Significantly higher rates of multiple and proximally located adenomas among patients with diabetes mellitus: A cross-sectional population-based study.

التفاصيل البيبلوغرافية
العنوان:	Significantly higher rates of multiple and proximally located adenomas among patients with diabetes mellitus: A cross-sectional population-based study.
المؤلفون:	de Kort S; Division of Gastroenterology and Hepatology, Maastricht University Medical Center, Maastricht, the Netherlands., Bouwens MW; Division of Gastroenterology and Hepatology, Maastricht University Medical Center, Maastricht, the Netherlands., Weijenberg MP; Department of Epidemiology, Maastricht University, Maastricht, the Netherlands., Janssen-Heijnen ML; Department of Epidemiology, Maastricht University, Maastricht, the Netherlands.; Department of Clinical Epidemiology, VieCuri Medical Center, Venlo, the Netherlands., de Bruïne AP; Department of Pathology, Viecuri Medical Center, Venlo, the Netherlands., Riedl R; Department of Pathology, Maastricht University Medical Center, Maastricht, the Netherlands., Masclee AA; Division of Gastroenterology and Hepatology, Maastricht University Medical Center, Maastricht, the Netherlands., Sanduleanu S; Division of Gastroenterology and Hepatology, Maastricht University Medical Center, Maastricht, the Netherlands.
المصدر:	United European gastroenterology journal [United European Gastroenterol J] 2017 Apr; Vol. 5 (3), pp. 415-423. Date of Electronic Publication: 2016 Aug 09.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Wiley Country of Publication: England NLM ID: 101606807 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2050-6406 (Print) Linking ISSN: 20506406 NLM ISO Abbreviation: United European Gastroenterol J Subsets: PubMed not MEDLINE
أسماء مطبوعة:	Publication: 2021- : [London] : Wiley Original Publication: London : Sage Publications, [2013]-
مستخلص:	Background: Diabetes mellitus (DM) is associated with a greater risk for colorectal cancer (CRC). Objective: The objective of this article is to examine the endoscopic phenotype and histopathology of colorectal polyps in patients with vs without DM. Methods: We conducted a cross-sectional study of patients who underwent colonoscopy at our university hospital and who completed a questionnaire. We collected endoscopy and histopathology data regarding colorectal adenomas and serrated polyps. Cox regression analyses were used to estimate adjusted prevalence ratios (PRs). Results: We examined a total of 3654 patients (mean age (SD): 62 (12) years, 47% males). Of them, 360 (9.9%) had DM. Overall, the prevalence of colorectal adenomas (42% vs 32%, p < 0.01), multiple (≥3) adenomas (12% vs 7%, p = 0.01) and proximal adenomas (30% vs 19%, p < 0.01) was higher in patients with vs without DM. Multivariable analysis showed that the prevalence of adenomas (PR 1.17, 95% CI; 1.02-1.34), multiple (PR 1.37, 95% CI; 1.00-1.86) and proximal (PR 1.37, 95% CI; 1.16-1.62) adenomas was higher in patients with vs without DM, especially in men. Conclusion: Patients with DM harbor more frequently multiple and proximal adenomas than those without DM. Close colonoscopic surveillance of DM patients is important to maximize the effectiveness of colonoscopic CRC prevention.
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فهرسة مساهمة:	Keywords: Diabetes mellitus; colonoscopy; colorectal cancer; colorectal neoplasm; epidemiology; prevention
تواريخ الأحداث:	Date Created: 20170517 Latest Revision: 20191120
رمز التحديث:	20231215
مُعرف محوري في PubMed:	PMC5415214
DOI:	10.1177/2050640616664271
PMID:	28507754
قاعدة البيانات:	MEDLINE

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تدمد:	2050-6406
DOI:	10.1177/2050640616664271