دورية أكاديمية
Bile acid sequestrants for glycemic control in patients with type 2 diabetes: A systematic review with meta-analysis of randomized controlled trials.
| العنوان: | Bile acid sequestrants for glycemic control in patients with type 2 diabetes: A systematic review with meta-analysis of randomized controlled trials. |
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| المؤلفون: | Hansen M; Center for Diabetes Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark; NNF Center for Basic Metabolic Research and Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Sonne DP; Center for Diabetes Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark., Mikkelsen KH; Center for Diabetes Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark; NNF Center for Basic Metabolic Research and Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Gluud LL; Center for Diabetes Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark; Gastro Unit, Medical Division, Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark., Vilsbøll T; Center for Diabetes Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Knop FK; Center for Diabetes Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark; NNF Center for Basic Metabolic Research and Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address: filipknop@dadlnet.dk. |
| المصدر: | Journal of diabetes and its complications [J Diabetes Complications] 2017 May; Vol. 31 (5), pp. 918-927. Date of Electronic Publication: 2017 Jan 24. |
| نوع المنشور: | Journal Article; Meta-Analysis; Review; Systematic Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Pub. Co Country of Publication: United States NLM ID: 9204583 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-460X (Electronic) Linking ISSN: 10568727 NLM ISO Abbreviation: J Diabetes Complications Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY : Elsevier Science Pub. Co., c1992- |
| مواضيع طبية MeSH: | Bile Acids and Salts/*antagonists & inhibitors , Diabetes Mellitus, Type 2/*drug therapy , Hyperglycemia/*prevention & control , Hypoglycemia/*prevention & control , Hypoglycemic Agents/*therapeutic use , Sequestering Agents/*therapeutic use, Bile Acids and Salts/adverse effects ; Colesevelam Hydrochloride/adverse effects ; Colesevelam Hydrochloride/therapeutic use ; Diabetes Mellitus, Type 2/blood ; Epichlorohydrin/adverse effects ; Epichlorohydrin/therapeutic use ; Glycated Hemoglobin/analysis ; Humans ; Hypoglycemia/chemically induced ; Hypoglycemic Agents/adverse effects ; Imidazoles/adverse effects ; Imidazoles/therapeutic use ; Randomized Controlled Trials as Topic ; Reproducibility of Results ; Resins, Synthetic/adverse effects ; Resins, Synthetic/therapeutic use ; Sequestering Agents/adverse effects |
| مستخلص: | Aim: To evaluate the effects of bile acid sequestrants (BASs) versus placebo, no intervention or active comparators on glycemic control in type 2 diabetes. Methods: Data were retrieved and a systematic review with meta-analyses was performed. We evaluated bias control and subgroup and sensitivity analyses were performed to evaluate heterogeneity and bias. Results: We included 17 trials with a total of 2950 patients randomized to BASs (colesevelam or colestimide) versus placebo, no intervention, statins or sitagliptin. Random-effects meta-analysis showed that patients randomized to BASs had a lower hemoglobin A Conclusions: Our analyses found that BAS treatment improves glycemic control. The size of the effect was clinically relevant and despite limited safety data, our findings support the inclusion of BASs in current diabetes management algorithms for type 2 diabetes. (Copyright © 2017 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Bile acid sequestrants; Colesevelam; Colestimide; Glycemic control; Meta-analysis; Type 2 diabetes |
| المشرفين على المادة: | 0 (Bile Acids and Salts) 0 (Glycated Hemoglobin A) 0 (Hypoglycemic Agents) 0 (Imidazoles) 0 (Resins, Synthetic) 0 (Sequestering Agents) 0 (colestimide) 0 (hemoglobin A1c protein, human) 08OOR508C0 (Epichlorohydrin) P4SG24WI5Q (Colesevelam Hydrochloride) |
| تواريخ الأحداث: | Date Created: 20170228 Date Completed: 20180309 Latest Revision: 20221207 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.jdiacomp.2017.01.011 |
| PMID: | 28238556 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1873-460X |
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| DOI: | 10.1016/j.jdiacomp.2017.01.011 |