دورية أكاديمية
Structure and Function of Viral Deubiquitinating Enzymes.
| العنوان: | Structure and Function of Viral Deubiquitinating Enzymes. |
|---|---|
| المؤلفون: | Bailey-Elkin BA; Department of Microbiology, University of Manitoba, Winnipeg, Manitoba R3T2N2, Canada., Knaap RCM; Department of Medical Microbiology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands., Kikkert M; Department of Medical Microbiology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands., Mark BL; Department of Microbiology, University of Manitoba, Winnipeg, Manitoba R3T2N2, Canada. Electronic address: brian.mark@umanitoba.ca. |
| المصدر: | Journal of molecular biology [J Mol Biol] 2017 Nov 10; Vol. 429 (22), pp. 3441-3470. Date of Electronic Publication: 2017 Jun 16. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2985088R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1089-8638 (Electronic) Linking ISSN: 00222836 NLM ISO Abbreviation: J Mol Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Elsevier Original Publication: 1959- : London : Academic Press |
| مواضيع طبية MeSH: | Deubiquitinating Enzymes/*chemistry , Deubiquitinating Enzymes/*metabolism , Viral Proteins/*chemistry , Viral Proteins/*metabolism , Viruses/*enzymology, Host-Pathogen Interactions ; Immune Evasion ; Immunity, Innate ; Viruses/immunology |
| مستخلص: | Post-translational modification of cellular proteins by ubiquitin regulates numerous cellular processes, including innate and adaptive immune responses. Ubiquitin-mediated control over these processes can be reversed by cellular deubiquitinating enzymes (DUBs), which remove ubiquitin from cellular targets and depolymerize polyubiquitin chains. The importance of protein ubiquitination to host immunity has been underscored by the discovery of viruses that encode proteases with deubiquitinating activity, many of which have been demonstrated to actively corrupt cellular ubiquitin-dependent processes to suppress innate antiviral responses and promote viral replication. DUBs have now been identified in diverse viral lineages, and their characterization is providing valuable insights into virus biology and the role of the ubiquitin system in host antiviral mechanisms. Here, we provide an overview of the structural biology of these fascinating viral enzymes and their role innate immune evasion and viral replication. (Copyright © 2017 Elsevier Ltd. All rights reserved.) |
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| فهرسة مساهمة: | Keywords: innate immune evasion; papain-like protease; ubiquitin; viral deubiquitinating enzyme; viruses |
| المشرفين على المادة: | 0 (Viral Proteins) EC 3.4.19.12 (Deubiquitinating Enzymes) |
| تواريخ الأحداث: | Date Created: 20170620 Date Completed: 20171113 Latest Revision: 20231113 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC7094624 |
| DOI: | 10.1016/j.jmb.2017.06.010 |
| PMID: | 28625850 |
| قاعدة البيانات: | MEDLINE |
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