دورية أكاديمية
N-myc regulates growth and fiber cell differentiation in lens development.
| العنوان: | N-myc regulates growth and fiber cell differentiation in lens development. |
|---|---|
| المؤلفون: | Cavalheiro GR; Programa de Biologia Celular e do Desenvolvimento, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil., Matos-Rodrigues GE; Programa de Biologia Celular e do Desenvolvimento, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil., Zhao Y; Department of Genetics, Albert Einstein College of Medicine, Bronx, NY, USA., Gomes AL; Programa de Biologia Celular e do Desenvolvimento, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil., Anand D; Department of Biological Sciences, University of Delaware, Newark, DE, USA., Predes D; Programa de Biologia Celular e do Desenvolvimento, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil., de Lima S; Programa de Biologia Celular e do Desenvolvimento, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil., Abreu JG; Programa de Biologia Celular e do Desenvolvimento, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil., Zheng D; Department of Genetics, Albert Einstein College of Medicine, Bronx, NY, USA; Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA; Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, USA., Lachke SA; Department of Biological Sciences, University of Delaware, Newark, DE, USA; Center for Bioinformatics and Computational Biology, University of Delaware, Newark, DE, USA., Cvekl A; Department of Genetics, Albert Einstein College of Medicine, Bronx, NY, USA; Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, NY, USA., Martins RAP; Programa de Biologia Celular e do Desenvolvimento, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil. Electronic address: rodrigo.martins@icb.ufrj.br. |
| المصدر: | Developmental biology [Dev Biol] 2017 Sep 01; Vol. 429 (1), pp. 105-117. Date of Electronic Publication: 2017 Jul 14. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 0372762 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-564X (Electronic) Linking ISSN: 00121606 NLM ISO Abbreviation: Dev Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: San Diego, CA : Elsevier Original Publication: New York. |
| مواضيع طبية MeSH: | Cell Differentiation*/genetics, Lens, Crystalline/*cytology , Lens, Crystalline/*growth & development , N-Myc Proto-Oncogene Protein/*metabolism, Animals ; Cell Nucleus/metabolism ; Cell Proliferation/genetics ; Cell Survival/genetics ; Embryonic Development/genetics ; Gene Expression Regulation, Developmental ; Lens, Crystalline/metabolism ; Mice ; Proto-Oncogene Proteins c-myc/metabolism ; Transcription, Genetic ; Transcriptome/genetics |
| مستخلص: | Myc proto-oncogenes regulate diverse cellular processes during development, but their roles during morphogenesis of specific tissues are not fully understood. We found that c-myc regulates cell proliferation in mouse lens development and previous genome-wide studies suggested functional roles for N-myc in developing lens. Here, we examined the role of N-myc in mouse lens development. Genetic inactivation of N-myc in the surface ectoderm or lens vesicle impaired eye and lens growth, while "late" inactivation in lens fibers had no effect. Unexpectedly, defective growth of N-myc-deficient lenses was not associated with alterations in lens progenitor cell proliferation or survival. Notably, N-myc-deficient lens exhibited a delay in degradation of DNA in terminally differentiating lens fiber cells. RNA-sequencing analysis of N-myc-deficient lenses identified a cohort of down-regulated genes associated with fiber cell differentiation that included DNaseIIβ. Further, an integrated analysis of differentially expressed genes in N-myc-deficient lens using normal lens expression patterns of iSyTE, N-myc-binding motif analysis and molecular interaction data from the String database led to the derivation of an N-myc-based gene regulatory network in the lens. Finally, analysis of N-myc and c-myc double-deficient lens demonstrated that these Myc genes cooperate to drive lens growth prior to lens vesicle stage. Together, these findings provide evidence for exclusive and cooperative functions of Myc transcription factors in mouse lens development and identify novel mechanisms by which N-myc regulates cell differentiation during eye morphogenesis. (Copyright © 2017 Elsevier Inc. All rights reserved.) |
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| معلومات مُعتمدة: | R01 EY012200 United States EY NEI NIH HHS; R01 EY014237 United States EY NEI NIH HHS; R01 EY021505 United States EY NEI NIH HHS |
| فهرسة مساهمة: | Keywords: Cell cycle; Denucleation; Eye; Oncogene; Organogenesis; Transcription factor |
| المشرفين على المادة: | 0 (N-Myc Proto-Oncogene Protein) 0 (Proto-Oncogene Proteins c-myc) |
| تواريخ الأحداث: | Date Created: 20170719 Date Completed: 20171012 Latest Revision: 20181113 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC5586101 |
| DOI: | 10.1016/j.ydbio.2017.07.002 |
| PMID: | 28716713 |
| قاعدة البيانات: | MEDLINE |
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