دورية أكاديمية
Is there a role for combination anti-remodelling therapy for heart failure secondary to chronic rheumatic mitral regurgitation?
العنوان: | Is there a role for combination anti-remodelling therapy for heart failure secondary to chronic rheumatic mitral regurgitation? |
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المؤلفون: | Meel R; Division of Cardiology, Chris Hani Baragwanath Academic Hospital and University of the Witwatersrand, Johannesburg, South Africa. Email: ruchikameel@gmail.com., Peters F; Division of Cardiology, Chris Hani Baragwanath Academic Hospital and University of the Witwatersrand, Johannesburg, South Africa., Libhaber E; Division of Cardiology, Chris Hani Baragwanath Academic Hospital and University of the Witwatersrand, Johannesburg, South Africa., Essop MR; Division of Cardiology, Chris Hani Baragwanath Academic Hospital and University of the Witwatersrand, Johannesburg, South Africa. |
المصدر: | Cardiovascular journal of Africa [Cardiovasc J Afr] 2017 Sep/Oct; Vol. 28 (5), pp. 280-284. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Clinics Cardive Pub Country of Publication: South Africa NLM ID: 101313864 Publication Model: Print Cited Medium: Internet ISSN: 1680-0745 (Electronic) Linking ISSN: 10159657 NLM ISO Abbreviation: Cardiovasc J Afr Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Durbanville : Clinics Cardive Pub. |
مواضيع طبية MeSH: | Heart Failure/*drug therapy , Mitral Valve Insufficiency/*physiopathology , Ventricular Function, Left/*drug effects , Ventricular Remodeling/*drug effects, Adult ; Aged ; Echocardiography/methods ; Female ; Heart Atria/drug effects ; Heart Atria/physiopathology ; Humans ; Male ; Middle Aged ; Mitral Valve Insufficiency/drug therapy ; Prospective Studies |
مستخلص: | Introduction: The value of combination anti-remodelling therapy for heart failure (HF) secondary to mitral regurgitation (MR) is unknown. We studied the effect of anti-remodelling therapy on clinical and echocardiographic parameters in patients with severe chronic rheumatic mitral regurgitation (CRMR) presenting in HF. Methods: Thirty-one patients (29 females) at Chris Hani Baragwanath Academic Hospital, treated with combination therapy for HF due to CRMR and New York Heart Association functional class II-III symptoms, underwent prospective six-month follow up. Results: Mean age was 50.7 ± 8.5 years. No patients died or were hospitalised for HF during the study period. No worsening of clinical symptoms or functional status, or left and right ventricular echocardiographic parameters (p > 0.05) was noted. Peak left atrial systolic strain improved at six months (18.7 ± 7.7 vs 23.6 ± 8.5%, p = 0.02). Conclusion: This preliminary analysis suggests that combination anti-remodelling therapy may be beneficial for HF secondary to CRMR. We had no HF-related admissions or deaths, and no deterioration in echocardiographic parameters of ventricular size and function. |
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تواريخ الأحداث: | Date Created: 20171117 Date Completed: 20180726 Latest Revision: 20181113 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC5730678 |
DOI: | 10.5830/CVJA-2016-095 |
PMID: | 29144532 |
قاعدة البيانات: | MEDLINE |
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