دورية أكاديمية
Survey of poliovirus antibodies in Borno and Yobe States, North-Eastern Nigeria.
| العنوان: | Survey of poliovirus antibodies in Borno and Yobe States, North-Eastern Nigeria. |
|---|---|
| المؤلفون: | Gofama MM; University of Maiduguri Teaching Hospital, Maiduguri, Nigeria., Verma H; World Health Organization, Geneva, Switzerland., Abdullahi H; World Health Organization, Abuja, Nigeria., Molodecky NA; World Health Organization, Geneva, Switzerland., Craig KT; World Health Organization, Abuja, Nigeria., Urua UA; National Primary Health Care Development Agency, Abuja, Nigeria., Garba MA; University of Maiduguri Teaching Hospital, Maiduguri, Nigeria., Alhaji MA; University of Maiduguri Teaching Hospital, Maiduguri, Nigeria., Weldon WC; Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America., Oberste MS; Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America., Braka F; World Health Organization, Abuja, Nigeria., Muhammad AJG; National Primary Health Care Development Agency, Abuja, Nigeria., Sutter RW; World Health Organization, Geneva, Switzerland. |
| المصدر: | PloS one [PLoS One] 2017 Sep 26; Vol. 12 (9), pp. e0185284. Date of Electronic Publication: 2017 Sep 26 (Print Publication: 2017). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: San Francisco, CA : Public Library of Science |
| مواضيع طبية MeSH: | Antibodies, Viral/*blood , Poliovirus/*immunology, Child ; Child, Preschool ; Female ; Humans ; Infant ; Male ; Nigeria |
| مستخلص: | Background: Nigeria remains one of only three polio-endemic countries in the world. In 2016, after an absence of 2 years, wild poliovirus serotype 1 was again detected in North-Eastern Nigeria. To better guide programmatic action, we assessed the immunity status of infants and children in Borno and Yobe states, and evaluated the impact of recently introduced inactivated poliovirus vaccine (IPV) on antibody seroprevalence. Methods and Findings: We conducted a facility-based study of seroprevalence to poliovirus serotypes 1, 2 and 3 among health-seeking patients in two sites each of Borno and Yobe States. Enrolment was conducted amongst children 6-9 and 36-47 months of age attending the paediatrics outpatient department of the selected hospitals in the two states between 11 January and 5 February 2016. Detailed demographic and immunization history of the child was taken and an assessment of the child's health and nutritional state was conducted via physical examination. Blood was collected to test for levels of neutralizing antibody titres against the three poliovirus serotypes. The seroprevalence in the two age groups, potential determinants of seropositivity and the impact of one dose of IPV on humoral immunity were assessed. A total of 583 subjects were enrolled and provided sufficient quantities of serum for testing. Among 6-9-month-old infants, the seroprevalence was 81% (74-87%), 86% (79-91%), and 72% (65-79%) in Borno State, and 75% (67-81%), 74% (66-81%) and 69% (61-76%) in Yobe States, for serotypes-1, 2 and 3, respectively. Among children aged 36-47 months, the seroprevalence was >90% in both states for all three serotypes, with the exception of type 3 seroprevalence in Borno [87% (80-91%)]. Median reciprocal anti-polio neutralizing antibody titers were consistently >900 for serotypes 1 and 2 across age groups and states; with lower estimates for serotype 3, particularly in Borno. IPV received in routine immunization was found to be a significant determinant of seropositivity and anti-polio neutralizing antibodies among 6-9-month-old infants for serotypes 1 and 3, but demonstrated a non-significant positive association for serotype 2. Children receiving IPV through SIAs demonstrated significantly higher anti-polio neutralizing antibodies for serotypes 1 and 3. Conclusions: The seroprevalence to poliovirus remains suboptimal in both Borno and Yobe States in Nigeria. The low seroprevalence facilitated the continued transmission of both wild serotype 1 and serotype 2 circulating vaccine-derived poliovirus detected in Borno State in 2016. Further efforts are necessary to improve the immunity status of these populations to ensure sufficient population immunity to interrupt transmission. |
| References: | Pak J Med Sci. 2015 Mar-Apr;31(2):403-7. (PMID: 26101500) Indian Pediatr. 2016 Aug 7;53 Suppl 1:S14-S19. (PMID: 27771634) Vaccine. 2012 Nov 6;30(48):6759-65. (PMID: 23000220) Lancet. 2010 Nov 13;376(9753):1682-8. (PMID: 20980048) J Infect Dis. 2014 Sep 15;210(6):853-64. (PMID: 24688069) Science. 2006 Nov 17;314(5802):1150-3. (PMID: 17110580) Vaccine. 2007 Jun 28;25(27):5062-70. (PMID: 17543428) Vaccine. 2014 Mar 10;32(12):1414-20. (PMID: 24041545) Lancet Infect Dis. 2012 Feb;12(2):128-35. (PMID: 22071249) Lancet Glob Health. 2014 Feb;2(2):e90-7. (PMID: 25104665) Science. 2017 Apr 7;356(6333):18-23. (PMID: 28385968) Methods Mol Biol. 2016;1387:145-76. (PMID: 26983734) MMWR Morb Mortal Wkly Rep. 2016 Aug 05;65(30):770-3. (PMID: 27490081) Vaccine. 2016 Sep 30;34(42):5125-5131. (PMID: 27591950) |
| معلومات مُعتمدة: | 001 International WHO_ World Health Organization |
| المشرفين على المادة: | 0 (Antibodies, Viral) |
| تواريخ الأحداث: | Date Created: 20170927 Date Completed: 20171031 Latest Revision: 20220129 |
| رمز التحديث: | 20240829 |
| مُعرف محوري في PubMed: | PMC5614605 |
| DOI: | 10.1371/journal.pone.0185284 |
| PMID: | 28949979 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1932-6203 |
|---|---|
| DOI: | 10.1371/journal.pone.0185284 |