دورية أكاديمية
أعرض في EDS

Fifteen Genetic Loci Associated With the Electrocardiographic P Wave.

التفاصيل البيبلوغرافية
العنوان: Fifteen Genetic Loci Associated With the Electrocardiographic P Wave.
المؤلفون: Christophersen IE, Magnani JW, Yin X, Barnard J, Weng LC, Arking DE, Niemeijer MN, Lubitz SA, Avery CL, Duan Q, Felix SB, Bis JC, Kerr KF, Isaacs A, Müller-Nurasyid M, Müller C, North KE, Reiner AP, Tinker LF, Kors JA, Teumer A, Petersmann A, Sinner MF, Buzkova P, Smith JD, Van Wagoner DR, Völker U, Waldenberger M, Peters A, Meitinger T, Limacher MC, Wilhelmsen KC, Psaty BM, Hofman A, Uitterlinden A, Krijthe BP, Zhang ZM, Schnabel RB, Kääb S, van Duijn C, Rotter JI, Sotoodehnia N, Dörr M, Li Y, Chung MK, Soliman EZ, Alonso A, Whitsel EA, Stricker BH, Benjamin EJ, Heckbert SR, Ellinor PT
المصدر: Circulation. Cardiovascular genetics [Circ Cardiovasc Genet] 2017 Aug; Vol. 10 (4).
نوع المنشور: Journal Article; Meta-Analysis
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 101489144 Publication Model: Print Cited Medium: Internet ISSN: 1942-3268 (Electronic) Linking ISSN: 19423268 NLM ISO Abbreviation: Circ Cardiovasc Genet Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Hagerstown, MD : Lippincott Williams & Wilkins
مواضيع طبية MeSH: Electrocardiography* , Genetic Loci* , Genome-Wide Association Study*, Arrhythmias, Cardiac/genetics ; Arrhythmias, Cardiac/physiopathology ; Caveolin 1/genetics ; Caveolin 2/genetics ; Genotype ; Heart Atria/metabolism ; Humans ; NAV1.5 Voltage-Gated Sodium Channel/genetics ; NAV1.8 Voltage-Gated Sodium Channel/genetics ; T-Box Domain Proteins/genetics
مستخلص: Background: The P wave on an ECG is a measure of atrial electric function, and its characteristics may serve as predictors for atrial arrhythmias. Increased mean P-wave duration and P-wave terminal force traditionally have been used as markers for left atrial enlargement, and both have been associated with increased risk of atrial fibrillation. Here, we explore the genetic basis of P-wave morphology through meta-analysis of genome-wide association study results for P-wave duration and P-wave terminal force from 12 cohort studies.
Methods and Results: We included 44 456 individuals, of which 6778 (16%) were of African ancestry. Genotyping, imputation, and genome-wide association study were performed at each study site. Summary-level results were meta-analyzed centrally using inverse-variance weighting. In meta-analyses of P-wave duration, we identified 6 significant ( P <5×10 - 8 ) novel loci and replicated a prior association with S CN10A. We identified 3 loci at SCN5A , TBX5 , and CAV1/CAV2 that were jointly associated with the PR interval, PR segment, and P-wave duration. We identified 6 novel loci in meta-analysis of P-wave terminal force. Four of the identified genetic loci were significantly associated with gene expression in 329 left atrial samples. Finally, we observed that some of the loci associated with the P wave were linked to overall atrial conduction, whereas others identified distinct phases of atrial conduction.
Conclusions: We have identified 6 novel genetic loci associated with P-wave duration and 6 novel loci associated with P-wave terminal force. Future studies of these loci may aid in identifying new targets for drugs that may modify atrial conduction or treat atrial arrhythmias.
(© 2017 American Heart Association, Inc.)
التعليقات: Comment in: Circ Cardiovasc Genet. 2017 Aug;10(4):. (PMID: 28794113)
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معلومات مُعتمدة: R01 HL120393 United States HL NHLBI NIH HHS; K24 HL105780 United States HL NHLBI NIH HHS; U01 HL120393 United States HL NHLBI NIH HHS; UL1 TR000124 United States TR NCATS NIH HHS; R01 HL128914 United States HL NHLBI NIH HHS; P30 DK063491 United States DK NIDDK NIH HHS; R01 HL111314 United States HL NHLBI NIH HHS; UL1 TR001881 United States TR NCATS NIH HHS; K23 HL114724 United States HL NHLBI NIH HHS; R01 HL116747 United States HL NHLBI NIH HHS; R01 HL092577 United States HL NHLBI NIH HHS; U01 HL130114 United States HL NHLBI NIH HHS; R01 HL090620 United States HL NHLBI NIH HHS; R01 HL105756 United States HL NHLBI NIH HHS
فهرسة مساهمة: Keywords: arrhythmia; atrial function; electrocardiography; genetic variation; genome-wide association study
المشرفين على المادة: 0 (CAV1 protein, human)
0 (CAV2 protein, human)
0 (Caveolin 1)
0 (Caveolin 2)
0 (NAV1.5 Voltage-Gated Sodium Channel)
0 (NAV1.8 Voltage-Gated Sodium Channel)
0 (SCN10A protein, human)
0 (SCN5A protein, human)
0 (T-Box Domain Proteins)
0 (T-box transcription factor 5)
تواريخ الأحداث: Date Created: 20170811 Date Completed: 20180112 Latest Revision: 20210615
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC5567993
DOI: 10.1161/CIRCGENETICS.116.001667
PMID: 28794112
قاعدة البيانات: MEDLINE
الوصف
تدمد:1942-3268
DOI:10.1161/CIRCGENETICS.116.001667