دورية أكاديمية
Psychostimulant effect of dopaminergic treatment and addictions in Parkinson's disease.
| العنوان: | Psychostimulant effect of dopaminergic treatment and addictions in Parkinson's disease. |
|---|---|
| المؤلفون: | Delpont B; Movement Disorders Unit, Neurology Department, CHU Grenoble Alpes and Université Grenoble Alpes, Grenoble, France., Lhommée E; Movement Disorders Unit, Neurology Department, CHU Grenoble Alpes and Université Grenoble Alpes, Grenoble, France.; Grenoble Institut des Neurosciences, Inserm, U1216, Grenoble, France., Klinger H; Service de Neurologie C, Université Lyon I, Hospices Civils de Lyon, Hôpital Neurologique Pierre Wertheimer, Lyon, France.; CNRS, UMR 5229, Centre de Neurosciences Cognitives, Lyon, France., Schmitt E; Movement Disorders Unit, Neurology Department, CHU Grenoble Alpes and Université Grenoble Alpes, Grenoble, France.; Grenoble Institut des Neurosciences, Inserm, U1216, Grenoble, France., Bichon A; Movement Disorders Unit, Neurology Department, CHU Grenoble Alpes and Université Grenoble Alpes, Grenoble, France.; Grenoble Institut des Neurosciences, Inserm, U1216, Grenoble, France., Fraix V; Movement Disorders Unit, Neurology Department, CHU Grenoble Alpes and Université Grenoble Alpes, Grenoble, France.; Grenoble Institut des Neurosciences, Inserm, U1216, Grenoble, France., Castrioto A; Movement Disorders Unit, Neurology Department, CHU Grenoble Alpes and Université Grenoble Alpes, Grenoble, France.; Grenoble Institut des Neurosciences, Inserm, U1216, Grenoble, France., Quesada JL; Unité Scientifique de la DRCI et Centre d'Investigation Clinique, CHU de Grenoble, Grenoble, France., Pélissier P; Movement Disorders Unit, Neurology Department, CHU Grenoble Alpes and Université Grenoble Alpes, Grenoble, France., Kistner A; Movement Disorders Unit, Neurology Department, CHU Grenoble Alpes and Université Grenoble Alpes, Grenoble, France., Carnicella S; Grenoble Institut des Neurosciences, Inserm, U1216, Grenoble, France., Lüscher C; Department of Basic Neurosciences, Medical Faculty, University of Geneva, Geneva, Switzerland; Clinic of Neurology, Department of Clinical Neurosciences, Geneva University Hospital, Geneva, Switzerland., Broussolle E; Service de Neurologie C, Université Lyon I, Hospices Civils de Lyon, Hôpital Neurologique Pierre Wertheimer, Lyon, France.; CNRS, UMR 5229, Centre de Neurosciences Cognitives, Lyon, France., Pollak P; Department of Basic Neurosciences, Medical Faculty, University of Geneva, Geneva, Switzerland; Clinic of Neurology, Department of Clinical Neurosciences, Geneva University Hospital, Geneva, Switzerland., Thobois S; Service de Neurologie C, Université Lyon I, Hospices Civils de Lyon, Hôpital Neurologique Pierre Wertheimer, Lyon, France.; CNRS, UMR 5229, Centre de Neurosciences Cognitives, Lyon, France., Krack P; Movement Disorders Unit, Neurology Department, CHU Grenoble Alpes and Université Grenoble Alpes, Grenoble, France.; Grenoble Institut des Neurosciences, Inserm, U1216, Grenoble, France.; Department of Basic Neurosciences, Medical Faculty, University of Geneva, Geneva, Switzerland; Clinic of Neurology, Department of Clinical Neurosciences, Geneva University Hospital, Geneva, Switzerland. |
| المصدر: | Movement disorders : official journal of the Movement Disorder Society [Mov Disord] 2017 Nov; Vol. 32 (11), pp. 1566-1573. Date of Electronic Publication: 2017 Jul 24. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8610688 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1531-8257 (Electronic) Linking ISSN: 08853185 NLM ISO Abbreviation: Mov Disord Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2001->: New York, NY : Wiley-Liss Original Publication: [New York, N.Y.] : Raven Press, [c1986- |
| مواضيع طبية MeSH: | Behavior, Addictive/*physiopathology , Central Nervous System Stimulants/*adverse effects , Depressive Disorder/*physiopathology , Dopamine Agents/*adverse effects , Euphoria/*drug effects , Levodopa/*adverse effects , Parkinson Disease/*physiopathology , Substance-Related Disorders/*physiopathology, Aged ; Behavior, Addictive/chemically induced ; Dyskinesia, Drug-Induced/physiopathology ; Female ; Humans ; Male ; Middle Aged ; Parkinson Disease/drug therapy ; Prospective Studies |
| مستخلص: | Background: Dopamine replacement therapy in PD has been associated with both behavioral addictions and dopamine addiction. Objectives: To investigate potential association between l-dopa induced neuropsychiatric fluctuations and addictions in PD. Methods: A cohort of 102 patients with PD suffering from motor complications of l-dopa treatment was prospectively analyzed. We evaluated dopamine addiction, behavioral addictions, and neuropsychiatric fluctuations using the Ardouin scale of behavior in PD. Results: Patients with (n = 51) or without (n = 51) neuropsychiatric fluctuations did not differ in age, disease duration, medication, or UPDRS III motor score during on and off drug condition. Patients with neuropsychiatric fluctuations had a higher H & Y stage in off-drug condition. A multivariate model showed that dopamine addiction (odds ratio: 8.9; P = 0.02) and behavioral addictions (odds ratio: 3.76; P = 0.033) were more frequent in the presence of neuropsychiatric fluctuations. Behavioral addictions and dopamine addiction were more frequent in the presence than in the absence of on-drug euphoria (46% vs. 13.9%; P < 0.001 and 27% vs 6.2 %; P = 0.003), while conversely, no association emerged between dopamine or behavioral addictions and presence of off-drug dysphoria. Patients with neuropsychiatric fluctuations had a poorer quality of life and a more frequent history of anxiety disorder. Conclusions: The psychostimulant effects of dopamine treatment during on-drug euphoria, rather than avoidance of off-drug dysphoria, appear to drive both behavioral addictions and abuse of medication. © 2017 International Parkinson and Movement Disorder Society. (© 2017 International Parkinson and Movement Disorder Society.) |
| فهرسة مساهمة: | Keywords: Parkinson's disease; addictions; dopamine dysregulation syndrome; impulsive control disorders; nonmotor fluctuations |
| المشرفين على المادة: | 0 (Central Nervous System Stimulants) 0 (Dopamine Agents) 46627O600J (Levodopa) |
| تواريخ الأحداث: | Date Created: 20170725 Date Completed: 20180625 Latest Revision: 20220321 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1002/mds.27101 |
| PMID: | 28737225 |
| قاعدة البيانات: | MEDLINE |
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