دورية أكاديمية
Evaluation of a polyvalent foot-and-mouth disease virus vaccine containing A Saudi-95 against field challenge on large-scale dairy farms in Saudi Arabia with the emerging A/ASIA/G-VII viral lineage.
| العنوان: | Evaluation of a polyvalent foot-and-mouth disease virus vaccine containing A Saudi-95 against field challenge on large-scale dairy farms in Saudi Arabia with the emerging A/ASIA/G-VII viral lineage. |
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| المؤلفون: | Lyons NA; The Pirbright Institute, Ash Road, Pirbright, Woking GU24 0NF, UK; European Commission for the Control of Foot-and-Mouth Disease (EuFMD), Food and Agriculture Organisation of the United Nations, Rome, Italy. Electronic address: nick.lyons@pirbright.ac.uk., Ludi AB; The Pirbright Institute, Ash Road, Pirbright, Woking GU24 0NF, UK., Wilsden G; The Pirbright Institute, Ash Road, Pirbright, Woking GU24 0NF, UK., Hamblin P; The Pirbright Institute, Ash Road, Pirbright, Woking GU24 0NF, UK., Qasim IA; Directorate of Animal Resources Services, Ministry of Environment, Water and Agriculture, Saudi Arabia., Gubbins S; The Pirbright Institute, Ash Road, Pirbright, Woking GU24 0NF, UK., King DP; The Pirbright Institute, Ash Road, Pirbright, Woking GU24 0NF, UK. |
| المصدر: | Vaccine [Vaccine] 2017 Dec 14; Vol. 35 (49 Pt B), pp. 6850-6857. Date of Electronic Publication: 2017 Nov 03. |
| نوع المنشور: | Evaluation Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8406899 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2518 (Electronic) Linking ISSN: 0264410X NLM ISO Abbreviation: Vaccine Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam, The Netherlands : Elsevier Science Original Publication: [Guildford, Surrey, UK] : Butterworths, [c1983- |
| مواضيع طبية MeSH: | Foot-and-Mouth Disease/*prevention & control , Foot-and-Mouth Disease Virus/*genetics , Vaccination/*veterinary , Viral Vaccines/*immunology, Animals ; Antibodies, Viral/blood ; Cattle ; Cattle Diseases/prevention & control ; Disease Outbreaks/prevention & control ; Disease Outbreaks/statistics & numerical data ; Disease Outbreaks/veterinary ; Farms ; Foot-and-Mouth Disease/epidemiology ; Foot-and-Mouth Disease/immunology ; Foot-and-Mouth Disease/virology ; Foot-and-Mouth Disease Virus/immunology ; Foot-and-Mouth Disease Virus/isolation & purification ; Immunization Schedule ; Incidence ; Neutralization Tests ; Saudi Arabia/epidemiology |
| مستخلص: | In 2015, foot-and-mouth disease (FMD) viruses of the A/ASIA/G-VII lineage emerged from the Indian sub-continent to cause outbreaks in the Middle and Near East. A factor which has been proposed to have contributed to the rapid spread of this lineage is the poor in vitro vaccine-match of field isolates to vaccine strains that are commonly used in the region. This study used data from outbreaks on four large-scale dairy farms using routine vaccination in Saudi Arabia, to evaluate the impact of vaccination and learn how to manage outbreaks more effectively in this setting. This evaluation also included an assessment of vaccine-induced neutralisation titres to the vaccine and field strains on a related farm with no history of FMD that employed an identical vaccination schedule. The incidence risk among exposed groups ranged from 2.6 to 20.1% and was significantly higher among youngstock (18.7%) compared to adults (7.4%). Evidence was found that local isolation of individual sick animals was more effective than whole group isolation and that subclinical infection and undetected circulation may occur on large-scale farms in Saudi Arabia, although both of these points require further evaluation. On the unaffected farm, the mean reciprocal titres for the vaccine and field strains were all above the cut-off supposed to correlate with clinical protection based on evidence from challenge studies. An estimate of vaccination effectiveness was not possible on the affected farms, but the incidence of FMD provides a more realistic estimation of the expected vaccine performance than in vivo studies or r (Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.) |
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| معلومات مُعتمدة: | BBS/E/I/00007036 United Kingdom BB_ Biotechnology and Biological Sciences Research Council; BBS/E/I/00007037 United Kingdom BB_ Biotechnology and Biological Sciences Research Council; BB/E/I/00001702 United Kingdom BB_ Biotechnology and Biological Sciences Research Council; BB/E/I/00007004 United Kingdom BB_ Biotechnology and Biological Sciences Research Council |
| فهرسة مساهمة: | Keywords: Correlates of protection; Foot-and-mouth disease; Vaccine evaluation; Vaccines |
| المشرفين على المادة: | 0 (Antibodies, Viral) 0 (Viral Vaccines) |
| تواريخ الأحداث: | Date Created: 20171108 Date Completed: 20180731 Latest Revision: 20231115 |
| رمز التحديث: | 20240829 |
| مُعرف محوري في PubMed: | PMC5723706 |
| DOI: | 10.1016/j.vaccine.2017.10.029 |
| PMID: | 29108665 |
| قاعدة البيانات: | MEDLINE |
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