):784-5. (PMID: 2792135)
Nature. 1977 Jun 16;267(5612):585-90. (PMID: 301613)
Phys Chem Chem Phys. 2009 Feb 14;11(6):975-83. (PMID: 19177216)
Appl Spectrosc. 2010 Aug;64(8):930-5. (PMID: 20719058)
Nutr Clin Pract. 2008 Apr-May;23(2):128-41. (PMID: 18390780)
Proteins. 2000 Nov 15;41(3):299-315. (PMID: 11025542)
Rev Infect Dis. 1983 Jan-Feb;5(1):137-47. (PMID: 6338570)
Mar Drugs. 2010 Apr 29;8(5):1567-636. (PMID: 20559489)
فهرسة مساهمة: Keywords: Aspartame; Cation absorption; Molecular dynamics simulation; Spectroscopy
المشرفين على المادة: 0 (Metals)
00BH33GNGH (Cadmium)
9NEZ333N27 (Sodium)
E1UOL152H7 (Iron)
J41CSQ7QDS (Zinc)
SY7Q814VUP (Calcium)
Z0H242BBR1 (Aspartame)
تواريخ الأحداث: Date Created: 20170203 Date Completed: 20170828 Latest Revision: 20181113
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC5323347
DOI: 10.1007/s10867-016-9435-2
PMID: 28150114
قاعدة البيانات: MEDLINE
الوصف
تدمد:1573-0689
DOI:10.1007/s10867-016-9435-2