دورية أكاديمية
Biotransformed citrus extract as a source of anti-inflammatory polyphenols: Effects in macrophages and adipocytes.
| العنوان: | Biotransformed citrus extract as a source of anti-inflammatory polyphenols: Effects in macrophages and adipocytes. |
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| المؤلفون: | Nakajima VM; Department of Food and Nutrition, Faculty of Food Engineering, State University of Campinas - UNICAMP, Rua Monteiro Lobato, 80, Cidade Universitária Zeferino Vaz, CP 6121, CEP 13083-862 Campinas, SP, Brazil. Electronic address: vania_nakajima@yahoo.com.br., Moala T; Department of Food and Nutrition, Faculty of Food Engineering, State University of Campinas - UNICAMP, Rua Monteiro Lobato, 80, Cidade Universitária Zeferino Vaz, CP 6121, CEP 13083-862 Campinas, SP, Brazil., Caria CREP; Clinical Pharmacology and Gastroenterology Unit, São Francisco University Medical School, Bragança Paulista, SP, Brazil., Moura CS; Department of Food and Nutrition, Faculty of Food Engineering, State University of Campinas - UNICAMP, Rua Monteiro Lobato, 80, Cidade Universitária Zeferino Vaz, CP 6121, CEP 13083-862 Campinas, SP, Brazil., Amaya-Farfan J; Department of Food and Nutrition, Faculty of Food Engineering, State University of Campinas - UNICAMP, Rua Monteiro Lobato, 80, Cidade Universitária Zeferino Vaz, CP 6121, CEP 13083-862 Campinas, SP, Brazil., Gambero A; Clinical Pharmacology and Gastroenterology Unit, São Francisco University Medical School, Bragança Paulista, SP, Brazil., Macedo GA; Department of Food and Nutrition, Faculty of Food Engineering, State University of Campinas - UNICAMP, Rua Monteiro Lobato, 80, Cidade Universitária Zeferino Vaz, CP 6121, CEP 13083-862 Campinas, SP, Brazil., Macedo JA; Department of Food and Nutrition, Faculty of Food Engineering, State University of Campinas - UNICAMP, Rua Monteiro Lobato, 80, Cidade Universitária Zeferino Vaz, CP 6121, CEP 13083-862 Campinas, SP, Brazil. |
| المصدر: | Food research international (Ottawa, Ont.) [Food Res Int] 2017 Jul; Vol. 97, pp. 37-44. Date of Electronic Publication: 2017 Mar 22. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Published on behalf of the Canadian Institute of Food Science and Technology by Elsevier Applied Science Country of Publication: Canada NLM ID: 9210143 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7145 (Electronic) Linking ISSN: 09639969 NLM ISO Abbreviation: Food Res Int Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Ottawa, Ontario, Canada : Published on behalf of the Canadian Institute of Food Science and Technology by Elsevier Applied Science, c1992- |
| مواضيع طبية MeSH: | Adipocytes/*drug effects , Anti-Inflammatory Agents/*metabolism , Citrus/*chemistry , Macrophages/*drug effects , Plant Extracts/*pharmacology , Polyphenols/*pharmacology, 3T3-L1 Cells ; Animals ; Anti-Inflammatory Agents/analysis ; Anti-Inflammatory Agents/pharmacology ; Biotransformation ; Cell Survival/drug effects ; Cytokines/analysis ; Cytokines/metabolism ; Fermentation ; Mice ; Plant Extracts/metabolism ; Polyphenols/metabolism ; RAW 264.7 Cells |
| مستخلص: | Chronic non-communicable diseases such as obesity are preceded by increased macrophage infiltration in adipose tissue and greater secretion of pro-inflammatory cytokines. We evaluated the anti-inflammatory potential of Biotransformed extract, and two control extracts: In Natura and Autoclaved. The assays were performed using a cellular model with RAW264.7, 3T3-L1 cells, and RAW264.7 and 3T3-L1 co-culture. The innovation of the study was the use of Biotransformed extract, a unique phenolic extract of a bioprocessed citrus residue. LPS stimulated RAW264.7 cells treated with the Biotransformed extract exhibited lower secretion of TNF-α and NO and lower protein expression of NFκB. In RAW264.7 and 3T3-L1 co-culture, treatment with 1.0mg/mL of the Biotransformed extract reduced secretion of TNF-α (30.7%) and IL-6 (43.4%). Still, the Biotransformed extract caused higher increase in adiponectin in relation to control extracts. When the co-culture received a LPS stimulus, the Autoclaved extract at 1.0mg/mL reduced IL-6 and TNF-α concentrations, and raised adiponectin. However, it was noteworthy that the Biotransformed extract was also able to significantly reduce IL-6 concentration while the Natural extract was not. The Biotransformed citrus extract evaluated in this study showed anti-inflammatory activity in macrophages and in co-culture, indicating that bioprocess of citrus residue can contribute to new product development with anti-inflammatory potential. (Copyright © 2017 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Anti-inflammatory activity; Cell culture; Citrus residue extract; Hesperidin (PubChem CID: 3594); Hesperitin (PubChem CID: 72281); Naringenin (PubChem CID: 932); Naringin (PubChem CID: 74787988); Obesity; Polyphenols |
| المشرفين على المادة: | 0 (Anti-Inflammatory Agents) 0 (Cytokines) 0 (Plant Extracts) 0 (Polyphenols) |
| تواريخ الأحداث: | Date Created: 20170605 Date Completed: 20190506 Latest Revision: 20190506 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.foodres.2017.03.034 |
| PMID: | 28578062 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-7145 |
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| DOI: | 10.1016/j.foodres.2017.03.034 |