دورية أكاديمية
Donor-Recipient Weight and Sex Mismatch and the Risk of Graft Loss in Renal Transplantation.
| العنوان: | Donor-Recipient Weight and Sex Mismatch and the Risk of Graft Loss in Renal Transplantation. |
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| المؤلفون: | Miller AJ; Department of Medicine, Division of Nephrology, and., Kiberd BA; Department of Medicine, Division of Nephrology, and., Alwayn IP; Department of General Surgery, Nova Scotia Health Authority, Halifax, Nova Scotia, Canada; and., Odutayo A; Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom., Tennankore KK; Department of Medicine, Division of Nephrology, and. |
| المصدر: | Clinical journal of the American Society of Nephrology : CJASN [Clin J Am Soc Nephrol] 2017 Apr 03; Vol. 12 (4), pp. 669-676. Date of Electronic Publication: 2017 Mar 30. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wolters Kluwer Health Country of Publication: United States NLM ID: 101271570 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1555-905X (Electronic) Linking ISSN: 15559041 NLM ISO Abbreviation: Clin J Am Soc Nephrol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2023- : Hagerstown, MD : Wolters Kluwer Health Original Publication: Washington, D.C. : American Society of Nephrology, c2005- |
| مواضيع طبية MeSH: | Body Weight* , Graft Survival* , Tissue Donors* , Transplant Recipients*, Kidney Transplantation/*statistics & numerical data, Adult ; Cohort Studies ; Female ; Humans ; Male ; Middle Aged ; Proportional Hazards Models ; Registries ; Risk Factors ; Sex Factors ; United States |
| مستخلص: | Background and Objectives: Relatively smaller kidney donor to recipient size is proposed to result in higher graft loss due to nephron underdosing and hyperfiltration injury, but the potentially additive effect of sex and weight mismatch has not been explored in detail. The purpose of this study was to determine if concurrent donor and recipient absolute weight and sex mismatch was associated with graft loss in a cohort of deceased donor kidney transplant recipients. Design, Setting, Participants, & Measurements: The association of kidney donor and recipient absolute weight and sex difference with death-censored graft loss was explored using a cohort of United States deceased donor recipients between 2000 and 2014 through the Scientific Registry of Transplants Recipients. Donor-recipient sex pairings (male donor-male recipient; female donor-female recipient; male donor-female recipient; female donor-male recipient) were further stratified by donor and recipient absolute weight difference (>30 or 10-30 kg [donor Results: Of 115,124 kidney transplant recipients, 21,261 developed death-censored graft failure (median graft survival time was 3.8 years; quartile 1 to 3, 0.0 to 14.8 years). After multivariable adjustment, the highest relative hazards for graft failure were observed for female recipients of male donor kidneys and male recipients of female donor kidneys in situations where the recipient was >30 kg larger than donor (hazard ratio, 1.50; 95% confidence interval, 1.32 to 1.70; hazard ratio, 1.35; 95% confidence interval, 1.25 to 1.45, respectively). Conclusions: A concurrent mismatch in donor-recipient weight (donor |
| التعليقات: | Comment in: Clin J Am Soc Nephrol. 2017 Apr 3;12 (4):565-567. (PMID: 28360197) |
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| فهرسة مساهمة: | Keywords: United States; female; graft failure; graft survival; kidney; kidney transplantation; male; nephrons; proportional hazards models; registries; sex characteristics; sex mismatch; size mismatch; tissue donors; transplant recipients |
| تواريخ الأحداث: | Date Created: 20170401 Date Completed: 20171219 Latest Revision: 20230813 |
| رمز التحديث: | 20230813 |
| مُعرف محوري في PubMed: | PMC5383387 |
| DOI: | 10.2215/CJN.07660716 |
| PMID: | 28360198 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1555-905X |
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| DOI: | 10.2215/CJN.07660716 |