دورية أكاديمية
أعرض في EDS

Functional connectivity of the vigilant-attention network in children and adolescents with attention-deficit/hyperactivity disorder.

التفاصيل البيبلوغرافية
العنوان: Functional connectivity of the vigilant-attention network in children and adolescents with attention-deficit/hyperactivity disorder.
المؤلفون: Zepf FD; Centre & Discipline of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, School of Medicine, Division of Psychiatry and Clinical Neurosciences & Division of Pediatrics and Child Health, The University of Western Australia, Perth, Australia; Specialised Child and Adolescent Mental Health Services (CAMHS), Department of Health in Western Australia, Perth, Australia; Clinic for Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, RWTH Aachen University, Aachen, Germany. Electronic address: florian.zepf@uwa.edu.au., Bubenzer-Busch S; Clinic for Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, RWTH Aachen University, Aachen, Germany., Runions KC; Community Child and Adolescent Mental Health Services (CAMHS), Department of Health in Western Australia, Perth, Australia; Telethon Kids Institute, Perth, Australia., Rao P; Centre & Discipline of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, School of Medicine, Division of Psychiatry and Clinical Neurosciences & Division of Pediatrics and Child Health, The University of Western Australia, Perth, Australia; Community Child and Adolescent Mental Health Services (CAMHS), Department of Health in Western Australia, Perth, Australia., Wong JWY; Centre & Discipline of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, School of Medicine, Division of Psychiatry and Clinical Neurosciences & Division of Pediatrics and Child Health, The University of Western Australia, Perth, Australia; Specialised Child and Adolescent Mental Health Services (CAMHS), Department of Health in Western Australia, Perth, Australia; Telethon Kids Institute, Perth, Australia., Mahfouda S; Centre & Discipline of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, School of Medicine, Division of Psychiatry and Clinical Neurosciences & Division of Pediatrics and Child Health, The University of Western Australia, Perth, Australia; Telethon Kids Institute, Perth, Australia., Morandini HAE; Centre & Discipline of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, School of Medicine, Division of Psychiatry and Clinical Neurosciences & Division of Pediatrics and Child Health, The University of Western Australia, Perth, Australia., Stewart RM; Centre & Discipline of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, School of Medicine, Division of Psychiatry and Clinical Neurosciences & Division of Pediatrics and Child Health, The University of Western Australia, Perth, Australia., Moore JK; Centre & Discipline of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, School of Medicine, Division of Psychiatry and Clinical Neurosciences & Division of Pediatrics and Child Health, The University of Western Australia, Perth, Australia; Paediatric Consultation-Liaison Program, Child and Adolescent Mental Health Services, Department of Health in Western Australia, Perth, Australia., Biskup CS; Clinic for Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, RWTH Aachen University, Aachen, Germany., Eickhoff SB; Institute of Neuroscience and Medicine (INM-1, INM-7), Research Centre Jülich, Jülich, Germany; Institute of Clinical Neuroscience & Medical Psychology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany; Institute of Systems Neuroscience, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Fink GR; Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research Centre Jülich, Jülich, Germany; Department of Neurology, University of Cologne, Cologne, Germany., Langner R; Institute of Neuroscience and Medicine (INM-1, INM-7), Research Centre Jülich, Jülich, Germany; Institute of Clinical Neuroscience & Medical Psychology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany; Institute of Systems Neuroscience, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany. Electronic address: robert.langner@uni-duesseldorf.de.
المصدر: Brain and cognition [Brain Cogn] 2019 Apr; Vol. 131, pp. 56-65. Date of Electronic Publication: 2017 Nov 14.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 8218014 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2147 (Electronic) Linking ISSN: 02782626 NLM ISO Abbreviation: Brain Cogn
أسماء مطبوعة: Original Publication: New York : Academic Press, [c1982-
مواضيع طبية MeSH: Attention/*physiology , Attention Deficit Disorder with Hyperactivity/*diagnostic imaging , Brain/*diagnostic imaging , Nerve Net/*diagnostic imaging, Adolescent ; Attention Deficit Disorder with Hyperactivity/physiopathology ; Brain/physiopathology ; Brain Mapping ; Child ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Nerve Net/physiopathology
مستخلص: The ability to maintain attention to simple tasks (i.e., vigilant attention, VA) is often impaired in attention-deficit/hyperactivity disorder (ADHD), but the underlying pathophysiological mechanisms at the brain network level are not clear yet. We therefore investigated ADHD-related differences in resting-state functional connectivity within a meta-analytically defined brain network of 14 distinct regions subserving VA (comprising 91 connections in total), as well as the association of connectivity with markers of behavioural dysfunction in 17 children (age range: 9-14 years) with a diagnosis of ADHD and 21 age-matched neurotypical controls. Our analyses revealed selective, rather than global, differences in the intrinsic coupling between nodes of the VA-related brain network in children with ADHD, relative to controls. In particular, ADHD patients showed substantially diminished intrinsic coupling for 7 connections and increased coupling for 4 connections, with many differences involving connectivity with the anterior insula. Moreover, connectivity strength of several aberrant connections was found to be associated with core aspects of ADHD symptomatology, such as poor attention, difficulties with social functioning, and impaired cognitive control, attesting to the behavioural relevance of specific connectivity differences observed in the resting state.
(Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.)
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معلومات مُعتمدة: R01 MH074457 United States MH NIMH NIH HHS
فهرسة مساهمة: Keywords: ADHD; Adolescents; Alertness; Children; Resting-state fMRI; Sustained attention
تواريخ الأحداث: Date Created: 20171119 Date Completed: 20190726 Latest Revision: 20210227
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC6432906
DOI: 10.1016/j.bandc.2017.10.005
PMID: 29150311
قاعدة البيانات: MEDLINE
الوصف
تدمد:1090-2147
DOI:10.1016/j.bandc.2017.10.005