دورية أكاديمية
أعرض في EDS

Pyrin-only protein 2 limits inflammation but improves protection against bacteria.

التفاصيل البيبلوغرافية
العنوان: Pyrin-only protein 2 limits inflammation but improves protection against bacteria.
المؤلفون: Periasamy S; Department of Immunology and Microbial Disease, Albany Medical College, Albany, New York 12208 USA., Porter KA; Department of Immunology and Microbial Disease, Albany Medical College, Albany, New York 12208 USA., Atianand MK; Department of Immunology and Microbial Disease, Albany Medical College, Albany, New York 12208 USA., T Le H; Department of Immunology and Microbial Disease, Albany Medical College, Albany, New York 12208 USA.; Department of Biochemistry, University of Science, Vietnam National University, Ward 4, District 5, Ho Chi Minh City 749000, Vietnam., Earley S; Department of Immunology and Microbial Disease, Albany Medical College, Albany, New York 12208 USA., Duffy EB; Department of Immunology and Microbial Disease, Albany Medical College, Albany, New York 12208 USA., Haller MC; Department of Immunology and Microbial Disease, Albany Medical College, Albany, New York 12208 USA., Chin H; Department of Immunology and Microbial Disease, Albany Medical College, Albany, New York 12208 USA., Harton JA; Department of Immunology and Microbial Disease, Albany Medical College, Albany, New York 12208 USA.
المصدر: Nature communications [Nat Commun] 2017 Jun 05; Vol. 8, pp. 15564. Date of Electronic Publication: 2017 Jun 05.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : Nature Pub. Group
مواضيع طبية MeSH: Francisella/*immunology , Gram-Negative Bacterial Infections/*immunology , Gram-Negative Bacterial Infections/*prevention & control , Inflammation/*immunology , Tularemia/*immunology , Tularemia/*prevention & control, Animals ; Cell Line ; Female ; HEK293 Cells ; HeLa Cells ; Humans ; Inflammasomes/immunology ; Interferon-gamma/biosynthesis ; Interferon-gamma/immunology ; Listeria monocytogenes/immunology ; Macrophages/immunology ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Transgenic ; NLR Family, Pyrin Domain-Containing 3 Protein/biosynthesis ; Neutrophils/immunology ; Promoter Regions, Genetic/genetics ; Salmonella typhimurium/immunology ; Transcription Factor RelA/biosynthesis ; Tularemia/microbiology ; U937 Cells
مستخلص: Pyrin domain-only proteins (POPs) are recently evolved, primate-specific proteins demonstrated in vitro as negative regulators of inflammatory responses. However, their in vivo function is not understood. Of the four known POPs, only POP2 is reported to regulate NF-κB-dependent transcription and multiple inflammasomes. Here we use a transgenic mouse-expressing POP2 controlled by its endogenous human promotor to study the immunological functions of POP2. Despite having significantly reduced inflammatory cytokine responses to LPS and bacterial infection, POP2 transgenic mice are more resistant to bacterial infection than wild-type mice. In a pulmonary tularaemia model, POP2 enhances IFN-γ production, modulates neutrophil numbers, improves macrophage functions, increases bacterial control and diminishes lung pathology. Thus, unlike other POPs thought to diminish innate protection, POP2 reduces detrimental inflammation while preserving and enhancing protective immunity. Our findings suggest that POP2 acts as a high-order regulator balancing cellular function and inflammation with broad implications for inflammation-associated diseases and therapeutic intervention.
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معلومات مُعتمدة: P01 AI056320 United States AI NIAID NIH HHS; R01 AI072259 United States AI NIAID NIH HHS
المشرفين على المادة: 0 (Inflammasomes)
0 (NLR Family, Pyrin Domain-Containing 3 Protein)
0 (NLRP3 protein, human)
0 (RELA protein, human)
0 (Transcription Factor RelA)
82115-62-6 (Interferon-gamma)
تواريخ الأحداث: Date Created: 20170606 Date Completed: 20181119 Latest Revision: 20181119
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC5512670
DOI: 10.1038/ncomms15564
PMID: 28580947
قاعدة البيانات: MEDLINE
الوصف
تدمد:2041-1723
DOI:10.1038/ncomms15564