دورية أكاديمية
Dietary Modulation of Oxidative Stress in Alzheimer's Disease.
| العنوان: | Dietary Modulation of Oxidative Stress in Alzheimer's Disease. |
|---|---|
| المؤلفون: | Thapa A; Department of Chemical and Biological Engineering and the Center for Biomedical Engineering, University of New Mexico, Albuquerque, NM 87131, USA. athapa@unm.edu., Carroll NJ; Department of Chemical and Biological Engineering and the Center for Biomedical Engineering, University of New Mexico, Albuquerque, NM 87131, USA. ncarroll@unm.edu. |
| المصدر: | International journal of molecular sciences [Int J Mol Sci] 2017 Jul 21; Vol. 18 (7). Date of Electronic Publication: 2017 Jul 21. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI, [2000- |
| مواضيع طبية MeSH: | Alzheimer Disease/*prevention & control , Antioxidants/*pharmacology , Reactive Oxygen Species/*metabolism, Alzheimer Disease/metabolism ; Antioxidants/administration & dosage ; Dietary Supplements ; Flavonoids/administration & dosage ; Flavonoids/pharmacology ; Humans ; Minerals/administration & dosage ; Minerals/pharmacology ; Oxidative Stress/drug effects ; Polyphenols/administration & dosage ; Polyphenols/pharmacology |
| مستخلص: | Cells generate unpaired electrons, typically via oxygen- or nitrogen-based by-products during normal cellular respiration and under stressed situations. These pro-oxidant molecules are highly unstable and may oxidize surrounding cellular macromolecules. Under normal conditions, the reactive oxygen or nitrogen species can be beneficial to cell survival and function by destroying and degrading pathogens or antigens. However, excessive generation and accumulation of the reactive pro-oxidant species over time can damage proteins, lipids, carbohydrates, and nucleic acids. Over time, this oxidative stress can contribute to a range of aging-related degenerative diseases such as cancer, diabetes, macular degeneration, and Alzheimer's, and Parkinson's diseases. It is well accepted that natural compounds, including vitamins A, C, and E, β-carotene, and minerals found in fruits and vegetables are powerful anti-oxidants that offer health benefits against several different oxidative stress induced degenerative diseases, including Alzheimer's disease (AD). There is increasing interest in developing anti-oxidative therapeutics to prevent AD. There are contradictory and inconsistent reports on the possible benefits of anti-oxidative supplements; however, fruits and vegetables enriched with multiple anti-oxidants (e.g., flavonoids and polyphenols) and minerals may be highly effective in attenuating the harmful effects of oxidative stress. As the physiological activation of either protective or destructive pro-oxidant behavior remains relatively unclear, it is not straightforward to relate the efficacy of dietary anti-oxidants in disease prevention. Here, we review oxidative stress mediated toxicity associated with AD and highlight the modulatory roles of natural dietary anti-oxidants in preventing AD. Competing Interests: The authors declare no conflicts of interest. |
| References: | Free Radic Biol Med. 2013 Sep;62:157-69. (PMID: 23044265) Neurosci Lett. 2008 Jul 25;440(1):44-8. (PMID: 18539391) Biofactors. 1998;7(1-2):41-50. (PMID: 9523027) J Gerontol. 1956 Jul;11(3):298-300. (PMID: 13332224) Free Radic Biol Med. 1996;20(1):121-7. (PMID: 8903688) Curr Med Chem. 2005;12(10):1161-208. (PMID: 15892631) Neuroscience. 2010 Sep 1;169(3):1296-306. (PMID: 20538041) Trends Mol Med. 2001 Dec;7(12):548-54. (PMID: 11733217) JAMA. 2008 Nov 19;300(19):2253-62. (PMID: 19017911) Phytomedicine. 2014 May 15;21(6):888-92. (PMID: 24548724) Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12197-202. (PMID: 12213959) Science. 2002 Jul 19;297(5580):353-6. (PMID: 12130773) J Signal Transduct. 2012;2012:646354. (PMID: 21977319) FASEB J. 2003 Jul;17(10):1195-214. (PMID: 12832285) MMW Fortschr Med. 2002 Oct 10;144(41):33-7. (PMID: 12474358) J Biol Chem. 2002 Oct 25;277(43):40173-6. (PMID: 12198111) Biochim Biophys Acta. 2012 May;1822(5):631-8. (PMID: 22019723) Expert Rev Neurother. 2015 Jun;15(6):629-37. (PMID: 26035622) Invest Ophthalmol Vis Sci. 2010 Nov;51(11):5470-9. (PMID: 20505194) Nutr J. 2004 May 12;3:5. (PMID: 15140261) Am J Med. 1991 Sep 30;91(3C):14S-22S. (PMID: 1928205) Pathophysiology. 2006 Aug;13(3):195-208. (PMID: 16781128) Int J Mol Sci. 2016 Oct 26;17 (11):. (PMID: 27792188) Redox Biol. 2013 Dec 04;2:28-35. (PMID: 24371802) Gerontology. 2007;53(3):128-39. (PMID: 17164550) Int J Mol Sci. 2017 Mar 23;18(4):. (PMID: 28333071) Chem Rev. 2012 Oct 10;112(10):5147-92. (PMID: 22813427) Biochemistry. 2011 Apr 5;50(13):2445-55. (PMID: 21322641) Neuroscience. 2015 Sep 24;304:340-8. (PMID: 26197225) J Biomed Biotechnol. 2004;2004(4):227-237. (PMID: 15467163) J Alzheimers Dis. 2009;17(1):143-9. (PMID: 19494439) J Biol Chem. 2005 Feb 18;280(7):5892-901. (PMID: 15590663) Am J Epidemiol. 2006 Nov 1;164(9):898-906. (PMID: 16870699) Nutrition. 2017 Jan;33:311-321. (PMID: 27746034) Nature. 2000 Nov 9;408(6809):239-47. (PMID: 11089981) J Natl Cancer Inst. 2006 Feb 15;98(4):245-54. (PMID: 16478743) Oxid Med Cell Longev. 2016;2016:5698931. (PMID: 26881031) Biochim Biophys Acta. 2010 Mar;1802(3):322-30. (PMID: 20026206) J Amino Acids. 2011;2011:198430. (PMID: 22312456) Curr Neuropharmacol. 2011 Dec;9(4):662-73. (PMID: 22654724) Ren Fail. 2017 Nov;39(1):130-139. (PMID: 27841100) Curr Pharm Des. 2006;12(33):4357-75. (PMID: 17105432) J Pharm Pharmacol. 2008 Aug;60(8):969-76. (PMID: 18644190) Nutrients. 2012 Oct 09;4(10):1399-440. (PMID: 23201762) Biochim Biophys Acta. 2006 Jun;1762(6):575-86. (PMID: 16644188) Annu Rev Biochem. 1995;64:97-112. (PMID: 7574505) Cell Mol Neurobiol. 1995 Oct;15(5):513-26. (PMID: 8719038) Acta Pharmacol Sin. 2011 May;32(5):545-51. (PMID: 21499284) Curr Alzheimer Res. 2005 Apr;2(2):131-6. (PMID: 15974909) Alzheimers Dement. 2016 Oct;12 (10 ):1066-1077. (PMID: 27133892) Oxid Med Cell Longev. 2012;2012:480895. (PMID: 22655114) Chem Biol Interact. 2008 Jul 10;174(1):27-37. (PMID: 18547552) Inhal Toxicol. 2007 Jul;19(9):767-9. (PMID: 17613085) Eur J Clin Nutr. 2003 Aug;57(8):999-1008. (PMID: 12879095) Bratisl Lek Listy. 2006;107(9-10):384-94. (PMID: 17262991) Antioxid Redox Signal. 2013 Sep 10;19(8):823-35. (PMID: 23249141) Biochim Biophys Acta. 2011 Nov;1812(11):1359-70. (PMID: 21871956) Redox Biol. 2014;2:165-9. (PMID: 25460727) Curr Pharm Des. 2010;16(25):2766-78. (PMID: 20698820) Exp Neurobiol. 2015 Dec;24(4):325-40. (PMID: 26713080) Biochim Biophys Acta. 2007 Aug;1768(8):1976-90. (PMID: 17433250) Front Pharmacol. 2016 Feb 12;7:24. (PMID: 26903869) J Neurochem. 2006 Jan;96(2):561-72. (PMID: 16336627) J Agric Food Chem. 2016 May 11;64(18):3598-608. (PMID: 27094403) Oxid Med Cell Longev. 2014;2014:427318. (PMID: 24669288) Biomed J. 2014 May-Jun;37(3):106-11. (PMID: 24923567) Anticancer Agents Med Chem. 2008 Oct;8(7):807-16. (PMID: 18855582) J Med Chem. 2006 Nov 16;49(23):6742-59. (PMID: 17154505) Lancet. 2006 Jul 29;368(9533):387-403. (PMID: 16876668) Redox Biol. 2013 Jan 30;1:80-5. (PMID: 24024140) J Biol Chem. 2012 Feb 24;287(9):6912-27. (PMID: 22219198) J Neuropathol Exp Neurol. 2010 Feb;69(2):155-67. (PMID: 20084018) Curr Top Cell Regul. 1996;34:159-87. (PMID: 8646847) Clin Interv Aging. 2007;2(3):377-87. (PMID: 18044188) FASEB J. 2004 Feb;18(2):323-5. (PMID: 14656990) Oxid Med Cell Longev. 2013;2013:729804. (PMID: 23861994) Mol Neurobiol. 2015 Apr;51(2):466-79. (PMID: 24826916) J Physiol. 2003 Oct 15;552(Pt 2):335-44. (PMID: 14561818) Ann Intern Med. 2005 Jan 4;142(1):37-46. (PMID: 15537682) Biochem Pharmacol. 1997 Mar 7;53(5):733-40. (PMID: 9113093) Int J Food Sci Nutr. 2013 May;64(3):312-26. (PMID: 23121370) J Biol Chem. 2011 Dec 30;286(52):44557-68. (PMID: 22072713) Free Radic Biol Med. 2014 Sep;74:50-63. (PMID: 24960578) Eur J Pharmacol. 2006 Sep 1;545(1):51-64. (PMID: 16904103) PLoS One. 2014 Feb 10;9(2):e88359. (PMID: 24520374) J Neuropathol Exp Neurol. 2008 May;67(5):377-87. (PMID: 18431258) Biochem Res Int. 2011;2011:784698. (PMID: 21826271) J Alzheimers Dis. 2010;19(1):27-30. (PMID: 20061623) Physiol Rev. 2002 Jan;82(1):47-95. (PMID: 11773609) J Biol Chem. 2001 Oct 19;276(42):38388-93. (PMID: 11507097) Biol Bull. 2013 Feb;224(1):18-28. (PMID: 23493505) Cell. 2005 Feb 25;120(4):437-47. (PMID: 15734677) Caspian J Intern Med. 2016 Spring;7(2):88-92. (PMID: 27386059) Pharm Res. 2004 Jul;21(7):1263-73. (PMID: 15290869) AAPS J. 2013 Jan;15(1):195-218. (PMID: 23143785) Am J Clin Nutr. 1995 Dec;62(6 Suppl):1322S-1326S. (PMID: 7495227) Biomed Res Int. 2014;2014:761264. (PMID: 24587990) J Med Chem. 2010 Nov 25;53(22):7992-9. (PMID: 21038854) J Biol Chem. 2005 Apr 29;280(17):17294-300. (PMID: 15722360) Exp Gerontol. 2001 Sep;36(9):1539-50. (PMID: 11525876) Nat Med. 1998 Oct;4(10):1189-92. (PMID: 9771755) Am J Pathol. 2009 Dec;175(6):2557-65. (PMID: 19893028) J Diabetes Metab Disord. 2012 Aug 02;11(1):3. (PMID: 23497678) Metallomics. 2015 Aug;7(8):1213-28. (PMID: 25996565) Int J Biochem Cell Biol. 2007;39(1):44-84. (PMID: 16978905) Nat Rev Cancer. 2003 Apr;3(4):276-85. (PMID: 12671666) Adv Exp Med Biol. 2015;863:55-77. (PMID: 26092626) |
| فهرسة مساهمة: | Keywords: Alzheimer’s disease; anti-oxidant; degenerative disease; diet; flavonoid; oxidative stress; polyphenol; pro-oxidant; protective function |
| المشرفين على المادة: | 0 (Antioxidants) 0 (Flavonoids) 0 (Minerals) 0 (Polyphenols) 0 (Reactive Oxygen Species) |
| تواريخ الأحداث: | Date Created: 20170730 Date Completed: 20180426 Latest Revision: 20181113 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC5536070 |
| DOI: | 10.3390/ijms18071583 |
| PMID: | 28753984 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1422-0067 |
|---|---|
| DOI: | 10.3390/ijms18071583 |