دورية أكاديمية
Soy milk versus simvastatin for preventing atherosclerosis and left ventricle remodeling in LDL receptor knockout mice.
| العنوان: | Soy milk versus simvastatin for preventing atherosclerosis and left ventricle remodeling in LDL receptor knockout mice. |
|---|---|
| المؤلفون: | Santos L; Unidade Acadêmica de Serra Talhada, Universidade Federal Rural de Pernambuco, Serra Talhada, PE, Brasil.; Departamento de Biologia Estrutural e Funcional, Instituto de Biologia, Universidade de Campinas, Campinas, SP, Brasil., Davel AP; Departamento de Biologia Estrutural e Funcional, Instituto de Biologia, Universidade de Campinas, Campinas, SP, Brasil., Almeida TI; Instituto Federal do Sul de Minas, Muzambinho, MG, Brasil., Almeida MR; Instituto Federal do Sul de Minas, Muzambinho, MG, Brasil., Soares EA; Departamento de Anatomia, Instituto de Ciências Biomédicas, Universidade Federal de Alfenas, Alfenas, MG, Brasil., Fernandes GJ; Departamento de Anatomia, Instituto de Ciências Biomédicas, Universidade Federal de Alfenas, Alfenas, MG, Brasil., Magalhães SF; Departmento de Biomedicina, Universidade José do Rosário Vellano, Alfenas, MG, Brasil., Barauna VG; Departamento de Ciências Fisiológicas, Universidade Federal do Espírito Santo, Vitória, ES, Brasil., Garcia JA; Departmento de Tecnologia, Ciência e Educação, Instituto Federal do Sul de Minas, Machado, MG, Brasil.; Departamento de Fisiologia, Universidade José do Rosário Vellano, Alfenas, MG, Brasil. |
| المصدر: | Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas [Braz J Med Biol Res] 2017 Feb 20; Vol. 50 (3), pp. e5854. Date of Electronic Publication: 2017 Feb 20. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Associação Brasileira de Divulgação Científica Country of Publication: Brazil NLM ID: 8112917 Publication Model: Electronic Cited Medium: Internet ISSN: 1414-431X (Electronic) Linking ISSN: 0100879X NLM ISO Abbreviation: Braz J Med Biol Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [SP, Brasil : Associação Brasileira de Divulgação Científica, 1981- |
| مواضيع طبية MeSH: | Diet*, Anticholesteremic Agents/*administration & dosage , Atherosclerosis/*prevention & control , Receptors, LDL/*blood , Simvastatin/*administration & dosage , Soy Milk/*administration & dosage , Ventricular Remodeling/*physiology, Animals ; Male ; Mice ; Mice, Knockout |
| مستخلص: | Functional food intake has been highlighted as a strategy for the prevention of cardiovascular diseases by reducing risk factors. In this study, we compared the effects of oral treatment with soy milk and simvastatin on dyslipidemia, left ventricle remodeling and atherosclerotic lesion of LDL receptor knockout mice (LDLr-/-) fed a hyperlipidic diet. Forty 3-month old male LDLr-/- mice were distributed into four groups: control group (C), in which animals received standard diet; HL group, in which animals were fed a hyperlipidic diet; HL+SM or HL+S groups, in which animals were submitted to a hyperlipidic diet plus soy milk or simvastatin, respectively. After 60 days, both soy milk and simvastatin treatment prevented dyslipidemia, atherosclerotic lesion progression and left ventricle hypertrophy in LDLr-/- mice. These beneficial effects of soy milk and simvastatin were associated with reduced oxidative stress and inflammatory state in the heart and aorta caused by the hyperlipidic diet. Treatment with soy milk was more effective in preventing HDLc reduction and triacylglycerol and VLDLc increase. On the other hand, simvastatin was more effective in preventing an increase in total cholesterol, LDLc and superoxide production in aorta, as well as CD40L both in aorta and left ventricle of LDLr-/-. In conclusion, our results suggest a cardioprotective effect of soy milk in LDLr-/- mice comparable to the well-known effects of simvastatin. |
| References: | Clin Chem. 1972 Jun;18(6):499-502. (PMID: 4337382) J Cardiovasc Pharmacol. 2008 Jan;51(1):78-85. (PMID: 18209572) Nutr Rev. 2003 Jun;61(6 Pt 1):189-203. (PMID: 12903829) J Lipid Res. 1988 Dec;29(12):1573-82. (PMID: 2468730) Nutr Res. 2016 Aug;36(8):879-84. (PMID: 27440543) Oxid Med Cell Longev. 2009 Nov-Dec;2(5):259-69. (PMID: 20716913) Arq Bras Cardiol. 2013 Oct;101(4 Suppl 1):1-20. (PMID: 24217493) Rev Port Cardiol. 2011 Oct;30(10):763-9. (PMID: 22118127) Int J Exp Pathol. 2014 Aug;95(4):296-308. (PMID: 24853046) Nature. 2000 Sep 14;407(6801):233-41. (PMID: 11001066) Atherosclerosis. 1987 Dec;68(3):231-40. (PMID: 3426656) Circ Res. 2004 Oct 15;95(8):764-72. (PMID: 15486323) Nature. 1998 Feb 5;391(6667):591-4. (PMID: 9468137) J Agric Food Chem. 2010 Apr 14;58(7):4284-91. (PMID: 20199084) J Am Coll Cardiol. 1998 Sep;32(3):704-10. (PMID: 9741515) J Biol Chem. 2004 Aug 6;279(32):33586-92. (PMID: 15173162) J Am Coll Cardiol. 2000 Jan;35(1):36-44. (PMID: 10636256) Mol Endocrinol. 2001 Nov;15(11):1864-9. (PMID: 11682617) J Nutr. 1995 Mar;125(3 Suppl):639S-646S. (PMID: 7884546) Atherosclerosis. 2001 Jul;157(1):23-9. (PMID: 11427200) Biochem Biophys Res Commun. 2006 Jul 7;345(3):1004-9. (PMID: 16712797) Biochim Biophys Acta. 2010 Feb;1801(2):183-90. (PMID: 19913637) Toxicol Mech Methods. 2005;15(2):61-92. (PMID: 20021068) Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3106-10. (PMID: 9501223) Arterioscler Thromb Vasc Biol. 2002 Oct 1;22(10):1524-34. (PMID: 12377727) Am J Clin Nutr. 1998 Dec;68(6 Suppl):1333S-1346S. (PMID: 9848496) Arterioscler Thromb Vasc Biol. 2005 Jan;25(1):29-38. (PMID: 15539615) Methods Enzymol. 2002;352:432-54. (PMID: 12125370) Nitric Oxide. 2006 Feb;14(1):12-20. (PMID: 16198610) JAMA. 2003 Apr 2;289(13):1681-90. (PMID: 12672737) J Lipid Res. 2001 Apr;42(4):563-70. (PMID: 11290828) Arterioscler Thromb Vasc Biol. 1997 Nov;17(11):2868-74. (PMID: 9409268) Curr Atheroscler Rep. 2012 Jun;14(3):264-76. (PMID: 22350585) |
| المشرفين على المادة: | 0 (Anticholesteremic Agents) 0 (Receptors, LDL) AGG2FN16EV (Simvastatin) |
| تواريخ الأحداث: | Date Created: 20170223 Date Completed: 20171113 Latest Revision: 20181113 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC5333721 |
| DOI: | 10.1590/1414-431X20165854 |
| PMID: | 28225891 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder كن أول من يترك تعليقا!