دورية أكاديمية
أعرض في EDS

Making Sense of Multifunctional Proteins: Human Immunodeficiency Virus Type 1 Accessory and Regulatory Proteins and Connections to Transcription.

التفاصيل البيبلوغرافية
العنوان: Making Sense of Multifunctional Proteins: Human Immunodeficiency Virus Type 1 Accessory and Regulatory Proteins and Connections to Transcription.
المؤلفون: Faust TB; Department of Biochemistry and Biophysics, University of California, San Francisco, California 94158; email: tybifa@gmail.com , frankel@cgl.ucsf.edu., Binning JM; Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94158; email: jennifer.binning@ucsf.edu , jdgross@cgl.ucsf.edu., Gross JD; Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94158; email: jennifer.binning@ucsf.edu , jdgross@cgl.ucsf.edu., Frankel AD; Department of Biochemistry and Biophysics, University of California, San Francisco, California 94158; email: tybifa@gmail.com , frankel@cgl.ucsf.edu.
المصدر: Annual review of virology [Annu Rev Virol] 2017 Sep 29; Vol. 4 (1), pp. 241-260.
نوع المنشور: Journal Article; Review; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Annual Reviews Country of Publication: United States NLM ID: 101625721 Publication Model: Print Cited Medium: Internet ISSN: 2327-0578 (Electronic) Linking ISSN: 2327056X NLM ISO Abbreviation: Annu Rev Virol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Palo Alto, California : Annual Reviews, 2014-
مواضيع طبية MeSH: Genes, rev* , Genes, tat* , Transcription, Genetic*, HIV-1/*genetics , Human Immunodeficiency Virus Proteins/*metabolism , Viral Regulatory and Accessory Proteins/*metabolism, HIV-1/chemistry ; HIV-1/physiology ; Host-Pathogen Interactions ; Human Immunodeficiency Virus Proteins/genetics ; Humans ; Viral Regulatory and Accessory Proteins/genetics ; Virus Replication ; nef Gene Products, Human Immunodeficiency Virus/genetics ; nef Gene Products, Human Immunodeficiency Virus/metabolism ; vif Gene Products, Human Immunodeficiency Virus/genetics ; vif Gene Products, Human Immunodeficiency Virus/metabolism ; vpr Gene Products, Human Immunodeficiency Virus/genetics ; vpr Gene Products, Human Immunodeficiency Virus/metabolism
مستخلص: Viruses are completely dependent upon cellular machinery to support replication and have therefore developed strategies to co-opt cellular processes to optimize infection and counter host immune defenses. Many viruses, including human immunodeficiency virus type 1 (HIV-1), encode a relatively small number of genes. Viruses with limited genetic content often encode multifunctional proteins that function at multiple stages of the viral replication cycle. In this review, we discuss the functions of HIV-1 regulatory (Tat and Rev) and accessory (Vif, Vpr, Vpu, and Nef) proteins. Each of these proteins has a highly conserved primary activity; however, numerous additional activities have been attributed to these viral proteins. We explore the possibility that HIV-1 proteins leverage their multifunctional nature to alter host transcriptional networks to elicit a diverse set of cellular responses. Although these transcriptional effects appear to benefit the virus, it is not yet clear whether they are strongly selected for during viral evolution or are a ripple effect from the primary function. As our detailed knowledge of these viral proteins improves, we will undoubtedly uncover how the multifunctional nature of these HIV-1 regulatory and accessory proteins, and in particular their transcriptional functions, work to drive viral pathogenesis.
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معلومات مُعتمدة: T32 AI060537 United States AI NIAID NIH HHS; F32 AI120867 United States AI NIAID NIH HHS; P50 GM082250 United States GM NIGMS NIH HHS; T32 HD007470 United States HD NICHD NIH HHS; R01 GM078360 United States GM NIGMS NIH HHS
فهرسة مساهمة: Keywords: host-pathogen interactions; human immunodeficiency virus; multifunctional proteins; transcription; virus replication
المشرفين على المادة: 0 (Human Immunodeficiency Virus Proteins)
0 (Viral Regulatory and Accessory Proteins)
0 (nef Gene Products, Human Immunodeficiency Virus)
0 (vif Gene Products, Human Immunodeficiency Virus)
0 (vpr Gene Products, Human Immunodeficiency Virus)
0 (vpu protein, Human immunodeficiency virus 1)
تواريخ الأحداث: Date Created: 20170930 Date Completed: 20171027 Latest Revision: 20200626
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC5750048
DOI: 10.1146/annurev-virology-101416-041654
PMID: 28961413
قاعدة البيانات: MEDLINE
الوصف
تدمد:2327-0578
DOI:10.1146/annurev-virology-101416-041654