Vena contracta area for severity grading in functional and degenerative mitral regurgitation: a transoesophageal 3D colour Doppler analysis in 500 patients.

التفاصيل البيبلوغرافية
العنوان:	Vena contracta area for severity grading in functional and degenerative mitral regurgitation: a transoesophageal 3D colour Doppler analysis in 500 patients.
المؤلفون:	Goebel B; Divisions of Cardiology, Angiology, Pneumology, and Intensive Medical Care, Department of Internal Medicine 1, Friedrich-Schiller-University of Jena, Erlanger Allee 101, D-07740 Jena, Germany., Heck R; Divisions of Cardiology, Angiology, Pneumology, and Intensive Medical Care, Department of Internal Medicine 1, Friedrich-Schiller-University of Jena, Erlanger Allee 101, D-07740 Jena, Germany., Hamadanchi A; Divisions of Cardiology, Angiology, Pneumology, and Intensive Medical Care, Department of Internal Medicine 1, Friedrich-Schiller-University of Jena, Erlanger Allee 101, D-07740 Jena, Germany., Otto S; Divisions of Cardiology, Angiology, Pneumology, and Intensive Medical Care, Department of Internal Medicine 1, Friedrich-Schiller-University of Jena, Erlanger Allee 101, D-07740 Jena, Germany., Doenst T; Department of Cardiothoracic Surgery, Jena University Hospital-Friedrich Schiller University of Jena, Erlanger Allee 101, 07747 Jena, Germany., Jung C; University Hospital Düsseldorf, Department of Medicine, Division of Cardiology, Pulmonary Diseases and Vascular Medicine, Moorenstr. 5, D-40225 Düsseldorf, Germany., Lauten A; Charité-Universitaetsmedizin Berlin, Department of Cardiology Berlin, Campus Benjamin Franklin, Germany., Figulla HR; Divisions of Cardiology, Angiology, Pneumology, and Intensive Medical Care, Department of Internal Medicine 1, Friedrich-Schiller-University of Jena, Erlanger Allee 101, D-07740 Jena, Germany., Schulze PC; Divisions of Cardiology, Angiology, Pneumology, and Intensive Medical Care, Department of Internal Medicine 1, Friedrich-Schiller-University of Jena, Erlanger Allee 101, D-07740 Jena, Germany., Poerner TC; Divisions of Cardiology, Angiology, Pneumology, and Intensive Medical Care, Department of Internal Medicine 1, Friedrich-Schiller-University of Jena, Erlanger Allee 101, D-07740 Jena, Germany.
المصدر:	European heart journal. Cardiovascular Imaging [Eur Heart J Cardiovasc Imaging] 2018 Jun 01; Vol. 19 (6), pp. 639-646.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Oxford University Press Country of Publication: England NLM ID: 101573788 Publication Model: Print Cited Medium: Internet ISSN: 2047-2412 (Electronic) Linking ISSN: 20472404 NLM ISO Abbreviation: Eur Heart J Cardiovasc Imaging Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: Oxford : Oxford University Press
مواضيع طبية MeSH:	Echocardiography, Doppler, Color/methods , Echocardiography, Three-Dimensional/methods , Echocardiography, Transesophageal/methods , Image Interpretation, Computer-Assisted/methods , Mitral Valve Insufficiency/diagnostic imaging , Mitral Valve Insufficiency/physiopathology, Aged ; Area Under Curve ; Blood Flow Velocity ; Cohort Studies ; Confidence Intervals ; Female ; Humans ; Male ; Middle Aged ; ROC Curve ; Retrospective Studies ; Sensitivity and Specificity ; Severity of Illness Index ; Stroke Volume/physiology ; Vascular Resistance
مستخلص:	Aims: Vena contracta area (VCA3D), derived by 3D colour Doppler echocardiography, has already been validated against cardiac magnetic resonance imaging, but the number of clinical studies to define cut-off values for grading of mitral regurgitation (MR) is limited. Aim of the study was to assess VCA3D in a large population of patients with functional (FMR) and degenerative MR (DMR). Methods and Results: Transoesophageal echocardiography was performed in 500 patients with MR. The following 2D parameters were assessed for grading of MR: vena contracta width, effective regurgitant orifice area (EROAPISA), and regurgitation volume (RVPISA). VCA3D and the corresponding regurgitation volume (RVVCA) were quantified using 3D colour Doppler loop and CW Doppler tracing of the regurgitant jet. In 104 patients a 3D dataset of the left ventricle (LV) and the left ventricular outflow tract (LVOT) was acquired. As a reference method, regurgitation volume (RV3D) was calculated as difference between LV overall and LVOT stroke volumes. For prediction of severe MR, VCA3D yielded higher values of area under the ROC curve compared to EROAPISA (overall patient group 0.98 for VCA3D vs. 0.90 for EROAPISA, P < 0.001; FMR group 0.97 for VCA3D vs. 0.92 for EROAPISA, P = 0.002). RVVCA correlated closer with RV3D compared to RVPISA (r = 0.96 for RVPISA, r = 0.79 for RVPISA). Conclusion: This study delivers cut-off values for VCA3D in patients with different types of MR. VCA3D is a robust parameter for quantification of MR, showing a good correlation with the reference method using 3D datasets of LV.
تواريخ الأحداث:	Date Created: 20170427 Date Completed: 20190218 Latest Revision: 20190219
رمز التحديث:	20240829
DOI:	10.1093/ehjci/jex056
PMID:	28444164
قاعدة البيانات:	MEDLINE

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تدمد:	2047-2412
DOI:	10.1093/ehjci/jex056