دورية أكاديمية
Coconut (Cocos nucifera) Ethanolic Leaf Extract Reduces Amyloid-β (1-42) Aggregation and Paralysis Prevalence in Transgenic Caenorhabditis elegans Independently of Free Radical Scavenging and Acetylcholinesterase Inhibition.
العنوان: | Coconut (Cocos nucifera) Ethanolic Leaf Extract Reduces Amyloid-β (1-42) Aggregation and Paralysis Prevalence in Transgenic Caenorhabditis elegans Independently of Free Radical Scavenging and Acetylcholinesterase Inhibition. |
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المؤلفون: | Manalo RV; Department of Biochemistry and Molecular Biology, College of Medicine, University of the Philippines Manila, Ermita, Manila 1000, Philippines. rmmanalo3@up.edu.ph., Silvestre MA; Juan R. Liwag Memorial High School, Gapan, Nueva Ecija 3105, Philippines. mariesannrs@yahoo.com., Barbosa ALA; Juan R. Liwag Memorial High School, Gapan, Nueva Ecija 3105, Philippines. barbosa.azaleaanne@yahoo.com., Medina PM; Department of Biochemistry and Molecular Biology, College of Medicine, University of the Philippines Manila, Ermita, Manila 1000, Philippines. pmbmedina@post.upm.edu.ph. |
المصدر: | Biomedicines [Biomedicines] 2017 Apr 21; Vol. 5 (2). Date of Electronic Publication: 2017 Apr 21. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101691304 Publication Model: Electronic Cited Medium: Print ISSN: 2227-9059 (Print) Linking ISSN: 22279059 NLM ISO Abbreviation: Biomedicines Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI AG, [2013]- |
مستخلص: | Virgin coconut oil (VCO) has been the subject of several studies which have aimed to alleviate Alzheimer's disease (AD) pathology, focusing on in vitro antioxidant and acetylcholinesterase (AChE) inhibitory activities. Here, we studied an underutilized and lesser-valued part of the coconut tree, specifically the leaves, using in vitro and in vivo approaches. Coconut leaf extract (CLE) was screened for antioxidant and AChE inhibitory properties in vitro and therapeutic effects in two strains of transgenic Caenorhabditis elegans expressing amyloid-β |
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معلومات مُعتمدة: | P40 OD010440 United States OD NIH HHS |
فهرسة مساهمة: | Keywords: Alzheimer’s disease (AD); Caenorhabditis elegans; Cocos nucifera; coconut leaf extract; sporadic inclusion body myositis (sIBM) |
تواريخ الأحداث: | Date Created: 20170525 Latest Revision: 20200930 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC5489803 |
DOI: | 10.3390/biomedicines5020017 |
PMID: | 28536360 |
قاعدة البيانات: | MEDLINE |
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