دورية أكاديمية
أعرض في EDS

Intermittent hypoxia-induced insulin resistance is associated with alterations in white fat distribution.

التفاصيل البيبلوغرافية
العنوان: Intermittent hypoxia-induced insulin resistance is associated with alterations in white fat distribution.
المؤلفون: Poulain L; Université Grenoble Alpes, Laboratoire HP2, Grenoble, F-38042, France.; Inserm U1042, Laboratoire HP2, Grenoble, F-38042, France., Mathieu H; Université Grenoble Alpes, IRMaGe, Grenoble, F-38000, France.; Inserm, US017, Grenoble, F-38043, France.; CNRS, UMS 3552, Grenoble, F-38043, France.; CHU Grenoble-Alpes, IRMaGe, Grenoble, F-38000, France.; Inserm, U1216, Grenoble, F-38000, France., Thomas A; Université Grenoble Alpes, Laboratoire HP2, Grenoble, F-38042, France.; Inserm U1042, Laboratoire HP2, Grenoble, F-38042, France., Borel AL; Université Grenoble Alpes, Laboratoire HP2, Grenoble, F-38042, France.; Inserm U1042, Laboratoire HP2, Grenoble, F-38042, France., Remy C; Université Grenoble Alpes, IRMaGe, Grenoble, F-38000, France.; Inserm, US017, Grenoble, F-38043, France.; CNRS, UMS 3552, Grenoble, F-38043, France.; CHU Grenoble-Alpes, IRMaGe, Grenoble, F-38000, France.; Inserm, U1216, Grenoble, F-38000, France., Levy P; Université Grenoble Alpes, Laboratoire HP2, Grenoble, F-38042, France.; Inserm U1042, Laboratoire HP2, Grenoble, F-38042, France.; CHU Grenoble-Alpes, Laboratoires du Sommeil et EFCR, Grenoble, F-38043, France., Arnaud C; Université Grenoble Alpes, Laboratoire HP2, Grenoble, F-38042, France. claire.arnaud@univ-grenoble-alpes.fr.; Inserm U1042, Laboratoire HP2, Grenoble, F-38042, France. claire.arnaud@univ-grenoble-alpes.fr., Dematteis M; Université Grenoble Alpes, Laboratoire HP2, Grenoble, F-38042, France. maurice.dematteis@univ-grenoble-alpes.fr.; Inserm U1042, Laboratoire HP2, Grenoble, F-38042, France. maurice.dematteis@univ-grenoble-alpes.fr.; CHU Grenoble-Alpes, Service d'Addictologie, Grenoble, F-38043, France. maurice.dematteis@univ-grenoble-alpes.fr.
المصدر: Scientific reports [Sci Rep] 2017 Sep 11; Vol. 7 (1), pp. 11180. Date of Electronic Publication: 2017 Sep 11.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Body Fat Distribution* , Insulin Resistance*, Adipose Tissue, White/*anatomy & histology , Hypoxia/*pathology , Sleep Apnea Syndromes/*pathology, Animals ; Disease Models, Animal ; Epididymis/pathology ; Male ; Mice, Inbred C57BL ; Peritoneum/pathology ; Skin/pathology
مستخلص: Sleep apnea syndrome is characterized by repetitive upper airway collapses during night leading to intermittent hypoxia (IH). The latter is responsible for metabolic disturbances that rely, at least in part, on abdominal white fat inflammation. Besides qualitative alterations, we hypothesized that IH could also modify body fat distribution, a key factor for metabolic complications. C57BL6 mice exposed to IH (21-5% FiO 2 , 60 s cycle, 8 h/day) or air for 6 weeks were investigated for topographic fat alterations (whole-body MRI). Specific role of epididymal fat in IH-induced metabolic dysfunctions was assessed in lipectomized or sham-operated mice exposed to IH or air. Whereas total white fat volume was unchanged, IH induced epididymal adipose tissue (AT) loss with non-significant increase in subcutaneous and mesenteric fat. This was associated with impaired insulin sensitivity and secretion. Epididymal lipectomy led to increased subcutaneous fat in the perineal compartment and prevented IH-induced metabolic disturbances. IH led to reduced epididymal AT and impaired glucose regulation. This suggests that, rather than epididymal AT volume, qualitative fat alterations (i.e. inflammation) could represent the main determinant of metabolic dysfunction. This deterioration of glucose regulation was prevented in epididymal-lipectomized mice, possibly through prevention of IH-induced epididymal AT alterations and compensatory increase in subcutaneous AT.
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تواريخ الأحداث: Date Created: 20170913 Date Completed: 20190612 Latest Revision: 20190613
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC5593960
DOI: 10.1038/s41598-017-11782-0
PMID: 28894286
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-017-11782-0