دورية أكاديمية
Skeletal muscle overexpression of nicotinamide phosphoribosyl transferase in mice coupled with voluntary exercise augments exercise endurance.
| العنوان: | Skeletal muscle overexpression of nicotinamide phosphoribosyl transferase in mice coupled with voluntary exercise augments exercise endurance. |
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| المؤلفون: | Costford SR; Sanford-Burnham-Prebys Medical Discovery Institute, Orlando, FL, USA; Pennington Biomedical Research Center, Baton Rouge, LA, USA., Brouwers B; Translational Research Institute for Metabolism and Diabetes, Orlando, FL, USA., Hopf ME; Sanford-Burnham-Prebys Medical Discovery Institute, Orlando, FL, USA., Sparks LM; Sanford-Burnham-Prebys Medical Discovery Institute, Orlando, FL, USA; Translational Research Institute for Metabolism and Diabetes, Orlando, FL, USA., Dispagna M; Sanford-Burnham-Prebys Medical Discovery Institute, Orlando, FL, USA., Gomes AP; Harvard Medical School, Boston, MA, USA., Cornnell HH; Translational Research Institute for Metabolism and Diabetes, Orlando, FL, USA., Petucci C; Sanford-Burnham-Prebys Medical Discovery Institute, Orlando, FL, USA., Phelan P; Sanford-Burnham-Prebys Medical Discovery Institute, Orlando, FL, USA., Xie H; Pennington Biomedical Research Center, Baton Rouge, LA, USA; Translational Research Institute for Metabolism and Diabetes, Orlando, FL, USA., Yi F; Translational Research Institute for Metabolism and Diabetes, Orlando, FL, USA., Walter GA; University of Florida, Gainesville, FL, USA., Osborne TF; Sanford-Burnham-Prebys Medical Discovery Institute, Orlando, FL, USA., Sinclair DA; Harvard Medical School, Boston, MA, USA., Mynatt RL; Pennington Biomedical Research Center, Baton Rouge, LA, USA., Ayala JE; Sanford-Burnham-Prebys Medical Discovery Institute, Orlando, FL, USA., Gardell SJ; Sanford-Burnham-Prebys Medical Discovery Institute, Orlando, FL, USA., Smith SR; Sanford-Burnham-Prebys Medical Discovery Institute, Orlando, FL, USA; Pennington Biomedical Research Center, Baton Rouge, LA, USA; Translational Research Institute for Metabolism and Diabetes, Orlando, FL, USA. Electronic address: Steven.R.Smith.MD@flhosp.org. |
| المصدر: | Molecular metabolism [Mol Metab] 2018 Jan; Vol. 7, pp. 1-11. Date of Electronic Publication: 2017 Nov 06. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier GmbH Country of Publication: Germany NLM ID: 101605730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2212-8778 (Electronic) Linking ISSN: 22128778 NLM ISO Abbreviation: Mol Metab Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [München] : Elsevier GmbH, 2012- |
| مواضيع طبية MeSH: | Oxygen Consumption* , Physical Conditioning, Animal*, Cytokines/*metabolism , Muscle, Skeletal/*metabolism , Nicotinamide Phosphoribosyltransferase/*metabolism, Animals ; Cytokines/genetics ; Diet, High-Fat ; Mice ; Mice, Inbred C57BL ; Mitochondria/metabolism ; Muscle, Skeletal/physiology ; NAD/metabolism ; Nicotinamide Phosphoribosyltransferase/genetics |
| مستخلص: | Objective: Nicotinamide phosphoribosyl transferase (NAMPT) is the rate-limiting enzyme in the salvage pathway that produces nicotinamide adenine dinucleotide (NAD + ), an essential co-substrate regulating a myriad of signaling pathways. We produced a mouse that overexpressed NAMPT in skeletal muscle (NamptTg) and hypothesized that NamptTg mice would have increased oxidative capacity, endurance performance, and mitochondrial gene expression, and would be rescued from metabolic abnormalities that developed with high fat diet (HFD) feeding. Methods: Insulin sensitivity (hyperinsulinemic-euglycemic clamp) was assessed in NamptTg and WT mice fed very high fat diet (VHFD, 60% by kcal) or chow diet (CD). The aerobic capacity (VO Results: NAMPT enzyme activity in skeletal muscle was 7-fold higher in NamptTg mice versus WT mice. There was a concomitant 1.6-fold elevation of skeletal muscle NAD + . NamptTg mice fed VHFD were partially protected against body weight gain, but not against insulin resistance. Notably, voluntary exercise training elicited a 3-fold higher exercise endurance in NamptTg versus WT mice. Mitochondrial gene expression was higher in NamptTg mice compared to WT mice, especially when fed HFD. Mitochondrial gene expression was higher in exercised NamptTg mice than in sedentary WT mice. Conclusions: Our studies have unveiled a fascinating interaction between elevated NAMPT activity in skeletal muscle and voluntary exercise that was manifest as a striking improvement in exercise endurance. (Copyright © 2017 The Authors. Published by Elsevier GmbH.. All rights reserved.) |
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| معلومات مُعتمدة: | P20 RR021945 United States RR NCRR NIH HHS; P30 DK072476 United States DK NIDDK NIH HHS; R01 AG030226 United States AG NIA NIH HHS; U24 DK097209 United States DK NIDDK NIH HHS; R37 AG028730 United States AG NIA NIH HHS; DP1 AG058605 United States AG NIA NIH HHS; P20 GM103528 United States GM NIGMS NIH HHS; R01 DK100263 United States DK NIDDK NIH HHS; R01 AG019719 United States AG NIA NIH HHS; P30 GM118430 United States GM NIGMS NIH HHS |
| فهرسة مساهمة: | Keywords: Exercise; High fat feeding; Insulin sensitivity; Mitochondrial gene expression; Nicotinamide adenine dinucleotide; Nicotinamide phosphoribosyl transferase |
| المشرفين على المادة: | 0 (Cytokines) 0U46U6E8UK (NAD) EC 2.4.2.12 (Nicotinamide Phosphoribosyltransferase) EC 2.4.2.12 (nicotinamide phosphoribosyltransferase, mouse) |
| تواريخ الأحداث: | Date Created: 20171118 Date Completed: 20190520 Latest Revision: 20190520 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC5784330 |
| DOI: | 10.1016/j.molmet.2017.10.012 |
| PMID: | 29146412 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 2212-8778 |
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| DOI: | 10.1016/j.molmet.2017.10.012 |