دورية أكاديمية
أعرض في EDS

Effects of Selenium Supplementation on the Diabetic Condition Depend on the Baseline Selenium Status in KKAy Mice.

التفاصيل البيبلوغرافية
العنوان: Effects of Selenium Supplementation on the Diabetic Condition Depend on the Baseline Selenium Status in KKAy Mice.
المؤلفون: Febiyanto N; Department of Public Health, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.; Department of Public Health, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia., Yamazaki C; Department of Public Health, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan., Kameo S; Department of Public Health, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan., Sari DK; Department of Public Health, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.; Department of Public Health, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia., Puspitasari IM; Department of Public Health, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.; Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Bandung, Indonesia., Sunjaya DK; Department of Public Health, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia., Herawati DMD; Department of Public Health, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia., Nugraha GI; Department of Biochemistry, Faculty of Medicine Universitas Padjadjaran, Bandung, Indonesia., Fukuda T; Department of Histopathology and Cytopathology, Gunma University Graduate School of Health Sciences, Maebashi, Japan., Koyama H; Department of Public Health, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan. hkoyama@gunma-u.ac.jp.
المصدر: Biological trace element research [Biol Trace Elem Res] 2018 Jan; Vol. 181 (1), pp. 71-81. Date of Electronic Publication: 2017 Apr 20.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Humana Press Country of Publication: United States NLM ID: 7911509 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-0720 (Electronic) Linking ISSN: 01634984 NLM ISO Abbreviation: Biol Trace Elem Res Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London, Clifton, N. J.] Humana Press.
مواضيع طبية MeSH: Dietary Supplements*, Diabetes Mellitus, Type 2/*prevention & control , Selenium/*analysis , Selenomethionine/*pharmacology, Animals ; Diabetes Mellitus, Type 2/pathology ; Male ; Mice ; Mice, Inbred Strains ; Selenomethionine/administration & dosage
مستخلص: Oxidative stress in obesity leads to insulin resistance in type 2 diabetes. Some selenoproteins possess antioxidant properties, suggesting that selenium (Se) may protect against type 2 diabetes; however, evidence from epidemiological studies is contradictory. We hypothesized that Se status before supplementation (baseline) contributes to the supplementation outcome. This study aimed to clarify the influence of baseline Se status on the effect of Se supplementation on the diabetic condition. Six-week-old KKAy mice were fed a diet without supplemental Se or with 0.1 ppm Se in the form of L-selenomethionine (SeM) for 2 weeks to create low-Se and sufficient-Se baseline statuses, respectively. For the next 4 weeks, low-Se mice were given a SeM (0.5 ppm Se)-supplemented diet, and sufficient-Se mice were given either a SeM (0.5 ppm Se)- or sodium selenite (0.5 ppm Se)-supplemented diet; control groups continued on baseline diets. Serum Se concentrations, glutathione peroxidase (GPx) activities, adiponectin levels, glucose tolerance, and insulin sensitivity were analyzed. All mice became diabetic during the 2-week baseline induction period. At the end of the supplementation period, Se-receiving groups demonstrated significantly higher Se concentrations and GPx activities than their respective controls. Sufficient-Se mice receiving SeM had lower blood glucose levels and better insulin sensitivity than control and sodium selenite-receiving mice, whereas low-Se mice receiving SeM showed no such improvements compared with their controls. Our results suggest that Se supplementation in the form of SeM may help prevent type 2 diabetes aggravation in people taking the 55 μg/day Se recommended dietary allowance.
فهرسة مساهمة: Keywords: Glucose tolerance; Glutathione peroxidase; Insulin sensitivity; Selenium; Selenomethionine; Type 2 diabetes
المشرفين على المادة: 964MRK2PEL (Selenomethionine)
H6241UJ22B (Selenium)
تواريخ الأحداث: Date Created: 20170422 Date Completed: 20180718 Latest Revision: 20220408
رمز التحديث: 20240829
DOI: 10.1007/s12011-017-1013-3
PMID: 28429286
قاعدة البيانات: MEDLINE
الوصف
تدمد:1559-0720
DOI:10.1007/s12011-017-1013-3