دورية أكاديمية
Soy milk versus simvastatin for preventing atherosclerosis and left ventricle remodeling in LDL receptor knockout mice.
العنوان: | Soy milk versus simvastatin for preventing atherosclerosis and left ventricle remodeling in LDL receptor knockout mice. |
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المؤلفون: | Santos L; Unidade Acadêmica de Serra Talhada, Universidade Federal Rural de Pernambuco, Serra Talhada, PE, Brasil.; Departamento de Biologia Estrutural e Funcional, Instituto de Biologia, Universidade de Campinas, Campinas, SP, Brasil., Davel AP; Departamento de Biologia Estrutural e Funcional, Instituto de Biologia, Universidade de Campinas, Campinas, SP, Brasil., Almeida TI; Instituto Federal do Sul de Minas, Muzambinho, MG, Brasil., Almeida MR; Instituto Federal do Sul de Minas, Muzambinho, MG, Brasil., Soares EA; Departamento de Anatomia, Instituto de Ciências Biomédicas, Universidade Federal de Alfenas, Alfenas, MG, Brasil., Fernandes GJ; Departamento de Anatomia, Instituto de Ciências Biomédicas, Universidade Federal de Alfenas, Alfenas, MG, Brasil., Magalhães SF; Departmento de Biomedicina, Universidade José do Rosário Vellano, Alfenas, MG, Brasil., Barauna VG; Departamento de Ciências Fisiológicas, Universidade Federal do Espírito Santo, Vitória, ES, Brasil., Garcia JA; Departmento de Tecnologia, Ciência e Educação, Instituto Federal do Sul de Minas, Machado, MG, Brasil.; Departamento de Fisiologia, Universidade José do Rosário Vellano, Alfenas, MG, Brasil. |
المصدر: | Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas [Braz J Med Biol Res] 2017 Feb 20; Vol. 50 (3), pp. e5854. Date of Electronic Publication: 2017 Feb 20. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Associação Brasileira de Divulgação Científica Country of Publication: Brazil NLM ID: 8112917 Publication Model: Electronic Cited Medium: Internet ISSN: 1414-431X (Electronic) Linking ISSN: 0100879X NLM ISO Abbreviation: Braz J Med Biol Res Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: [SP, Brasil : Associação Brasileira de Divulgação Científica, 1981- |
مواضيع طبية MeSH: | Diet*, Anticholesteremic Agents/*administration & dosage , Atherosclerosis/*prevention & control , Receptors, LDL/*blood , Simvastatin/*administration & dosage , Soy Milk/*administration & dosage , Ventricular Remodeling/*physiology, Animals ; Male ; Mice ; Mice, Knockout |
مستخلص: | Functional food intake has been highlighted as a strategy for the prevention of cardiovascular diseases by reducing risk factors. In this study, we compared the effects of oral treatment with soy milk and simvastatin on dyslipidemia, left ventricle remodeling and atherosclerotic lesion of LDL receptor knockout mice (LDLr-/-) fed a hyperlipidic diet. Forty 3-month old male LDLr-/- mice were distributed into four groups: control group (C), in which animals received standard diet; HL group, in which animals were fed a hyperlipidic diet; HL+SM or HL+S groups, in which animals were submitted to a hyperlipidic diet plus soy milk or simvastatin, respectively. After 60 days, both soy milk and simvastatin treatment prevented dyslipidemia, atherosclerotic lesion progression and left ventricle hypertrophy in LDLr-/- mice. These beneficial effects of soy milk and simvastatin were associated with reduced oxidative stress and inflammatory state in the heart and aorta caused by the hyperlipidic diet. Treatment with soy milk was more effective in preventing HDLc reduction and triacylglycerol and VLDLc increase. On the other hand, simvastatin was more effective in preventing an increase in total cholesterol, LDLc and superoxide production in aorta, as well as CD40L both in aorta and left ventricle of LDLr-/-. In conclusion, our results suggest a cardioprotective effect of soy milk in LDLr-/- mice comparable to the well-known effects of simvastatin. |
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المشرفين على المادة: | 0 (Anticholesteremic Agents) 0 (Receptors, LDL) AGG2FN16EV (Simvastatin) |
تواريخ الأحداث: | Date Created: 20170223 Date Completed: 20171113 Latest Revision: 20181113 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC5333721 |
DOI: | 10.1590/1414-431X20165854 |
PMID: | 28225891 |
قاعدة البيانات: | MEDLINE |
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