دورية أكاديمية
أعرض في EDS

Colonisation of antibiotic resistant bacteria in a cohort of HIV infected children in Ghana.

التفاصيل البيبلوغرافية
العنوان: Colonisation of antibiotic resistant bacteria in a cohort of HIV infected children in Ghana.
المؤلفون: Sampane-Donkor E; Department of Medical Microbiology, School of Biomedical and Allied Health Sciences University of Ghana, Accra, Ghana., Badoe EV; Department of Child Health, School of Medicine and Dentistry, University of Ghana Accra, Ghana., Annan JA; Department of Medical Microbiology, School of Biomedical and Allied Health Sciences University of Ghana, Accra, Ghana., Nii-Trebi N; Department of Medical Laboratory Science, School of Biomedical and Allied Health Sciences, University of Ghana, Accra, Ghana.
المصدر: The Pan African medical journal [Pan Afr Med J] 2017 Feb 02; Vol. 26, pp. 60. Date of Electronic Publication: 2017 Feb 02 (Print Publication: 2017).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: African Field Epidemiology Network Country of Publication: Uganda NLM ID: 101517926 Publication Model: eCollection Cited Medium: Internet ISSN: 1937-8688 (Electronic) NLM ISO Abbreviation: Pan Afr Med J Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Kampala, Uganda : African Field Epidemiology Network
مواضيع طبية MeSH: Anti-Bacterial Agents/*pharmacology , Bacteria/*isolation & purification , Bacterial Infections/*epidemiology , HIV Infections/*complications, Adolescent ; Bacterial Infections/microbiology ; Child ; Child, Preschool ; Drug Resistance, Bacterial ; Drug Resistance, Multiple, Bacterial ; Female ; Ghana/epidemiology ; Humans ; Male ; Microbial Sensitivity Tests ; Nasopharynx/microbiology ; Prevalence
مستخلص: Antibiotic use not only selects for resistance in pathogenic bacteria, but also in commensal flora of exposed individuals. Little is known epidemiologically about antibiotic resistance in relation to people with HIV infection in sub-Saharan Africa. This study investigated the carriage of antibiotic resistant bacteria among HIV infected children at a tertiary hospital in Ghana. One hundred and eighteen HIV positive children were recruited at the Korle-Bu Teaching Hospital in Ghana and nasopharyngeal specimens were collected from them. The specimens were cultured for bacteria, and the isolates were identified by standard microbiological methods. Antibiotic susceptibility tests were carried out on selected bacterial organisms by the Kirby Bauer method. Bacteria isolated from the study subjects included Moraxella catarrhalis (39.8%), coagulase negative staphylococci (33.1%), Streptococcus pneumoniae (30.5%), diptheroids (29.7%), viridian streptococci (27.1%), Staphylococcus aureus (22.0%), Citrobacter spp. (4.2%) and Neisseria meningitidis (0.9%). Prevalence of antibiotic resistance of S. pneumoniae ranged from 5.6% (ceftriaxone) to 58.3% (cotrimoxazole), M. catarrhalis ranged from 2.1% (gentamicin) to 80.6% (ampicillin), and S. aureus ranged from 7.7% (cefoxitin) to 100% (penicillin). The prevalence of multiple drug resistance was 16.7% for S. pneumoniae, 57.4% for M. catarrhalis and 84.6% for S. aureus. HIV infected children in the study area commonly carry multi-drug resistant isolates of several pathogenic bacteria such as S. aureus and S. pneumoniae. Infections arising in these patients that are caused by S. aureus and S. pneumoniae could be treated with ceftriaxone and cefoxitin respectively.
Competing Interests: The authors declare no competing interests.
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فهرسة مساهمة: Keywords: Antibiotic resistance; Ghana; HIV
المشرفين على المادة: 0 (Anti-Bacterial Agents)
تواريخ الأحداث: Date Created: 20170429 Date Completed: 20170608 Latest Revision: 20240529
رمز التحديث: 20240529
مُعرف محوري في PubMed: PMC5398869
DOI: 10.11604/pamj.2017.26.60.10981
PMID: 28451037
قاعدة البيانات: MEDLINE
الوصف
تدمد:1937-8688
DOI:10.11604/pamj.2017.26.60.10981