دورية أكاديمية
How does general anaesthesia affect the circadian clock?
| العنوان: | How does general anaesthesia affect the circadian clock? |
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| المؤلفون: | Poulsen RC; Dept of Medicine, University of Auckland, Auckland, New Zealand., Warman GR; Dept of Anaesthesiology, University of Auckland, Auckland, New Zealand., Sleigh J; Dept of Anaesthesiology, University of Auckland, Hamilton, New Zealand., Ludin NM; Dept of Anaesthesiology, University of Auckland, Auckland, New Zealand., Cheeseman JF; Dept of Anaesthesiology, University of Auckland, Auckland, New Zealand. Electronic address: j.cheeseman@auckland.ac.nz. |
| المصدر: | Sleep medicine reviews [Sleep Med Rev] 2018 Feb; Vol. 37, pp. 35-44. Date of Electronic Publication: 2016 Dec 18. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: W.B. Saunders Co Country of Publication: England NLM ID: 9804678 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2955 (Electronic) Linking ISSN: 10870792 NLM ISO Abbreviation: Sleep Med Rev Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London ; Philadelphia : W.B. Saunders Co., c1997- |
| مواضيع طبية MeSH: | Anesthesia, General/*adverse effects , Circadian Clocks/*drug effects , Circadian Rhythm/*drug effects, Animals ; Circadian Clocks/physiology ; Circadian Rhythm/physiology ; Humans ; N-Methylaspartate/metabolism ; gamma-Aminobutyric Acid/metabolism |
| مستخلص: | Post-operative patients experience sleep disturbances. Animal studies demonstrate that general anaesthesia (GA) can disrupt circadian rhythms and cause changes in the molecular clock, indicating that anaesthesia contributes to post-operative circadian disruption. Here we review the effect of anaesthesia on the circadian clock and its rhythms in order to summarise current findings outline commonalities between studies and propose mechanisms by which effects may be mediated. Key Points: 1) GA has strong effects on the main neurotransmitter systems linked with circadian control (Gamma aminobutyric acid/N-methyl-D-aspartate (GABA/NMDA)) and may act by interfering with light-entrainment of the clock. 2) Expression of the core clock gene per2 is inhibited by GA (possibly via a NMDA/glycogen synthase kinase 3β (GSK3β) pathway). 3) GA's effect on circadian rhythms appears greatest when administered during animals' active phases 4) GA may have different effects when administered under free-running and entrained conditions. 5) Anaesthesia may mimic the mechanism involved in adaptation of the clock to changes in daylength. There is agreement that GA can strongly affect the circadian clock. How anaesthesia-induced changes in the molecular clock lead to changes in behaviour remains unclear. The answer, and what it may mean for patients post-operatively, will rely on systematic studies at molecular, behavioural, and clinical levels using standardised protocols. (Copyright © 2016 Elsevier Ltd. All rights reserved.) |
| التعليقات: | Comment in: Sleep Med Rev. 2018 Feb;37:3. (PMID: 28784435) |
| فهرسة مساهمة: | Keywords: Brain and muscle ARNT-like 1; Clock genes; GABA; Hypnotic drugs; NMDA; Post-operative sleep disruption; Sleep/wake cycle; Suprachiasmatic nucleus; Zeitgeber |
| المشرفين على المادة: | 56-12-2 (gamma-Aminobutyric Acid) 6384-92-5 (N-Methylaspartate) |
| تواريخ الأحداث: | Date Created: 20170207 Date Completed: 20181105 Latest Revision: 20181105 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.smrv.2016.12.002 |
| PMID: | 28162920 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1532-2955 |
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| DOI: | 10.1016/j.smrv.2016.12.002 |