دورية أكاديمية
Low-molecular-weight compounds with anticoagulant activity from the scorpion Heterometrus laoticus venom.
| العنوان: | Low-molecular-weight compounds with anticoagulant activity from the scorpion Heterometrus laoticus venom. |
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| المؤلفون: | Thien TV; Institute of Applied Materials Science, Vietnam Academy of Science and Technology, Ho Chi Minh City, Vietnam.; Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Ho Chi Minh City, Vietnam., Anh HN; Institute of Applied Materials Science, Vietnam Academy of Science and Technology, Ho Chi Minh City, Vietnam., Trang NTT; Faculty of Pharmacy, Nguyen Tat Thanh University, Ho Chi Minh City, Vietnam., Trung PV; Istitute of Chemical Technology, Vietnam Academy of Science and Technology, Ho Chi Minh City, Vietnam., Khoa NC; Institute of Applied Materials Science, Vietnam Academy of Science and Technology, Ho Chi Minh City, Vietnam., Osipov AV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia., Dubovskii PV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia., Ivanov IA; Istitute of Chemical Technology, Vietnam Academy of Science and Technology, Ho Chi Minh City, Vietnam., Arseniev AS; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia., Tsetlin VI; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia., Utkin YN; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia. utkin@mx.ibch.ru. |
| المصدر: | Doklady. Biochemistry and biophysics [Dokl Biochem Biophys] 2017 Sep; Vol. 476 (1), pp. 316-319. Date of Electronic Publication: 2017 Nov 04. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Pleiades Publishing Country of Publication: United States NLM ID: 101126895 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1608-3091 (Electronic) Linking ISSN: 16076729 NLM ISO Abbreviation: Dokl Biochem Biophys Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York, NY : Pleiades Publishing Original Publication: Moscow, Russia : [Dordrecht] : International Academic Pub. Co. "Nauka/Interperiodica" ; Distributed worldwide by Kluwer Academic/Plenum Publishers, c2001- |
| مواضيع طبية MeSH: | Scorpions*, Anticoagulants/*chemistry , Anticoagulants/*pharmacology , Scorpion Venoms/*chemistry, Animals ; Mice ; Molecular Weight |
| مستخلص: | Low-molecular-weight compounds with anticoagulant activity were isolated from the scorpion Heterometrus laoticus venom. The determination of the structure of the isolated compounds by nuclear magnetic resonance and mass spectrometry showed that one of the isolated compounds is adenosine, and the other two are dipeptides leucyl-tryptophan and isoleucyl-tryptophan. The anticoagulant properties of adenosine, which is an inhibitor of platelet aggregation, is well known, but its presence in scorpion venom is shown for the first time. The ability of leucyl-tryptophan and isoleucyl-tryptophan to slow down blood clotting and their presence in scorpion venom are also established for the first time. |
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| المشرفين على المادة: | 0 (Anticoagulants) 0 (Scorpion Venoms) |
| تواريخ الأحداث: | Date Created: 20171105 Date Completed: 20171116 Latest Revision: 20181113 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1134/S1607672917050052 |
| PMID: | 29101740 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1608-3091 |
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| DOI: | 10.1134/S1607672917050052 |