دورية أكاديمية
Medication-related osteonecrosis of the jaw: risk factors in patients under biphosphonate versus patients under antiresorptive-antiangiogenic drugs.
| العنوان: | Medication-related osteonecrosis of the jaw: risk factors in patients under biphosphonate versus patients under antiresorptive-antiangiogenic drugs. |
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| المؤلفون: | Ghidini G; Department of Biomedical, Biotechnological and Translational Science, Center of Oral Medicine and Laser Surgery, University of Parma, Parma, Italy - dr.ghidinigiulia@gmail.com., Manfredi M; Department of Biomedical, Biotechnological and Translational Science, Center of Oral Medicine and Laser Surgery, University of Parma, Parma, Italy., Giovannacci I; Department of Biomedical, Biotechnological and Translational Science, Center of Oral Medicine and Laser Surgery, University of Parma, Parma, Italy., Mergoni G; Department of Biomedical, Biotechnological and Translational Science, Center of Oral Medicine and Laser Surgery, University of Parma, Parma, Italy., Sarraj A; Department of Biomedical, Biotechnological and Translational Science, Center of Oral Medicine and Laser Surgery, University of Parma, Parma, Italy., Mureddu M; Department of Biomedical, Biotechnological and Translational Science, Center of Oral Medicine and Laser Surgery, University of Parma, Parma, Italy., Giunta G; Department of Biomedical, Biotechnological and Translational Science, Center of Oral Medicine and Laser Surgery, University of Parma, Parma, Italy., Bonanini M; Department of Biomedical, Biotechnological and Translational Science, Center of Oral Medicine and Laser Surgery, University of Parma, Parma, Italy., Meleti M; Department of Biomedical, Biotechnological and Translational Science, Center of Oral Medicine and Laser Surgery, University of Parma, Parma, Italy., Vescovi P; Department of Biomedical, Biotechnological and Translational Science, Center of Oral Medicine and Laser Surgery, University of Parma, Parma, Italy. |
| المصدر: | Minerva stomatologica [Minerva Stomatol] 2017 Aug; Vol. 66 (4), pp. 135-140. Date of Electronic Publication: 2017 May 10. |
| نوع المنشور: | Comparative Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Edizioni Minerva Medica Country of Publication: Italy NLM ID: 0421071 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1827-174X (Electronic) Linking ISSN: 00264970 NLM ISO Abbreviation: Minerva Stomatol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Torino : Edizioni Minerva Medica |
| مواضيع طبية MeSH: | Angiogenesis Inhibitors/*adverse effects , Bisphosphonate-Associated Osteonecrosis of the Jaw/*epidemiology , Bone Density Conservation Agents/*adverse effects , Diphosphonates/*adverse effects, Aged ; Aged, 80 and over ; Amoxicillin-Potassium Clavulanate Combination/therapeutic use ; Angiogenesis Inhibitors/administration & dosage ; Antibodies, Monoclonal/administration & dosage ; Antibodies, Monoclonal/adverse effects ; Bisphosphonate-Associated Osteonecrosis of the Jaw/drug therapy ; Bisphosphonate-Associated Osteonecrosis of the Jaw/etiology ; Bisphosphonate-Associated Osteonecrosis of the Jaw/surgery ; Bone Density Conservation Agents/administration & dosage ; Bone Neoplasms/drug therapy ; Bone Neoplasms/secondary ; Bone Neoplasms/surgery ; Combined Modality Therapy ; Dental Implants ; Diphosphonates/administration & dosage ; Drug Therapy, Combination ; Female ; Humans ; Laser Therapy ; Lasers, Solid-State ; Male ; Metronidazole/therapeutic use ; Middle Aged ; Osteoporosis/drug therapy ; Postoperative Complications/chemically induced ; Postoperative Complications/epidemiology ; Retrospective Studies ; Risk ; Risk Factors ; Tooth Extraction |
| مستخلص: | Background: Biphosphonate-related osteonecrosis of the jaw (BRONJ) is a potential side effect associated with the administration of bisphosphonates; the aim of this work is to highlight the possible epidemiological differences between two groups of patients affected by medication related osteonecrosis of the jaw (MRONJ) treated at the Center of Oral Medicine, Pathology and Laser Surgery of the Academic Hospital at the University of Parma, Italy, between January 2004 and June 2016. Methods: Medical charts of 303 patients (214 females and 89 males, mean age: 67 years old) treated at the Center of Oral Medicine, Pathology and Laser Surgery of the Academic Hospital at the University of Parma, between January 2004 and June 2016, were retrospectively analyzed. Patients were divided in 2 groups according to drugs therapy they underwent: group 1 (G1) including patients treated with bisphosphonates alone and group 2 (G2) including patients receiving antiresorptive-antiangiogenic drugs in association with bisphosphonates or antiresorptive-antiangiogenic drugs alone. Than 269 MRONJ sites treated with 5 different therapeutical approaches were analyzed. Results: Results showed G1 consisting mainly in female patients undergoing bisphosphonates for oncologic disease, stage II was most frequently diagnosed and MRONJ developed mainly after dental extraction or bone surgery. G2 consisted mainly in males patients, whom took antiresorptive-antiangiogenic drugs in association with bisphosphonate or antiresorptive-antiangiogenic drugs alone for oncologic disease. Stage II was most frequently diagnosed and MRONJ developed most frequently "spontaneous". Conclusions: This study showed how a new population affected by MRONJ is emerging. Men affected by kidney cancer treated with new antiresorptive-antiangiogenic drugs will represent a growing portion of the pool of patients at risk. In our experience, a strict follow-up is of outmost importance to early detect MRONJ also in patients with spontaneous cases. When MRONJ occurs, surgical laser treatment with Er:YAG seems to represent the option with highest percentage of success; for patients with contraindication to surgery, LLLT helps to improve outcomes of the medical therapy. |
| المشرفين على المادة: | 0 (Angiogenesis Inhibitors) 0 (Antibodies, Monoclonal) 0 (Bone Density Conservation Agents) 0 (Dental Implants) 0 (Diphosphonates) 140QMO216E (Metronidazole) 74469-00-4 (Amoxicillin-Potassium Clavulanate Combination) |
| تواريخ الأحداث: | Date Created: 20170513 Date Completed: 20180530 Latest Revision: 20220321 |
| رمز التحديث: | 20231215 |
| DOI: | 10.23736/S0026-4970.17.04056-0 |
| PMID: | 28497661 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1827-174X |
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| DOI: | 10.23736/S0026-4970.17.04056-0 |