دورية أكاديمية
أعرض في EDS

Honokiol protects against doxorubicin cardiotoxicity via improving mitochondrial function in mouse hearts.

التفاصيل البيبلوغرافية
العنوان: Honokiol protects against doxorubicin cardiotoxicity via improving mitochondrial function in mouse hearts.
المؤلفون: Huang L; School of Basic Medicine, Research Center of Integrative Medicine, Guangzhou University of Chinese Medicine, 230 Guangzhou University City Outer Ring Road, Guangzhou, 510006, China.; Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave, Wuhan, 430030, China., Zhang K; Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave, Wuhan, 430030, China., Guo Y; Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave, Wuhan, 430030, China., Huang F; Department of Nutrition Sciences, University of Alabama at Birmingham, 1675 Univ Blvd, Birmingham, AL, 35205, USA., Yang K; Department of Nutrition Sciences, University of Alabama at Birmingham, 1675 Univ Blvd, Birmingham, AL, 35205, USA., Chen L; Department of Cardiovascular Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Ave, Wuhan, 430022, China., Huang K; Department of Cardiovascular Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Ave, Wuhan, 430022, China., Zhang F; School of Basic Medicine, Research Center of Integrative Medicine, Guangzhou University of Chinese Medicine, 230 Guangzhou University City Outer Ring Road, Guangzhou, 510006, China., Long Q; Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave, Wuhan, 430030, China. qqlong@tjh.tjmu.edu.cn., Yang Q; Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave, Wuhan, 430030, China. qyang@uab.edu.; Department of Nutrition Sciences, University of Alabama at Birmingham, 1675 Univ Blvd, Birmingham, AL, 35205, USA. qyang@uab.edu.
المصدر: Scientific reports [Sci Rep] 2017 Sep 20; Vol. 7 (1), pp. 11989. Date of Electronic Publication: 2017 Sep 20.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Anti-Arrhythmia Agents/*administration & dosage , Antibiotics, Antineoplastic/*adverse effects , Biphenyl Compounds/*administration & dosage , Cardiotoxicity/*prevention & control , Doxorubicin/*adverse effects , Heart/*drug effects , Lignans/*administration & dosage , Mitochondria/*drug effects, Animals ; Antibiotics, Antineoplastic/administration & dosage ; Cell Respiration/drug effects ; Doxorubicin/administration & dosage ; Mice, Inbred C57BL ; Oxygen/metabolism
مستخلص: Honokiol is a key component of a medicinal herb, Magnolia bark. Honokiol possesses potential pharmacological benefits for many disease conditions, especially cancer. Recent studies demonstrate that Honokiol exerts beneficial effects on cardiac hypertrophy and doxorubicin (Dox)-cardiotoxicity via deacetylation of mitochondrial proteins. However, the effects and mechanisms of Honokiol on cardiac mitochondrial respiration remain unclear. In the present study, we investigate the effect of Honokiol on cardiac mitochondrial respiration in mice subjected to Dox treatment. Oxygen consumption in freshly isolated mitochondria from mice treated with Honokiol showed enhanced mitochondrial respiration. The Dox-induced impairment of mitochondrial respiration was less pronounced in honokiol-treated than control mice. Furthermore, Luciferase reporter assay reveals that Honokiol modestly increased PPARγ transcriptional activities in cultured embryonic rat cardiomyocytes (H9c2). Honokiol upregulated the expression of PPARγ in the mouse heart. Honokiol repressed cardiac inflammatory responses and oxidative stress in mice subjected to Dox treatment. As a result, Honokiol alleviated Dox-cardiotoxicity with improved cardiac function and reduced cardiomyocyte apoptosis. We conclude that Honokiol protects the heart from Dox-cardiotoxicity via improving mitochondrial function by not only repressing mitochondrial protein acetylation but also enhancing PPARγ activity in the heart. This study further supports Honokiol as a promising therapy for cancer patients receiving Dox treatment.
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معلومات مُعتمدة: R01 HL135336 United States HL NHLBI NIH HHS; R03 AG055899 United States AG NIA NIH HHS
المشرفين على المادة: 0 (Anti-Arrhythmia Agents)
0 (Antibiotics, Antineoplastic)
0 (Biphenyl Compounds)
0 (Lignans)
11513CCO0N (honokiol)
80168379AG (Doxorubicin)
S88TT14065 (Oxygen)
تواريخ الأحداث: Date Created: 20170922 Date Completed: 20190701 Latest Revision: 20190701
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC5607346
DOI: 10.1038/s41598-017-12095-y
PMID: 28931882
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-017-12095-y