دورية أكاديمية
Circadian Potassium Excretion is Unaffected Following Furosemide Induced Increase in Sodium Delivery to the Distal Nephron.
| العنوان: | Circadian Potassium Excretion is Unaffected Following Furosemide Induced Increase in Sodium Delivery to the Distal Nephron. |
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| المؤلفون: | Ilenwabor BP; Department of Physiology, School of Basic Medical Sciences, University of Benin, Benin City, Edo State. barnabas.ilenwabor@uniben.edu., Asowata EO, Obika LF |
| المصدر: | Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria [Niger J Physiol Sci] 2017 Jun 30; Vol. 32 (1), pp. 1-6. Date of Electronic Publication: 2017 Jun 30. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Physiological Society of Nigeria Country of Publication: Nigeria NLM ID: 8811109 Publication Model: Electronic Cited Medium: Internet ISSN: 0794-859X (Print) Linking ISSN: 0794859X NLM ISO Abbreviation: Niger J Physiol Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Benin City, Nigeria : Physiological Society of Nigeria |
| مواضيع طبية MeSH: | Circadian Rhythm/*physiology , Furosemide/*pharmacology , Nephrons/*drug effects , Potassium/*metabolism , Sodium/*metabolism, Aldosterone/metabolism ; Humans ; Male ; Nephrons/metabolism |
| مستخلص: | The mineralocorticoid aldosterone is widely accepted as a key regulator of K+ balance as well as urinary K+excretion. However, recent evidence suggests that the circadian control of K+ excretion is independent of aldosterone. Thedelivery of Na+ to the distal nephron is known to be an important determinant of aldosterone mediated secretion of K+ in thissegment of the nephron. Examining the link between distal Na+ delivery and K+ excretion; and how this link affect circadianK+ excretion will advance what is currently known about the maintenance of K+ homeostasis. In the current study, weinvestigated the effect of furosemide-induced increase in distal tubular Na+ on K+ excretion. Na+, K+ and aldosterone levelswere measured in 12-hour day time and 12-hour night time urine samples following furosemide administration, andcompared with controls in 10 apparently healthy male subjects. To confirm the increased delivery of Na+ to the distal nephronby furosemide, increased Na+ excretion and aldosterone activity was observed in subjects administered furosemide.Consistent with previous reports, night time K+ excretion was significantly lower than day time, and this observation wasunchanged even with increased Na+ delivery to the distal tubules. In healthy individuals, aldosterone increases K+ secretionand this is known to further increase with increased Na+ delivery to the potassium secreting segment of the nephron. Eventhough the administration of furosemide increased aldosterone activity and the delivery of Na+ to the distal tubules, the dipin night time K+ excretion was unchanged. Our findings suggest that the circadian control of K+ excretion is not linked toNa+ levels and thus independent of aldosterone. |
| المشرفين على المادة: | 4964P6T9RB (Aldosterone) 7LXU5N7ZO5 (Furosemide) 9NEZ333N27 (Sodium) RWP5GA015D (Potassium) |
| تواريخ الأحداث: | Date Created: 20171115 Date Completed: 20180802 Latest Revision: 20180802 |
| رمز التحديث: | 20231215 |
| PMID: | 29134970 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0794-859X |
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