دورية أكاديمية
أعرض في EDS

Zinc supplementation reduces RANKL/OPG ratio and prevents bone architecture alterations in ovariectomized and type 1 diabetic rats.

التفاصيل البيبلوغرافية
العنوان: Zinc supplementation reduces RANKL/OPG ratio and prevents bone architecture alterations in ovariectomized and type 1 diabetic rats.
المؤلفون: Ferreira ECS; Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil., Bortolin RH; Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil., Freire-Neto FP; Department of Biochemistry, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil., Souza KSC; Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil., Bezerra JF; Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil., Ururahy MAG; Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil., Ramos AMO; Department of Clinical Pathology, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil., Himelfarb ST; School of Pharmaceutical Science, University of São Paulo, São Paulo, Brazil., Abreu BJ; Department of Morphology, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil., Didone TVN; School of Pharmaceutical Science, University of São Paulo, São Paulo, Brazil., Pedrosa LFC; Department of Nutrition, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil., Medeiros AC; Department of Clinical Medicine, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil., Doi SQ; Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA., Brandão-Neto J; Department of Clinical Medicine, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil., Hirata RDC; School of Pharmaceutical Science, University of São Paulo, São Paulo, Brazil., Rezende LA; Department of Chemistry, University of Ribeirão Preto, Ribeirão Preto, São Paulo, Brazil., Almeida MG; Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil., Hirata MH; School of Pharmaceutical Science, University of São Paulo, São Paulo, Brazil., Rezende AA; Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil. Electronic address: adrirezende@yahoo.com.
المصدر: Nutrition research (New York, N.Y.) [Nutr Res] 2017 Apr; Vol. 40, pp. 48-56. Date of Electronic Publication: 2017 Mar 14.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8303331 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0739 (Electronic) Linking ISSN: 02715317 NLM ISO Abbreviation: Nutr Res Subsets: MEDLINE
أسماء مطبوعة: Publication: <2004- > : Tarrytown, NY : Elsevier Science
Original Publication: New York : Pergamon Press, c1981-
مواضيع طبية MeSH: Dietary Supplements*, Bone Density/*drug effects , Diabetes Mellitus, Experimental/*drug therapy , Osteoprotegerin/*metabolism , RANK Ligand/*metabolism , Zinc/*administration & dosage, Alkaline Phosphatase/blood ; Animals ; Blood Glucose/metabolism ; Bone and Bones/drug effects ; Calcium/blood ; Diabetes Mellitus, Type 1/drug therapy ; Female ; Osteoprotegerin/genetics ; Ovariectomy ; Phosphorus/blood ; RANK Ligand/genetics ; Rats ; Rats, Wistar
مستخلص: Type 1 diabetes mellitus (T1DM) and estrogen deficiency are associated with several alterations in bone turnover. Zinc (Zn) is required for growth, development, and overall health. Zinc has been used in complementary therapy against bone loss in several diseases. We hypothesized that Zn supplementation represents a potential therapy against severe bone loss induced by the combined effect of estrogen deficiency and T1DM. We evaluated the protective effect of Zn against bone alterations in a chronic model of these disorders. Female Wistar rats were ramdomized into 3 groups (5 rats each): control, OVX/T1DM (ovariectomized rats with streptozotocin-induced T1DM), and OVX/T1DM+Zn (OVX/T1DM plus daily Zn supplementation). Serum biochemical, bone histomorphometric, and molecular analyses were performed. Histomorphometric parameters were similar between the control and OVX/T1DM+Zn groups, suggesting that Zn prevents bone architecture alterations. In contrast, the OVX/T1DM group showed significantly lower trabecular width and bone area as well as greater trabecular separation than the control. The OVX/T1DM and OVX/T1DM+Zn groups had significantly higher serum alkaline phosphatase activity than the control. The supplemented group had higher levels of serum-ionized calcium and phosphorus than the nonsupplemented group. The RANKL/OPG ratio was similar between the control and OVX/T1DM+Zn groups, whereas it was higher in the OVX/T1DM group. In conclusion, Zn supplementation prevents bone alteration in chronic OVX/T1DM rats, as demonstrated by the reduced RANKL/OPG ratio and preservation of bone architecture. The findings may represent a novel therapeutic approach to preventing OVX/T1DM-induced bone alterations.
(Copyright © 2017 Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: Diabetic rat; Estrogen deficiency; Histomorphometry; RANKL/OPG; Type 1 diabetes mellitus; Zinc
المشرفين على المادة: 0 (Blood Glucose)
0 (Osteoprotegerin)
0 (RANK Ligand)
0 (Tnfrsf11b protein, rat)
27YLU75U4W (Phosphorus)
EC 3.1.3.1 (Alkaline Phosphatase)
J41CSQ7QDS (Zinc)
SY7Q814VUP (Calcium)
تواريخ الأحداث: Date Created: 20170506 Date Completed: 20180306 Latest Revision: 20180306
رمز التحديث: 20231215
DOI: 10.1016/j.nutres.2017.03.004
PMID: 28473060
قاعدة البيانات: MEDLINE
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