دورية أكاديمية
Effect of pre-emptive analgesia on clinical parameters and tissue levels of TNF-α and IL-1β in third molar surgery: a triple-blind, randomized, placebo-controlled study.
| العنوان: | Effect of pre-emptive analgesia on clinical parameters and tissue levels of TNF-α and IL-1β in third molar surgery: a triple-blind, randomized, placebo-controlled study. |
|---|---|
| المؤلفون: | Albuquerque AFM; Post-graduate Program in Dentistry, School of Dentistry, Federal University of Ceará, Ceará, Fortaleza, Brazil; Division of Oral Surgery, School of Dentistry, Fortaleza University (UNIFOR), Ceará, Fortaleza, Brazil., Fonteles CSR; Post-graduate Program in Dentistry, School of Dentistry, Federal University of Ceará, Ceará, Fortaleza, Brazil., do Val DR; Renorbio Post-graduate Program, Federal University of Pernambuco, Recife, Pernambuco, Brazil., Chaves HV; Post-graduate Program in Health Science, Medical School, Federal University of Ceará, Sobral, Ceará, Brazil., Bezerra MM; Post-graduate Program in Health Science, Medical School, Federal University of Ceará, Sobral, Ceará, Brazil., Pereira KMA; Post-graduate Program in Dentistry, School of Dentistry, Federal University of Ceará, Ceará, Fortaleza, Brazil., de Barros Silva PG; Division of Oral Surgery, School of Dentistry, Fortaleza University (UNIFOR), Ceará, Fortaleza, Brazil., de Lima BB; Division of Oral Surgery, Walter Cantídio University Hospital, Ceará, Fortaleza, Brazil., Soares ECS; Post-graduate Program in Dentistry, School of Dentistry, Federal University of Ceará, Ceará, Fortaleza, Brazil., Ribeiro TR; Post-graduate Program in Dentistry, School of Dentistry, Federal University of Ceará, Ceará, Fortaleza, Brazil., Costa FWG; Post-graduate Program in Dentistry, School of Dentistry, Federal University of Ceará, Ceará, Fortaleza, Brazil. Electronic address: fwildson@yahoo.com.br. |
| المصدر: | International journal of oral and maxillofacial surgery [Int J Oral Maxillofac Surg] 2017 Dec; Vol. 46 (12), pp. 1615-1625. Date of Electronic Publication: 2017 Jun 10. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial |
| اللغة: | English |
| بيانات الدورية: | Publisher: Churchill Livingstone Country of Publication: Denmark NLM ID: 8605826 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1399-0020 (Electronic) Linking ISSN: 09015027 NLM ISO Abbreviation: Int J Oral Maxillofac Surg Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Copenhagen : Churchill Livingstone Original Publication: Copenhagen : Munksgaard, c1986- |
| مواضيع طبية MeSH: | Tooth Extraction*, Analgesia/*methods , Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use , Cyclooxygenase 2 Inhibitors/*therapeutic use , Ibuprofen/*therapeutic use , Interleukin-1beta/*metabolism , Molar, Third/*surgery , Pain Management/*methods , Pain, Postoperative/*prevention & control , Pyridines/*therapeutic use , Sulfones/*therapeutic use , Tumor Necrosis Factor-alpha/*metabolism, Adolescent ; Adult ; Cross-Over Studies ; Etoricoxib ; Female ; Humans ; Male ; Pain Measurement ; Placebos ; Treatment Outcome |
| مستخلص: | This study aimed to evaluate whether pre-emptive analgesia modifies the tissue expression of tumour necrosis factor alpha (TNF-α) and interleukin 1 beta (IL-1β), and whether there is an association with postoperative surgical outcomes. A triple-blind, randomized, placebo-controlled study of patients undergoing mandibular third molar removal was performed. Volunteers were allocated randomly to receive etoricoxib 120 mg, ibuprofen 400 mg, or placebo 1h before surgery. Twenty-four surgical sites per group were required (95% confidence level and 80% statistical power). Pain scores differed significantly between groups (P<0.001). Etoricoxib and ibuprofen reduced pain scores compared to placebo (P<0.05). Pain scores peaked at 4h postoperative in the experimental groups, but at 2h postoperative in the placebo group (P<0.05). A significant reduction in TNF-α concentration from time 0' to time 30' was seen for ibuprofen (P=0.001) and etoricoxib (P=0.016). The ibuprofen group showed a significant reduction in IL-1β levels from time 0' to time 30' (P=0.038). In conclusion, TNF-α and IL-1β levels and the inflammatory events in third molar surgery were inversely associated with the degree of cyclooxygenase 2 selectivity of the non-steroidal anti-inflammatory drugs used pre-emptively. Patients given pre-emptive analgesia showed significant reductions in the clinical parameters pain, trismus, and oedema when compared to the placebo group. (Copyright © 2017 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: IL-1β; TNF-α; inflammatory events; non-steroidal anti-inflammatory drugs; third molar |
| المشرفين على المادة: | 0 (Anti-Inflammatory Agents, Non-Steroidal) 0 (Cyclooxygenase 2 Inhibitors) 0 (Interleukin-1beta) 0 (Placebos) 0 (Pyridines) 0 (Sulfones) 0 (Tumor Necrosis Factor-alpha) WK2XYI10QM (Ibuprofen) WRX4NFY03R (Etoricoxib) |
| تواريخ الأحداث: | Date Created: 20170615 Date Completed: 20180731 Latest Revision: 20181202 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.ijom.2017.05.007 |
| PMID: | 28610818 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1399-0020 |
|---|---|
| DOI: | 10.1016/j.ijom.2017.05.007 |