دورية أكاديمية
أعرض في EDS

Saccharomyces cerevisiae-derived virus-like particle parvovirus B19 vaccine elicits binding and neutralizing antibodies in a mouse model for sickle cell disease.

التفاصيل البيبلوغرافية
العنوان: Saccharomyces cerevisiae-derived virus-like particle parvovirus B19 vaccine elicits binding and neutralizing antibodies in a mouse model for sickle cell disease.
المؤلفون: Penkert RR; Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN, United States., Young NS; Hematology Branch, National Heart, Lung and Blood Institute, Bethesda, MD, United States., Surman SL; Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN, United States., Sealy RE; Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN, United States., Rosch J; Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN, United States; Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, TN, United States., Dormitzer PR; Novartis Vaccines and Diagnostics, Cambridge, MA, United States., Settembre EC; Novartis Vaccines and Diagnostics, Cambridge, MA, United States., Chandramouli S; GSK Vaccines, Rockville, MD, United States., Wong S; Hematology Branch, National Heart, Lung and Blood Institute, Bethesda, MD, United States., Hankins JS; Department of Hematology, St Jude Children's Research Hospital, Memphis, TN, United States., Hurwitz JL; Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN, United States; Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, TN, United States. Electronic address: julia.hurwitz@stjude.org.
المصدر: Vaccine [Vaccine] 2017 Jun 22; Vol. 35 (29), pp. 3615-3620. Date of Electronic Publication: 2017 May 26.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8406899 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2518 (Electronic) Linking ISSN: 0264410X NLM ISO Abbreviation: Vaccine Subsets: MEDLINE
أسماء مطبوعة: Publication: Amsterdam, The Netherlands : Elsevier Science
Original Publication: [Guildford, Surrey, UK] : Butterworths, [c1983-
مواضيع طبية MeSH: Anemia, Sickle Cell/*complications , Antibodies, Neutralizing/*blood , Antibodies, Viral/*blood , Erythema Infectiosum/*prevention & control , Parvovirus B19, Human/*immunology , Vaccines, Virus-Like Particle/*immunology, Adjuvants, Immunologic/administration & dosage ; Animals ; Disease Models, Animal ; Mice ; Parvovirus B19, Human/genetics ; Polysorbates/administration & dosage ; Respirovirus Infections/prevention & control ; Saccharomyces cerevisiae/genetics ; Squalene/administration & dosage ; Vaccines, Synthetic/administration & dosage ; Vaccines, Synthetic/genetics ; Vaccines, Synthetic/immunology ; Vaccines, Synthetic/isolation & purification ; Vaccines, Virus-Like Particle/administration & dosage ; Vaccines, Virus-Like Particle/genetics ; Vaccines, Virus-Like Particle/isolation & purification
مستخلص: Parvovirus B19 infections are typically mild in healthy individuals, but can be life threatening in individuals with sickle cell disease (SCD). A Saccharomyces cerevisiae-derived B19 VLP vaccine, now in pre-clinical development, is immunogenic in wild type mice when administered with the adjuvant MF59. Because SCD alters the immune response, we evaluated the efficacy of this vaccine in a mouse model for SCD. Vaccinated mice with SCD demonstrated similar binding and neutralizing antibody responses to those of heterozygous littermate controls following a prime-boost-boost regimen. Due to the lack of a mouse parvovirus B19 challenge model, we employed a natural mouse pathogen, Sendai virus, to evaluate SCD respiratory tract responses to infection. Normal mucosal and systemic antibody responses were observed in these mice. Results demonstrate that mice with SCD can respond to a VLP vaccine and to a respiratory virus challenge, encouraging rapid development of the B19 vaccine for patients with SCD.
(Copyright © 2017 Elsevier Ltd. All rights reserved.)
References: Am J Dis Child. 1984 Apr;138(4):401-3. (PMID: 6322575)
Adv Pediatr Infect Dis. 1999;14:191-218. (PMID: 10079855)
Am J Pathol. 2012 Nov;181(5):1725-34. (PMID: 23000264)
Exp Biol Med (Maywood). 2016 Apr;241(7):749-54. (PMID: 26940953)
Pediatrics. 2014 Oct;134(4):686-95. (PMID: 25180279)
Am J Dis Child. 1992 Nov;146(11):1328-30. (PMID: 1415073)
Vaccine. 2013 Aug 20;31(37):3872-8. (PMID: 23827313)
Virology. 2011 Feb 20;410(2):429-436. (PMID: 21227475)
Immunology. 2003 Apr;108(4):431-9. (PMID: 12667204)
J Pediatr. 2012 Jan;160(1):74-81. (PMID: 21840537)
Br J Haematol. 2003 Oct;123(2):359-65. (PMID: 14531921)
J Virol. 2008 Mar;82(5):2470-6. (PMID: 18160440)
Transl Res. 2015 Sep;166(3):254-68. (PMID: 25843670)
J Infect Dis. 2003 Feb 15;187(4):675-8. (PMID: 12599085)
Clin Vaccine Immunol. 2014 Apr;21(4):598-601. (PMID: 24554696)
Blood. 2004 Jan 15;103(2):422-7. (PMID: 14525777)
Science. 1997 Oct 31;278(5339):876-8. (PMID: 9346488)
Vaccine. 2011 Oct 6;29(43):7357-63. (PMID: 21807052)
J Clin Invest. 2010 Feb;120(2):627-35. (PMID: 20093777)
معلومات مُعتمدة: P30 CA021765 United States CA NCI NIH HHS; R01 AI110618 United States AI NIAID NIH HHS
فهرسة مساهمة: Keywords: Intramuscular; Mucosal antibody response; Parvovirus B19 vaccine; Sickle cell disease; Systemic antibody; Yeast-derived
المشرفين على المادة: 0 (Adjuvants, Immunologic)
0 (Antibodies, Neutralizing)
0 (Antibodies, Viral)
0 (MF59 oil emulsion)
0 (Polysorbates)
0 (Vaccines, Synthetic)
0 (Vaccines, Virus-Like Particle)
7QWM220FJH (Squalene)
تواريخ الأحداث: Date Created: 20170531 Date Completed: 20180220 Latest Revision: 20201209
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC5526597
DOI: 10.1016/j.vaccine.2017.05.022
PMID: 28554503
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-2518
DOI:10.1016/j.vaccine.2017.05.022