دورية أكاديمية
Optimization of Curcuma Oil/Quinine-Loaded Nanocapsules for Malaria Treatment.
| العنوان: | Optimization of Curcuma Oil/Quinine-Loaded Nanocapsules for Malaria Treatment. |
|---|---|
| المؤلفون: | Gomes GS; Curso de Farmácia, Universidade Federal do Pampa, UNIPAMPA, Uruguaiana, RS, 97500-970, Brazil., Maciel TR; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Pampa, UNIPAMPA, Uruguaiana, RS, 97500-970, Brazil., Piegas EM; Curso de Farmácia, Universidade Federal do Pampa, UNIPAMPA, Uruguaiana, RS, 97500-970, Brazil., Michels LR; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Pampa, UNIPAMPA, Uruguaiana, RS, 97500-970, Brazil., Colomé LM; Curso de Farmácia, Universidade Federal do Pampa, UNIPAMPA, Uruguaiana, RS, 97500-970, Brazil.; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Pampa, UNIPAMPA, Uruguaiana, RS, 97500-970, Brazil., Freddo RJ; Curso de Farmácia, Universidade Federal do Pampa, UNIPAMPA, Uruguaiana, RS, 97500-970, Brazil., Ávila DS; Programa de Pós-Graduação em Bioquímica, Universidade Federal do Pampa, UNIPAMPA, Uruguaiana, RS, 97500-970, Brazil., Gundel A; Campus Bagé, Universidade Federal do Pampa, UNIPAMPA, Travessa 45, 1650, Bagé, RS, 96413-170, Brazil., Haas SE; Curso de Farmácia, Universidade Federal do Pampa, UNIPAMPA, Uruguaiana, RS, 97500-970, Brazil. sandrahaas@unipampa.edu.br.; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Pampa, UNIPAMPA, Uruguaiana, RS, 97500-970, Brazil. sandrahaas@unipampa.edu.br. |
| المصدر: | AAPS PharmSciTech [AAPS PharmSciTech] 2018 Feb; Vol. 19 (2), pp. 551-564. Date of Electronic Publication: 2017 Sep 05. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: United States NLM ID: 100960111 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-9932 (Electronic) Linking ISSN: 15309932 NLM ISO Abbreviation: AAPS PharmSciTech Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York : Springer Original Publication: Arlington, VA : American Association of Pharmaceutical Scientists, c2000- |
| مواضيع طبية MeSH: | Curcuma*, Antimalarials/*administration & dosage , Malaria/*drug therapy , Plant Oils/*administration & dosage , Quinine/*administration & dosage, Animals ; Antimalarials/therapeutic use ; Caproates ; Drug Carriers ; Excipients ; Lactones ; Mice ; Nanocapsules/chemistry ; Particle Size ; Plant Oils/therapeutic use ; Polymers/chemistry ; Polymethacrylic Acids ; Quinine/therapeutic use |
| مستخلص: | Quinine, a treatment used in chloroquine-resistant falciparum malaria, was loaded into poly(ɛ-caprolactone) or Eudragit ® RS100 nanocapsules using Curcuma oil as the oil-based core. Until now, the effect of cationic nanocapsules on malaria has not been reported. A 2 4 factorial design was adopted using, as independent variables, the concentration of Curcuma oil, presence of quinine, type of polymer, and aqueous surfactant. Diameter, zeta potential, and pH were the responses studied. The formulations were also evaluated for drug content, encapsulation efficiency, photostability, and antimalarial activity against Plasmodium berghei-infected mice. The type of polymer influenced all of the responses studied. Quinine-loaded Eudragit ® RS100 (F13) and PCL nanocapsules (F9), both with polysorbate 80 coating, showed nanometric particle size, positive zeta potential, neutral pH, high drug content, and quinine photoprotection ability; thus, these nanocapsules were selected for in vivo tests. Both formulations showed lower levels of parasitemia from the beginning of the experiment (5.78 ± 3.60 and 4.76 ± 3.46% for F9 and F13, respectively) and highest survival mean time (15.3 ± 2.0 and 14.9 ± 5.6 days for F9 and F13, respectively). F9 and F13 showed significant survival curve compared to saline, thus demonstrating that nanoencapsulation improved bioefficacy of QN and co-encapsulated curcuminoids, regardless of the surface charge. |
| فهرسة مساهمة: | Keywords: Curcuma oil; Eudragit® RS100; Malaria; Nanoparticles; Poloxamer; Quinine |
| المشرفين على المادة: | 0 (Antimalarials) 0 (Caproates) 0 (Drug Carriers) 0 (Excipients) 0 (Lactones) 0 (Nanocapsules) 0 (Plant Oils) 0 (Polymers) 0 (Polymethacrylic Acids) 25086-15-1 (methylmethacrylate-methacrylic acid copolymer) 56RE988L1R (caprolactone) A7V27PHC7A (Quinine) |
| تواريخ الأحداث: | Date Created: 20170907 Date Completed: 20180622 Latest Revision: 20181202 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1208/s12249-017-0854-6 |
| PMID: | 28875471 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1530-9932 |
|---|---|
| DOI: | 10.1208/s12249-017-0854-6 |