دورية أكاديمية
Maternal HIV infection is an important health determinant in non-HIV-infected infants.
| العنوان: | Maternal HIV infection is an important health determinant in non-HIV-infected infants. |
|---|---|
| المؤلفون: | Rupérez M; aISGlobal, Barcelona Ctr. Int. Health Res. (CRESIB), Hospital Clínic-Universitat de Barcelona, Barcelona, Spain bManhiça Health Research Center (CISM), Manhiça, Mozambique cConsorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain., González R, Maculuve S, Quintó L, López-Varela E, Augusto O, Vala A, Nhacolo A, Sevene E, Naniche D, Menéndez C |
| المصدر: | AIDS (London, England) [AIDS] 2017 Jul 17; Vol. 31 (11), pp. 1545-1553. |
| نوع المنشور: | Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: England NLM ID: 8710219 Publication Model: Print Cited Medium: Internet ISSN: 1473-5571 (Electronic) Linking ISSN: 02699370 NLM ISO Abbreviation: AIDS Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 1998- : London, England : Lippincott Williams & Wilkins Original Publication: London : Gower Academic Journals, c1987- |
| مواضيع طبية MeSH: | Maternal-Child Health Services* , Mothers*, Breast Feeding/*statistics & numerical data , HIV Infections/*transmission , Infectious Disease Transmission, Vertical/*prevention & control, Adult ; Female ; Guidelines as Topic ; HIV Infections/drug therapy ; HIV Infections/mortality ; Health Knowledge, Attitudes, Practice ; Hospitalization/statistics & numerical data ; Humans ; Incidence ; Infant ; Infant Nutrition Disorders/mortality ; Infant Nutritional Physiological Phenomena ; Infant, Newborn ; Longitudinal Studies ; Male ; Mozambique ; Pregnancy |
| مستخلص: | Objective: To assess morbidity and mortality in HIV-exposed uninfected (HEU) children to help guiding appropriate clinical care and effective preventive interventions. Design: This is a longitudinal study comparing two cohorts of children; one born to HIV-infected women and the other born to HIV-uninfected women. Methods: We have analyzed prospectively obtained information on nutritional status, morbidity and mortality from 966 HEU and 909 HIV-unexposed infants followed up until their first 18 months of life at a referral health facility in southern Mozambique. Determinants for adverse health outcomes in HEU children were also assessed using multivariate logistic regression. Results: Increased incidence of hospital admissions (P = 0.0015), shorter survival in the first 18 months of life (P = 0.0510) and moderate and severe malnutrition (P = 0.0006 and 0.0014, respectively) were observed among HEU children compared with HIV-unexposed children. Incidence of outpatient attendance in HEU children was associated with being men, older age and the mother being on antiretroviral treatment. Among HEU children, those who were never breastfed, or who were weaned or were partially breastfed, had an increased incidence of hospital admissions compared with children who were exclusively breastfed. Conclusion: Maternal HIV infection has important health consequences in non-HIV-infected children. As the prevalence of HIV-infected pregnant women is maintained and the proportion of HIV-infected children declines because of the scale-up of antiretroviral treatment during pregnancy and breastfeeding, more focus should be given to the health needs of HEU children to ensure that the post-2015 sustainable development goals are met. |
| معلومات مُعتمدة: | U01 AI069924 United States AI NIAID NIH HHS |
| تواريخ الأحداث: | Date Created: 20170629 Date Completed: 20180202 Latest Revision: 20220409 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1097/QAD.0000000000001499 |
| PMID: | 28657963 |
| قاعدة البيانات: | MEDLINE |
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