دورية أكاديمية
Polymorphisms in interleukins 17A and 17F genes and periodontitis: results from a meta-analysis.
العنوان: | Polymorphisms in interleukins 17A and 17F genes and periodontitis: results from a meta-analysis. |
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المؤلفون: | da Silva FRP; Laboratory of Histological Analysis and Preparation (LAPHIS), Federal University of Piaui, Parnaiba, PI, Brazil., Pessoa LDS; Laboratory of Histological Analysis and Preparation (LAPHIS), Federal University of Piaui, Parnaiba, PI, Brazil., Vasconcelos ACCG; Laboratory of Histological Analysis and Preparation (LAPHIS), Federal University of Piaui, Parnaiba, PI, Brazil.; Medicine School, Education Institute of Parnaiba Valley (IESVAP), Parnaiba, PI, Brazil., de Aquino Lima W; Federal University of Rio Grande do Norte, Currais Novos, RN, Brazil., Alves EHP; Laboratory of Histological Analysis and Preparation (LAPHIS), Federal University of Piaui, Parnaiba, PI, Brazil., Vasconcelos DFP; Laboratory of Histological Analysis and Preparation (LAPHIS), Federal University of Piaui, Parnaiba, PI, Brazil. vasconcelos@ufpi.edu.br.; Universidade Federal do Piauí - UFPI, Campus Ministro Reis Veloso, Colegiado de Biomedicina, Av. São Sebastião, 2819, Reis Veloso, Parnaiba, PI, 64204-035, Brazil. vasconcelos@ufpi.edu.br. |
المصدر: | Molecular biology reports [Mol Biol Rep] 2017 Dec; Vol. 44 (6), pp. 443-453. Date of Electronic Publication: 2017 Oct 13. |
نوع المنشور: | Journal Article; Meta-Analysis; Review |
اللغة: | English |
بيانات الدورية: | Publisher: Reidel Country of Publication: Netherlands NLM ID: 0403234 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-4978 (Electronic) Linking ISSN: 03014851 NLM ISO Abbreviation: Mol Biol Rep Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Dordrecht, Boston, Reidel. |
مواضيع طبية MeSH: | Interleukin-17/*genetics , Periodontitis/*genetics, Adult ; Alleles ; Case-Control Studies ; Gene Frequency/genetics ; Genetic Predisposition to Disease/genetics ; Humans ; Interleukin-17/metabolism ; Odds Ratio ; Polymorphism, Single Nucleotide/genetics ; Risk Factors |
مستخلص: | Polymorphisms in inflammatory genes such as interleukins 17A and 17F are associated with the risk of development of periodontitis, although the results remain contradictory. Hence, the aim of this study was perform a meta-analysis focusing on two polymorphisms (rs2275913 and rs763780) in interleukins 17A and 17F genes, respectively, in both chronic (CP) and aggressive periodontitis (AgP). A review in literature was performed in several databases for studies published before 25, September 2016. The meta-analysis was obtained through the review manager statistical software (version 5.2) with odds ratio (OR) calculation and funnel plot (P < 0.05) for heterogeneity, as well as the comprehensive meta-analysis software (version 3.3.070) for the assessment of publication bias. Seven articles with 1540 participants composed the results in which the mutant allele in the rs2275913 polymorphism did not present significant association with the risk of CP or AgP (OR 1.56, 95% CI 0.77, 3.15, P = 0.21; OR 1.12, 95% CI 0.05, 23.44, P = 0.94, respectively) nor was the mutant allele in rs763780 associated with the risk of CP (OR 1.19, 95% CI 0.80, 1.76, P = 0.39) or AgP (OR 1.07, 95% CI 0.63, 1.84, P = 0.79). No bias of publication was observed by Egger's and Begg's tests in any allelic evaluation. This meta-analysis showed a non-significant association between the polymorphisms rs2275913 and rs763780 in interleukins 17A and 17F genes and chronic and aggressive periodontitis in the allelic evaluation. |
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فهرسة مساهمة: | Keywords: Aggressive periodontitis; Chronic periodontitis; Cytokines; Genetic; Genomics; Risk factors |
المشرفين على المادة: | 0 (IL17A protein, human) 0 (IL17F protein, human) 0 (Interleukin-17) |
تواريخ الأحداث: | Date Created: 20171014 Date Completed: 20180102 Latest Revision: 20181113 |
رمز التحديث: | 20231215 |
DOI: | 10.1007/s11033-017-4128-x |
PMID: | 29027636 |
قاعدة البيانات: | MEDLINE |
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