دورية أكاديمية
Adapting Secretory Proteostasis and Function Through the Unfolded Protein Response.
| العنوان: | Adapting Secretory Proteostasis and Function Through the Unfolded Protein Response. |
|---|---|
| المؤلفون: | Wong MY; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA, 02139-4307, USA., DiChiara AS; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA, 02139-4307, USA., Suen PH; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA, 02139-4307, USA., Chen K; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA, 02139-4307, USA., Doan ND; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA, 02139-4307, USA., Shoulders MD; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA, 02139-4307, USA. mshoulde@mit.edu. |
| المصدر: | Current topics in microbiology and immunology [Curr Top Microbiol Immunol] 2018; Vol. 414, pp. 1-25. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0110513 Publication Model: Print Cited Medium: Print ISSN: 0070-217X (Print) Linking ISSN: 0070217X NLM ISO Abbreviation: Curr Top Microbiol Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Heidelberg : Springer Verlag |
| مواضيع طبية MeSH: | Proteostasis/*physiology , Unfolded Protein Response/*physiology, Animals ; Endoplasmic Reticulum/metabolism ; Humans ; Protein Folding |
| مستخلص: | Cells address challenges to protein folding in the secretory pathway by engaging endoplasmic reticulum (ER)-localized protective mechanisms that are collectively termed the unfolded protein response (UPR). By the action of the transmembrane signal transducers IRE1, PERK, and ATF6, the UPR induces networks of genes whose products alleviate the burden of protein misfolding. The UPR also plays instructive roles in cell differentiation and development, aids in the response to pathogens, and coordinates the output of professional secretory cells. These functions add to and move beyond the UPR's classical role in addressing proteotoxic stress. Thus, the UPR is not just a reaction to protein misfolding, but also a fundamental driving force in physiology and pathology. Recent efforts have yielded a suite of chemical genetic methods and small molecule modulators that now provide researchers with both stress-dependent and -independent control of UPR activity. Such tools provide new opportunities to perturb the UPR and thereby study mechanisms for maintaining proteostasis in the secretory pathway. Numerous observations now hint at the therapeutic potential of UPR modulation for diseases related to the misfolding and aggregation of ER client proteins. Growing evidence also indicates the promise of targeting ER proteostasis nodes downstream of the UPR. Here, we review selected advances in these areas, providing a resource to inform ongoing studies of secretory proteostasis and function as they relate to the UPR. |
| References: | Mol Cell Biol. 2003 Nov;23 (21):7448-59. (PMID: 14559994) J Biol Chem. 2016 Apr 29;291(18):9526-39. (PMID: 26945068) ACS Chem Biol. 2016 Jan 15;11(1):200-10. (PMID: 26502114) Nature. 2010 Feb 25;463(7284):1092-5. (PMID: 20182512) Cell. 2016 Dec 15;167(7):1867-1882.e21. (PMID: 27984733) Nat Chem Biol. 2013 Sep;9(9):548-56. (PMID: 23892893) Cell Stress Chaperones. 2009 Jan;14(1):105-11. (PMID: 18663603) J Biol Chem. 2003 Nov 28;278(48):48330-8. (PMID: 12970348) Nat Cell Biol. 2016 Nov;18(11):1173-1184. (PMID: 27749824) Nature. 2013 Nov 14;503(7475):272-6. (PMID: 24089213) Science. 2001 Sep 28;293(5539):2459-62. (PMID: 11577236) Cell. 2014 Jul 31;158(3):534-48. (PMID: 25018104) Cell. 1993 Jun 18;73(6):1197-206. (PMID: 8513503) PLoS Biol. 2008 Feb;6(2):e26. (PMID: 18254660) PLoS Biol. 2010 Jul 06;8(7):e1000415. (PMID: 20625545) Cell. 2006 Sep 8;126(5):995-1004. (PMID: 16959577) J Biol Chem. 2006 Jul 7;281(27):18691-706. (PMID: 16644724) Biochim Biophys Acta. 2013 Nov;1833(11):2430-7. (PMID: 23583305) Nat Chem Biol. 2017 Jan;13(1):9-11. (PMID: 27820801) Nature. 2014 Apr 3;508(7494):103-107. (PMID: 24670641) Cell. 2009 Jan 23;136(2):272-83. (PMID: 19167329) Dev Cell. 2007 Sep;13(3):351-64. (PMID: 17765679) Mol Biol Cell. 2017 Aug 15;28(17 ):2318-2332. (PMID: 28615323) Nature. 2001 Jul 19;412(6844):300-7. (PMID: 11460154) Protein Sci. 2016 Dec;25(12 ):2209-2215. (PMID: 27667530) Cell. 2008 Sep 5;134(5):769-81. (PMID: 18775310) J Cell Biol. 2009 Aug 10;186(3):323-31. (PMID: 19651891) Nat Cell Biol. 2011 Nov 27;14 (1):93-105. (PMID: 22119785) Nature. 1999 Jan 21;397(6716):271-4. (PMID: 9930704) Genes Dev. 1998 Jun 15;12(12):1812-24. (PMID: 9637683) Proc Natl Acad Sci U S A. 1996 Jul 23;93(15):7690-4. (PMID: 8755537) J Biol Chem. 2011 Apr 8;286(14 ):12743-55. (PMID: 21303903) Mol Cell. 2000 Nov;6(5):1099-108. (PMID: 11106749) Nat Cell Biol. 2012 Feb 02;14(2):117-23. (PMID: 22298039) Mol Biol Cell. 2004 Apr;15(4):1635-46. (PMID: 14767067) Science. 2005 Feb 11;307(5711):935-9. (PMID: 15705855) Int J Cancer. 2009 Dec 15;125(12):2792-801. (PMID: 19544563) J Biol Chem. 2011 Dec 16;286(50):43454-64. (PMID: 22006919) Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):4834-9. (PMID: 21383145) Science. 2011 Apr 1;332(6025):91-4. (PMID: 21385720) J Am Chem Soc. 2013 Jun 5;135(22):8129-32. (PMID: 23682758) Immunity. 2004 Jul;21(1):81-93. (PMID: 15345222) Chem Biol. 2014 Aug 14;21(8):967-76. (PMID: 25126989) Cell. 2001 Dec 28;107(7):881-91. (PMID: 11779464) PLoS One. 2009;4(1):e4170. (PMID: 19137072) Elife. 2015 May 19;4:null. (PMID: 25986605) J Cell Biol. 2004 Feb 2;164(3):341-6. (PMID: 14757749) J Biol Chem. 2012 Feb 10;287(7):4679-89. (PMID: 22194594) Chem Biol. 2014 Nov 20;21(11):1564-74. (PMID: 25444553) Cancer Chemother Pharmacol. 1998;42(4):273-9. (PMID: 9744771) Science. 2016 Feb 19;351(6275):871-5. (PMID: 26822609) Proc Natl Acad Sci U S A. 2012 Apr 10;109 (15):E869-78. (PMID: 22315414) Proc Natl Acad Sci U S A. 2004 Aug 3;101(31):11269-74. (PMID: 15277680) Blood. 2012 Jun 14;119(24):5772-81. (PMID: 22538852) Nature. 2015 Jun 18;522(7556):354-8. (PMID: 26040720) J Virol. 2017 Jan 31;91(4):. (PMID: 27928013) Cell Rep. 2013 Nov 14;5(3):791-801. (PMID: 24183663) J Med Chem. 2012 Sep 13;55(17):7786-95. (PMID: 22938030) Elife. 2017 Apr 27;6:. (PMID: 28447936) Elife. 2015 Feb 18;4:null. (PMID: 25692299) J Cell Biol. 2009 Nov 16;187(4):525-36. (PMID: 19948500) EMBO J. 2015 Jan 2;34(1):4-19. (PMID: 25361606) Science. 2003 Jan 31;299(5607):713-6. (PMID: 12560553) Mol Cell Biol. 2002 Jan;22(2):626-34. (PMID: 11756557) Chem Biol. 2013 Mar 21;20(3):403-15. (PMID: 23434032) J Biol Chem. 1999 Sep 24;274(39):27392-8. (PMID: 10488070) Biochem Biophys Res Commun. 2008 Jan 25;365(4):777-83. (PMID: 18035051) J Biol Chem. 2013 Jan 11;288(2):859-72. (PMID: 23184933) Cell. 2014 Mar 13;156(6):1179-1192. (PMID: 24630721) Cell. 2014 Mar 13;156(6):1167-1178. (PMID: 24630720) Invest Ophthalmol Vis Sci. 2012 Oct 01;53(11):7159-66. (PMID: 22956602) EMBO J. 2007 Jan 10;26(1):242-52. (PMID: 17170705) Chem Biol. 2015 Oct 22;22(10 ):1301-12. (PMID: 26496683) Elife. 2015 Feb 26;4:null. (PMID: 25719440) Cell. 2013 Jun 20;153(7):1435-47. (PMID: 23791175) Nat Commun. 2015 Jul 29;6:7887. (PMID: 26219498) Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13046-51. (PMID: 25157167) ACS Chem Biol. 2016 May 20;11(5):1408-21. (PMID: 26848503) J Am Chem Soc. 2012 Jun 13;134(23):9796-804. (PMID: 22642269) J Med Chem. 2016 Apr 14;59(7):3471-88. (PMID: 27003516) Science. 2015 Apr 10;348(6231):239-42. (PMID: 25859045) J Biol Chem. 2011 Dec 2;286(48):41563-77. (PMID: 21976666) Science. 2003 Nov 28;302(5650):1533-7. (PMID: 14564015) Dev Cell. 2015 Dec 7;35(5):553-567. (PMID: 26651292) Nature. 2002 Jan 3;415(6867):92-6. (PMID: 11780124) J Bone Miner Res. 2016 Aug;31(8):1608-1616. (PMID: 26925839) Antioxid Redox Signal. 2007 Dec;9(12):2277-93. (PMID: 17979528) Science. 2011 Nov 25;334(6059):1086-90. (PMID: 22116878) Chem Biol. 2010 Sep 24;17(9):981-8. (PMID: 20851347) ACS Med Chem Lett. 2013 Nov 14;4(11):null. (PMID: 24312699) Cell. 2001 Dec 28;107(7):893-903. (PMID: 11779465) Blood. 2006 Jun 15;107(12):4907-16. (PMID: 16507771) Nature. 2016 Nov 09;539(7628):207-216. (PMID: 27830778) Hum Mol Genet. 2005 Aug 15;14(16):2387-98. (PMID: 16000318) Nature. 2011 May 26;473(7348):528-31. (PMID: 21532591) Nat Rev Immunol. 2006 Feb;6(2):136-47. (PMID: 16491138) Biochem J. 2002 Sep 1;366(Pt 2):585-94. (PMID: 12014989) Mol Cancer Ther. 2015 Mar;14 (3):642-8. (PMID: 25564440) EMBO J. 2004 Jan 14;23(1):169-79. (PMID: 14713949) Cell. 2013 Oct 10;155(2):321-32. (PMID: 24120133) Chem Biol. 2012 Jan 27;19(1):99-115. (PMID: 22284358) Nat Chem Biol. 2014 Nov;10(11):884-91. (PMID: 25325699) J Biol Chem. 2008 Mar 21;283(12 ):7445-54. (PMID: 18199748) Nat Chem Biol. 2010 Jun;6(6):424-32. (PMID: 20453863) Genomics. 2005 Dec;86(6):627-37. (PMID: 16269234) Curr Opin Cell Biol. 2015 Apr;33:67-73. (PMID: 25543896) Nat Immunol. 2010 May;11(5):411-8. (PMID: 20351694) Nat Chem Biol. 2012 Dec;8(12 ):982-9. (PMID: 23086298) Nat Chem Biol. 2014 Nov;10(11):957-62. (PMID: 25242550) PLoS Biol. 2006 Nov;4(12 ):e423. (PMID: 17132049) Cell Rep. 2013 Apr 25;3(4):1279-92. (PMID: 23583182) Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):E6790-7. (PMID: 26598709) PLoS Biol. 2006 Nov;4(11):e374. (PMID: 17090218) J Biol Chem. 2015 Jan 2;290(1):325-37. (PMID: 25406314) Nat Chem Biol. 2013 Nov;9(11):677-84. (PMID: 23995768) Nat Commun. 2016 Jun 10;7:11786. (PMID: 27283361) Cell. 2014 Sep 11;158(6):1375-1388. (PMID: 25215493) Proc Natl Acad Sci U S A. 1994 Aug 30;91(18):8324-8. (PMID: 8078881) Elife. 2016 Jul 20;5:. (PMID: 27435962) Cell Host Microbe. 2013 May 15;13(5):558-569. (PMID: 23684307) Science. 2011 Nov 25;334(6059):1081-6. (PMID: 22116877) Cell. 2009 Aug 7;138(3):562-75. (PMID: 19665977) Lancet. 2016 Apr 16;387(10028):1657-71. (PMID: 26542481) Cell. 2016 Dec 15;167(7):1853-1866.e17. (PMID: 27984732) Mol Biol Cell. 2015 Aug 15;26(16):2873-84. (PMID: 26108623) Cell Death Differ. 2006 Mar;13(3):385-92. (PMID: 16397584) Cell Struct Funct. 2008;33(1):75-89. (PMID: 18360008) Elife. 2016 Jul 20;5:. (PMID: 27435961) J Biol Chem. 2002 Dec 13;277(50):49047-54. (PMID: 12374812) Nat Struct Mol Biol. 2017 Jan;24(1):23-29. (PMID: 27918543) Mol Biol Cell. 1999 Nov;10(11):3787-99. (PMID: 10564271) Nature. 2011 Jul 20;475(7356):324-32. (PMID: 21776078) J Mol Biol. 2012 Aug 10;421(2-3):185-203. (PMID: 22244854) |
| معلومات مُعتمدة: | R01 AR071443 United States AR NIAMS NIH HHS |
| تواريخ الأحداث: | Date Created: 20170921 Date Completed: 20180920 Latest Revision: 20191008 |
| رمز التحديث: | 20240829 |
| مُعرف محوري في PubMed: | PMC5860992 |
| DOI: | 10.1007/82_2017_56 |
| PMID: | 28929194 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0070-217X |
|---|---|
| DOI: | 10.1007/82_2017_56 |