دورية أكاديمية
Disease impact on the quality of life of children with inflammatory bowel disease.
| العنوان: | Disease impact on the quality of life of children with inflammatory bowel disease. |
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| المؤلفون: | Chouliaras G; Giorgos Chouliaras, Daphne Margoni, Konstantina Dimakou, Smaragdi Fessatou, Ioanna Panayiotou, Eleftheria Roma-Giannikou, First Department of Pediatrics, National and Kapodistrian University of Athens, 'Aghia Sophia' Children's Hospital, 11527 Athens, Greece., Margoni D; Giorgos Chouliaras, Daphne Margoni, Konstantina Dimakou, Smaragdi Fessatou, Ioanna Panayiotou, Eleftheria Roma-Giannikou, First Department of Pediatrics, National and Kapodistrian University of Athens, 'Aghia Sophia' Children's Hospital, 11527 Athens, Greece., Dimakou K; Giorgos Chouliaras, Daphne Margoni, Konstantina Dimakou, Smaragdi Fessatou, Ioanna Panayiotou, Eleftheria Roma-Giannikou, First Department of Pediatrics, National and Kapodistrian University of Athens, 'Aghia Sophia' Children's Hospital, 11527 Athens, Greece., Fessatou S; Giorgos Chouliaras, Daphne Margoni, Konstantina Dimakou, Smaragdi Fessatou, Ioanna Panayiotou, Eleftheria Roma-Giannikou, First Department of Pediatrics, National and Kapodistrian University of Athens, 'Aghia Sophia' Children's Hospital, 11527 Athens, Greece., Panayiotou I; Giorgos Chouliaras, Daphne Margoni, Konstantina Dimakou, Smaragdi Fessatou, Ioanna Panayiotou, Eleftheria Roma-Giannikou, First Department of Pediatrics, National and Kapodistrian University of Athens, 'Aghia Sophia' Children's Hospital, 11527 Athens, Greece., Roma-Giannikou E; Giorgos Chouliaras, Daphne Margoni, Konstantina Dimakou, Smaragdi Fessatou, Ioanna Panayiotou, Eleftheria Roma-Giannikou, First Department of Pediatrics, National and Kapodistrian University of Athens, 'Aghia Sophia' Children's Hospital, 11527 Athens, Greece. |
| المصدر: | World journal of gastroenterology [World J Gastroenterol] 2017 Feb 14; Vol. 23 (6), pp. 1067-1075. |
| نوع المنشور: | Journal Article; Observational Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Baishideng Publishing Group Country of Publication: United States NLM ID: 100883448 Publication Model: Print Cited Medium: Internet ISSN: 2219-2840 (Electronic) Linking ISSN: 10079327 NLM ISO Abbreviation: World J Gastroenterol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2014- : Pleasanton, CA : Baishideng Publishing Group Original Publication: Beijing : WJG Press, c1998- |
| مواضيع طبية MeSH: | Quality of Life*, Colitis, Ulcerative/*complications , Crohn Disease/*complications, Adolescent ; Age Factors ; Child ; Colitis, Ulcerative/psychology ; Crohn Disease/psychology ; Cross-Sectional Studies ; Emotions ; Female ; Hospitalization ; Humans ; Male ; Risk Factors ; Severity of Illness Index ; Surveys and Questionnaires ; Time Factors |
| مستخلص: | Aim: To assess the impact of disease characteristics on the quality of life (QOL) in children with inflammatory bowel diseases (IBD). Methods: This was a cross-sectional study conducted at the First Department of Pediatrics of the University of Athens at the "Aghia Sophia" Children's Hospital. Children diagnosed with Crohn's disease (CD) or ulcerative colitis (UC), who were followed as outpatients or during a hospitalization, participated, after informed consent was obtained from their legal representative. QOL was assessed by the IMPACT-III questionnaire. Demographic data and disease characteristics were also collected. Statistical analyses included parametric (Student's t -test and Pearson's r ) and non-parametric (Mann-Whitney test, Fisher's test and Spearman's rho) procedures. Results: Ninety-nine patients (UC: 37, 73.0% females, CD: 62, 51.6% females), aged 12.8 ± 2.6 years were included. Overall, as well as, sub-domain scores did not differ between UC and CD (overall score: 73.9 ± 13.3 vs 77.5 ± 11.2, respectively, P = 0.16). In the entire sample, total score was related to physician's global assessment (PGA, patients classified as "mild/moderate" active disease had, on average, 14.8 ± 2.7 points lower total scores compared to those "in remission", P < 0.001) and age at IMPACT completion (Pearson's r = 0.29, P = 0.05). Disease activity assessed by the indices Pediatric Ulcerative Colitis activity index, Pediatric Crohn's disease activity index or PGA was significantly associated with all subdomains scores. Presence of extraintestinal manifestations had a negative impact on emotional and social functioning domains. Conclusion: Disease activity is the main correlate of QOL in children with IBD, underlining the importance of achieving and sustaining clinical remission. Competing Interests: Conflict-of-interest statement: There are no conflicts of interest to report. |
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| فهرسة مساهمة: | Keywords: Crohn’s disease; IMPACT-III; Inflammatory bowel disease; children; quality of life; ulcerative colitis |
| SCR Disease Name: | Pediatric Crohn's disease; Pediatric ulcerative colitis |
| تواريخ الأحداث: | Date Created: 20170302 Date Completed: 20170811 Latest Revision: 20220409 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC5311096 |
| DOI: | 10.3748/wjg.v23.i6.1067 |
| PMID: | 28246481 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2219-2840 |
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| DOI: | 10.3748/wjg.v23.i6.1067 |