دورية أكاديمية
أعرض في EDS

Epidemiology of malignant cutaneous granular cell tumors: A US population-based cohort analysis using the Surveillance, Epidemiology, and End Results (SEER) database.

التفاصيل البيبلوغرافية
العنوان: Epidemiology of malignant cutaneous granular cell tumors: A US population-based cohort analysis using the Surveillance, Epidemiology, and End Results (SEER) database.
المؤلفون: Mirza FN; Yale School of Medicine, New Haven, Connecticut., Tuggle CT; Section of Plastic and Reconstructive Surgery, Department of Surgery, Yale School of Medicine, New Haven, Connecticut., Zogg CK; Yale School of Medicine, New Haven, Connecticut., Mirza HN; Columbia University, New York, New York., Narayan D; Section of Plastic and Reconstructive Surgery, Department of Surgery, Yale School of Medicine, New Haven, Connecticut. Electronic address: deepak.narayan@yale.edu.
المصدر: Journal of the American Academy of Dermatology [J Am Acad Dermatol] 2018 Mar; Vol. 78 (3), pp. 490-497.e1. Date of Electronic Publication: 2017 Oct 05.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Mosby Country of Publication: United States NLM ID: 7907132 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-6787 (Electronic) Linking ISSN: 01909622 NLM ISO Abbreviation: J Am Acad Dermatol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: St. Louis, Mo., Mosby
مواضيع طبية MeSH: Granular Cell Tumor/*epidemiology , Granular Cell Tumor/*pathology , Kidney Neoplasms/*epidemiology , Pancreatic Neoplasms/*epidemiology , Skin Neoplasms/*epidemiology , Skin Neoplasms/*pathology, Adolescent ; Adult ; Black or African American/statistics & numerical data ; Aged ; Aged, 80 and over ; Child ; Female ; Granular Cell Tumor/mortality ; Granular Cell Tumor/surgery ; Humans ; Incidence ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Neoplasm Staging ; Residence Characteristics ; Retrospective Studies ; SEER Program ; Sex Factors ; Skin Neoplasms/mortality ; Skin Neoplasms/surgery ; Survival Rate ; United States/epidemiology ; White People/statistics & numerical data ; Young Adult
مستخلص: Background: Malignant cutaneous granular cell tumors (mcGCTs) are rare and associated with substantial morbidity and mortality. The literature includes single-institution studies.
Objective: To examine the incidence, secondary malignancies, treatment, overall survival, and disease-specific survival (DSS) of patients with mcGCT.
Methods: A population-based cohort analysis was conducted in the Surveillance, Epidemiology, and End Results database from 1973 to 2013 for patients with a diagnosis of mcGCT. Risk-adjusted associations between overall survival/DSS and patient characteristics and treatment modalities were assessed by Cox proportional hazard regression. Quantile regression was used to determine median survival times.
Results: The 5-year DSS rate was 62.8%. Patients demonstrated an increased risk for renal and pancreatic cancers. In risk-adjusted models, male sex (hazard ratio [HR], 0.21; 95% confidence interval [CI], 0.06-0.82; P = .02), advanced cancer stage (HR, 2.29; 95% CI, 1.40-3.72; P < .01), and surgical resection (HR, 0.06; 95% CI, 0.01-0.59; P = .02) predicted DSS. Median survival time in years increased for males (1.39), earlier stage (0.60), and surgical intervention (5.34).
Limitations: Absent or incorrect reporting in retrospective Surveillance, Epidemiology, and End Results data is possible. The database is more likely to include academic centers. Some subanalyses may be underpowered because of the limited sample size for a rare cancer.
Conclusions: Our study presents an in-depth assessment of factors that identify high-risk patients. Residency in a nonmetro area, black race, female sex, and no surgical resection were each associated with poorer DSS.
(Copyright © 2017 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.)
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معلومات مُعتمدة: T32 GM007205 United States GM NIGMS NIH HHS; UL1 TR001863 United States TR NCATS NIH HHS
فهرسة مساهمة: Keywords: SEER; cutaneous malignancy; disparities; epidemiology; granular cell tumors; outcomes
تواريخ الأحداث: Date Created: 20171010 Date Completed: 20181012 Latest Revision: 20221207
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC5815907
DOI: 10.1016/j.jaad.2017.09.062
PMID: 28989104
قاعدة البيانات: MEDLINE
الوصف
تدمد:1097-6787
DOI:10.1016/j.jaad.2017.09.062