دورية أكاديمية
أعرض في EDS

Pharmacological targeting of exercise adaptations in skeletal muscle: Benefits and pitfalls.

التفاصيل البيبلوغرافية
العنوان: Pharmacological targeting of exercise adaptations in skeletal muscle: Benefits and pitfalls.
المؤلفون: Weihrauch M; Biozentrum, University of Basel, Basel, Switzerland., Handschin C; Biozentrum, University of Basel, Basel, Switzerland. Electronic address: christoph.handschin@unibas.ch.
المصدر: Biochemical pharmacology [Biochem Pharmacol] 2018 Jan; Vol. 147, pp. 211-220. Date of Electronic Publication: 2017 Oct 20.
نوع المنشور: Journal Article; Review; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE
أسماء مطبوعة: Publication: Oxford : Elsevier Science
Original Publication: Oxford, New York [etc.] Paragamon Press.
مواضيع طبية MeSH: Biomimetics*/methods, Adaptation, Physiological/*physiology , Drug Delivery Systems/*methods , Exercise/*physiology , Muscle, Skeletal/*physiology, Adaptation, Physiological/drug effects ; Animals ; Humans ; Muscle, Skeletal/drug effects ; Muscular Atrophy/drug therapy ; Muscular Atrophy/physiopathology
مستخلص: Exercise exerts significant effects on the prevention and treatment of many diseases. However, even though some of the key regulators of training adaptation in skeletal muscle have been identified, this biological program is still poorly understood. Accordingly, exercise-based pharmacological interventions for many muscle wasting diseases and also for pathologies that are triggered by a sedentary lifestyle remain scarce. The most efficacious compounds that induce muscle hypertrophy or endurance are hampered by severe side effects and are classified as doping. In contrast, dietary supplements with a higher safety margin exert milder outcomes. In recent years, the design of pharmacological agents that activate the training program, so-called "exercise mimetics", has been proposed, although the feasibility of such an approach is highly debated. In this review, the most recent insights into key regulatory factors and therapeutic approaches aimed at leveraging exercise adaptations are discussed.
(Copyright © 2017 Elsevier Inc. All rights reserved.)
References: Am J Pathol. 2006 Oct;169(4):1129-39. (PMID: 17003473)
J Appl Physiol (1985). 2011 Nov;111(5):1335-44. (PMID: 21836044)
Recept Channels. 1994;2(2):165-74. (PMID: 7953292)
Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19926-31. (PMID: 19066218)
J Strength Cond Res. 2016 Sep;30(9):2638-47. (PMID: 26808848)
Skelet Muscle. 2016 Dec 2;6(1):39. (PMID: 27908291)
Arzneimittelforschung. 1991 Jun;41(6):660-3. (PMID: 1930358)
Hum Mol Genet. 2009 Dec 1;18(23):4640-9. (PMID: 19744959)
Trends Pharmacol Sci. 2009 Jun;30(6):322-9. (PMID: 19446346)
FASEB J. 2002 Dec;16(14):1879-86. (PMID: 12468452)
Physiol Genomics. 2008 Jan 17;32(2):219-28. (PMID: 17957000)
Cell. 2012 Apr 13;149(2):274-93. (PMID: 22500797)
Nature. 2008 Jul 24;454(7203):463-9. (PMID: 18650917)
Diabetes. 2013 Jan;62(1):85-95. (PMID: 23086035)
Bone. 2015 Nov;80:115-125. (PMID: 26453501)
J Clin Invest. 2000 Oct;106(7):847-56. (PMID: 11018072)
J Physiol. 2003 Feb 1;546(Pt 3):851-8. (PMID: 12563009)
Med Sci Sports Exerc. 2001 Dec;33(12):2111-7. (PMID: 11740307)
Cell Metab. 2017 May 2;25(5):1186-1193.e4. (PMID: 28467934)
Neurology. 2004 May 25;62(10):1771-7. (PMID: 15159476)
Life Sci. 2004 Sep 3;75(16):1917-24. (PMID: 15306159)
Nutrition. 2004 May;20(5):445-51. (PMID: 15105032)
J Biol Chem. 1995 Jul 21;270(29):17513-20. (PMID: 7615556)
Med Sci Sports Exerc. 1999 Aug;31(8):1147-56. (PMID: 10449017)
Science. 2017 Aug 4;357(6350):507-511. (PMID: 28705990)
Clin Investig. 1994;72(6 Suppl):S36-43. (PMID: 7950171)
Front Physiol. 2015 Nov 09;6:325. (PMID: 26617528)
Expert Opin Pharmacother. 2014 Mar;15(4):493-503. (PMID: 24428677)
J Strength Cond Res. 2003 Nov;17(4):822-31. (PMID: 14636102)
Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8466-71. (PMID: 12832613)
J Cachexia Sarcopenia Muscle. 2017 Aug;8(4):529-541. (PMID: 28493406)
Mol Genet Metab. 2012 Apr;105(4):607-14. (PMID: 22325939)
N Engl J Med. 1990 Jan 25;322(4):223-8. (PMID: 2403659)
Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):15983-7. (PMID: 12444247)
JPEN J Parenter Enteral Nutr. 2011 Nov;35(6):757-62. (PMID: 21807930)
J Int Soc Sports Nutr. 2016 Feb 19;13:6. (PMID: 26900386)
Med Sci Sports Exerc. 2010 Oct;42(10):1951-8. (PMID: 20195181)
Prog Lipid Res. 2006 Mar;45(2):120-59. (PMID: 16476485)
Amino Acids. 2013 Dec;45(6):1273-92. (PMID: 24057808)
Am J Physiol Endocrinol Metab. 2003 Nov;285(5):E1089-94. (PMID: 12824083)
Sci Rep. 2016 Aug 09;6:31142. (PMID: 27502839)
Muscle Nerve. 2003 May;27(5):604-10. (PMID: 12707981)
Biochimie. 2017 May;136:49-54. (PMID: 28057584)
Cell Metab. 2013 Feb 5;17(2):162-84. (PMID: 23395166)
Sports Med. 2015 Oct;45(10):1469-81. (PMID: 26243014)
Med Sci Sports Exerc. 2011 May;43(5):770-8. (PMID: 20881878)
Nature. 2001 Sep 13;413(6852):131-8. (PMID: 11557972)
Cell. 1998 Mar 20;92(6):829-39. (PMID: 9529258)
Eur Heart J. 1996 Oct;17(10):1576-83. (PMID: 8909917)
Nature. 2002 Aug 15;418(6899):797-801. (PMID: 12181572)
Cell. 2008 Aug 8;134(3):405-15. (PMID: 18674809)
J Physiol. 2009 Dec 1;587(Pt 23):5527-39. (PMID: 19723782)
J Strength Cond Res. 2010 May;24(5):1215-22. (PMID: 20386132)
Neurol Clin. 2014 Aug;32(3):671-88, viii. (PMID: 25037084)
Eur J Biochem. 1997 Jun 1;246(2):259-73. (PMID: 9208914)
J Physiol. 2017 May 1;595(9):2915-2930. (PMID: 27748956)
Diabetologia. 2014 Nov;57(11):2405-12. (PMID: 25116175)
Mol Genet Metab. 2016 Apr;117(4):407-12. (PMID: 26851065)
Dev Cell. 2003 Jul;5(1):73-83. (PMID: 12852853)
Nat Genet. 2003 Jul;34(3):267-73. (PMID: 12808457)
Clin Sci (Lond). 2004 Jan;106(1):99-106. (PMID: 14507259)
Aging (Albany NY). 2017 Sep 1;9(9):1941-1942. (PMID: 28876223)
Cell. 2017 Mar 23;169(1):148-160.e15. (PMID: 28340340)
J Athl Train. 2003 Mar;38(1):44-50. (PMID: 12937471)
J Clin Invest. 2006 Mar;116(3):615-22. (PMID: 16511594)
J Physiol. 2017 Jul 15;595(14):4845-4855. (PMID: 28464351)
Biosci Biotechnol Biochem. 2007 Jul;71(7):1650-6. (PMID: 17617726)
Circ Res. 2004 Mar 5;94(4):525-33. (PMID: 14726475)
Nat Rev Endocrinol. 2011 Nov 08;8(4):228-36. (PMID: 22064493)
Diabetes. 2001 Jan;50(1):18-23. (PMID: 11147785)
Amino Acids. 2010 Jan;38(1):31-44. (PMID: 19253023)
Br J Sports Med. 2002 Aug;36(4):282-9. (PMID: 12145119)
J Physiol. 2017 May 1;595(9):2883-2896. (PMID: 27506998)
EMBO J. 2007 Apr 4;26(7):1913-23. (PMID: 17347648)
Cell Metab. 2014 Mar 4;19(3):373-9. (PMID: 24508508)
Biochem J. 1939 Jun;33(6):902-7. (PMID: 16746990)
J Nutr Sci Vitaminol (Tokyo). 2011;57(3):246-50. (PMID: 21908948)
Diabetes. 2000 Apr;49(4):527-31. (PMID: 10871188)
Nature. 2007 Nov 29;450(7170):736-40. (PMID: 18046414)
Neuromuscul Disord. 2002 Feb;12(2):174-82. (PMID: 11738360)
Cell Metab. 2013 May 7;17(5):731-44. (PMID: 23602450)
Cell. 2006 Aug 25;126(4):801-10. (PMID: 16923398)
Cell Metab. 2006 Nov;4(5):407-14. (PMID: 17084713)
Am J Physiol Endocrinol Metab. 2017 Apr 1;312(4):E282-E299. (PMID: 28143855)
J Appl Physiol (1985). 2000 Oct;89(4):1340-4. (PMID: 11007567)
Biochem J. 1992 Jan 1;281 ( Pt 1):21-40. (PMID: 1731757)
Sports Med. 2004;34(8):513-54. (PMID: 15248788)
Mol Genet Metab. 2015 Sep-Oct;116(1-2):4-12. (PMID: 26095523)
Br J Nutr. 2013 Aug 28;110(3):538-44. (PMID: 23286834)
J Appl Physiol Respir Environ Exerc Physiol. 1982 Oct;53(4):844-50. (PMID: 6295989)
J Strength Cond Res. 2009 May;23(3):827-35. (PMID: 19387396)
J Nutr Health Aging. 2005 Sep-Oct;9(5):352-3. (PMID: 16222402)
Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2613-8. (PMID: 11867749)
Cell Metab. 2008 Nov;8(5):411-24. (PMID: 19046572)
Magn Reson Imaging. 2010 Jun;28(5):698-707. (PMID: 20395096)
معلومات مُعتمدة: 616830 International ERC_ European Research Council
فهرسة مساهمة: Keywords: AICAR (PubChem CID 266934); AMPK; Citrulline malate (PubChem CID 162762); Cpd14 (PubChem CID not available); Creatine (PubChem CID 586); Dietary supplements; Exercise; Exercise mimetics; GW501516 (PubChem CID 9803963); L-citrulline (PubChem CID 9750); MK-8722 (PubChem CID not available); Metformin (PubChem CID 4091); PF-739 (PubChem CID not available); PGC-1α; PPARβ/δ; R419 (PubChem CID not available); Rapamycin (PubChem CID 5284616); SR-18292 (PubChem CID not available); Scriptaid (PubChem CID 5186); Skeletal muscle; mTOR; β-Hydroxy β-methylbutyric acid (HMB) (PubChem CID 69362)
تواريخ الأحداث: Date Created: 20171025 Date Completed: 20180101 Latest Revision: 20240318
رمز التحديث: 20240318
مُعرف محوري في PubMed: PMC5850978
DOI: 10.1016/j.bcp.2017.10.006
PMID: 29061342
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-2968
DOI:10.1016/j.bcp.2017.10.006